Vitamin E As an Antioxidant Reduces Apoptosis of Cells in Rat Hippocampus Following Exposure to Polyvinyl Chloride

Sadeghi, Abbas; Ghahari, Laya

doi:10.5812/amh.85275

Cited by 2 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, it inhibits DNA damage and neural apoptosis [ 83 ]. In addition, it diminishes the apoptosis of cells in the rat hippocampus after polyvinyl chloride exposure [ 84 ]. Vitamin C is also useful in modulating oxidative stress, autophagy, and apoptosis in bone marrow stromal cells [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways

Abu-Elfotuh,

Tolba,

Hussein

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a devastating illness with limited therapeutic interventions. The aim of this study is to investigate the pathophysiological mechanisms underlying AD and explore the potential neuroprotective effects of cocoa, either alone or in combination with other nutraceuticals, in an animal model of aluminum-induced AD. Rats were divided into nine groups: control, aluminum chloride (AlCl3) alone, AlCl3 with cocoa alone, AlCl3 with vinpocetine (VIN), AlCl3 with epigallocatechin-3-gallate (EGCG), AlCl3 with coenzyme Q10 (CoQ10), AlCl3 with wheatgrass (WG), AlCl3 with vitamin (Vit) B complex, and AlCl3 with a combination of Vit C, Vit E, and selenium (Se). The animals were treated for five weeks, and we assessed behavioral, histopathological, and biochemical changes, focusing on oxidative stress, inflammation, Wnt/GSK-3β/β-catenin signaling, ER stress, autophagy, and apoptosis. AlCl3 administration induced oxidative stress, as evidenced by elevated levels of malondialdehyde (MDA) and downregulation of cellular antioxidants (Nrf2, HO-1, SOD, and TAC). AlCl3 also upregulated inflammatory biomarkers (TNF-α and IL-1β) and GSK-3β, leading to increased tau phosphorylation, decreased brain-derived neurotrophic factor (BDNF) expression, and downregulation of the Wnt/β-catenin pathway. Furthermore, AlCl3 intensified C/EBP, p-PERK, GRP-78, and CHOP, indicating sustained ER stress, and decreased Beclin-1 and anti-apoptotic B-cell lymphoma 2 (Bcl-2) expressions. These alterations contributed to the observed behavioral and histological changes in the AlCl3-induced AD model. Administration of cocoa, either alone or in combination with other nutraceuticals, particularly VIN or EGCG, demonstrated remarkable amelioration of all assessed parameters. The combination of cocoa with nutraceuticals attenuated the AD-mediated deterioration by modulating interrelated pathophysiological pathways, including inflammation, antioxidant responses, GSK-3β-Wnt/β-catenin signaling, ER stress, and apoptosis. These findings provide insights into the intricate pathogenesis of AD and highlight the neuroprotective effects of nutraceuticals through multiple signaling pathways.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways

Abu-Elfotuh,

Tolba,

Hussein

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…We orally administered vitamin E (150 mg/kg.bw/day) and PVC (1000 mg/kg.bw/day) for 40 days. The PVC (Merck, Germany) and vitamin E were used as described in previous studies (11,12).…”

Section: Methodsmentioning

confidence: 99%

“…Research results have shown that PVC contributes to some neurodegenerative diseases. Vitamin E is one of the most important antioxidants that can prevent damaging effects leading to a number of diseases, such as diabetes (11)(12)(13), stroke (14,15), Alzheimer (16,17), and aging (18).…”

Section: Introductionmentioning

confidence: 99%

Vitamin E Supplementation Reduces Oxidative Stress in the Male Wistar Rats’ Brain Against Polyvinyl Chloride Products

Sadeghi

Ghahari

Yousefpour

2019

Ann Mil Health Sci Res

Self Cite

View full text Add to dashboard Cite

Background: Polyvinyl chloride (PVC) exerts toxic effects via the formation of oxidative stress on the brain. Antioxidants such as Vitamin E (Vit E) can affect free radicals. Objectives: This study was conducted to decrease damage and oxidative stress against PVC products in rats' brain by vitamin E. Methods: In the current study, we used 24 male Wistar rats in four groups (N = 6 rats per group) as the control, Vit E, PVC, PVC plus Vit E. We orally administered vitamin E and PVC for 40 days. Then the rats were anesthetized and the brain was removed and transferred to a temperature of-70ºC in order to measure lipid peroxidation. Results: our results revealed that oral administration of PVC decreased catalase and total antioxidant capacity levels, and increased malondialdehyde in PVC exposed rats. Vitamin E improved spatial memories by enhancing neurogenesis in the brain. Conclusions: Exposure to PVC can produce oxidative stress enzymes and make brain damage. Vitamin E, as an antioxidant, can decrease the toxic effects of PVC and protect the brain.

show abstract

Vitamin E As an Antioxidant Reduces Apoptosis of Cells in Rat Hippocampus Following Exposure to Polyvinyl Chloride

Cited by 2 publications

References 25 publications

Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways

Anti-Alzheimer Activity of Combinations of Cocoa with Vinpocetine or Other Nutraceuticals in Rat Model: Modulation of Wnt3/β-Catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 Pathways

Vitamin E Supplementation Reduces Oxidative Stress in the Male Wistar Rats’ Brain Against Polyvinyl Chloride Products

Contact Info

Product

Resources

About