Vitamin-E diffused highly cross-linked polyethylene liner compared to standard liners in total hip arthroplasty. A randomized, controlled trial

Salemyr, Mats; Muren, Olle; Ahl, Torbjörn; Bodén, Henrik; Chammout, Ghazi; Stark, André; Sköldenberg, Olof

doi:10.1007/s00264-015-2680-3

Cited by 55 publications

(67 citation statements)

References 15 publications

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“…Only a RCT has been conducted [ 51 ] to compare the wear properties of VE-diffused UHMWPE liner (E1™, Biomet, Table 1 ) with those of highly cross-linked UHMWPE liner (Marathon™, Depuy) articulating with the same 32 mm cobalt-chrome head. Femoral head penetration in the medial/lateral and vertical directions was significantly lower for VE-diffused UHMWPE liners up to two-year follow-up.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review

Gigante

Bottegoni

Ragone³

et al. 2015

JFB

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Since polyethylene is one of the most frequently used biomaterials, such as in bearing components in joint arthroplasty, strong efforts have been made to improve the design and material properties over the last decades. Antioxidants, such as vitamin-E, seem to be a promising alternative to further increase durability and reduce polyethylene wear and degradation in the long-term. Nevertheless, even if several promising in vitro results are available, there is yet no clinical evidence that vitamin-E polyethylenes show these advantages in vivo. The aim of this paper was to provide a comprehensive overview on the current knowledge regarding the biological and mechanical proprieties of this biomaterial, underlying the in vitro and in vivo evidence for effectiveness of vitamin-E-doped polyethylene in joint arthroplasty.

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Section: Resultsmentioning

confidence: 99%

Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review

Gigante

Bottegoni

Ragone³

et al. 2015

JFB

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“…Prospective studies at two to three years follow-up demonstrated no significant differences in femoral head penetration rates between vitamin E doped and virgin highly crosslinked liners [ 150 , 151 , 152 ].…”

Section: 2nd Generation Highly Crosslinked Polyethylenementioning

confidence: 99%

Ultra-High Molecular Weight Polyethylene: Influence of the Chemical, Physical and Mechanical Properties on the Wear Behavior. A Review

et al. 2017

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Ultra-high molecular weight polyethylene (UHMWPE) is the most common bearing material in total joint arthroplasty due to its unique combination of superior mechanical properties and wear resistance over other polymers. A great deal of research in recent decades has focused on further improving its performances, in order to provide durable implants in young and active patients. From “historical”, gamma-air sterilized polyethylenes, to the so-called first and second generation of highly crosslinked materials, a variety of different formulations have progressively appeared in the market. This paper reviews the structure–properties relationship of these materials, with a particular emphasis on the in vitro and in vivo wear performances, through an analysis of the existing literature.

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“…Hence, the clinical need to increase the lifespan of THA to 20 to 30 years have led to the development of additional “second‐generation HXLPE” so as to reduce wearing using a method other than irradiation . To reduce the production of wear particles and improve wear resistance, it is important to understand the tribology of the natural synovial joints and the role of lubrication.…”

mentioning

confidence: 99%

Clinical safety and wear resistance of the phospholipid polymer-grafted highly cross-linked polyethylene liner

et al. 2016

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To reduce the production of wear particles and subsequent aseptic loosening, we created a human articular cartilage-mimicked surface for a highly cross-linked polyethylene liner, whose surface grafted layer consisted of a biocompatible phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine). Although our previous in vitro findings showed that poly(2-methacryloyloxyethyl phosphorylcholine)-grafted particles were biologically inert and caused no subsequent bone resorptive responses, and poly(2-methacryloyloxyethyl phosphorylcholine) grafting markedly decreased wear in hip joint simulator tests, the clinical safety, and in vivo wear resistance of poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners remained open to question. Therefore, in the present study, we evaluated clinical and radiographic outcomes of poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners 5 years subsequent to total hip replacement in 68 consecutive patients. No reoperation was required for any reason, and no adverse events were associated with the implanted liners. The average Harris Hip Score increased from 38.6 preoperatively to 96.5 5 years postoperatively, and health-related quality of life, as indicated by the Short Form 36 Health Survey, improved. Radiographic analyses showed no periprosthetic osteolysis or implant migration. Between 1 and 5 years postoperatively, the mean steady-state wear rate was 0.002 mm/year, which represented a marked reduction relative to other highly cross-linked polyethylene liners, and appeared to be unaffected by patient-related or surgical factors. Although longer follow up is required, poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners improved mid-term clinical outcomes. The clinical safety and wear-resistance results are encouraging with respect to the improvement of long-term clinical outcomes with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2007-2016, 2017.

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Vitamin-E diffused highly cross-linked polyethylene liner compared to standard liners in total hip arthroplasty. A randomized, controlled trial

Cited by 55 publications

References 15 publications

Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review

Effectiveness of Vitamin-E-Doped Polyethylene in Joint Replacement: A Literature Review

Ultra-High Molecular Weight Polyethylene: Influence of the Chemical, Physical and Mechanical Properties on the Wear Behavior. A Review

Clinical safety and wear resistance of the phospholipid polymer-grafted highly cross-linked polyethylene liner

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