Vitamin E as an Antioxidant in Female Reproductive Health

Mutalip, Siti Syairah Mohd; Ab‐Rahim, Sharaniza; Rajikin, Mohd Hamim

doi:10.3390/antiox7020022

Cited by 70 publications

(46 citation statements)

References 133 publications

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“…Another part of this special issue presents specific effects of vitamin E. Mutalip et al [ 9 ] answers the question: What are the known roles of vitamin E as an antioxidant in female reproductive health? This paper comes back to the initial discovery of vitamin E in 1922 as a substance necessary for reproduction.…”

mentioning

confidence: 99%

Vitamin E

Böhm

2018

Antioxidants

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mentioning

confidence: 99%

Vitamin E

Böhm

2018

Antioxidants

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“…Vitamin E is necessary for reproduction (Mohd Mutalip et al, 2018). Only a few studies have investigated the relationship among vitamin E, its analogs, and COXs (Sakamoto et al, 1991;Beharka et al, 1997;Wu et al, 1998Wu et al, , 2005Lee et al, 2006;Kim et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

α-Tocopherol Potentiates the Cervical Resistance Decreasing Effects of COX Inhibitors in Pregnant Rats: The Putative Role of Cyclooxygenase-2 Inhibition

Kothencz

Hajagos-Tóth

Szűcs

et al. 2018

J Pharmacol Exp Ther

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Vitamin E and their analogs as antioxidant and lipid-soluble compounds can have diverse effects on the physiologic processes. By binding to receptors and enzymes, they may modify the action of drugs. It has been proved that a-tocopherol succinate modifies the effects of b 2 agonist terbutaline and cyclooxygenase (COX) inhibitors on rat trachea and myometrium. Our aim was to investigate how a-tocopherol and COX inhibitors may influence cervical resistance in rats. The cervical resistance of nonpregnant and 22 day-pregnant Sprague-Dawley rats was determined in an isolated organ bath in vitro. a-Tocopherol-succinate (10 2 7 M) was used, whereas the COX-nonselective diclofenac (10 2 6 M), the COX-2-selective rofecoxib (10 26 M), and the COX-1-selective SC-560 (10 26 M) were applied as inhibitors. The COX activities of the cervices were measured by enzyme immunoassay. The modifying effect of single doses of COX inhibitors and tocopherol on the onset of labor was investigated in vivo. The cervical resistance of nonpregnant samples was not changed by either a-tocopherol or COX inhibitors. On pregnant cervices, tocopherol, diclofenac, or rofecoxib pretreatment decreased cervical resistance that was further reduced by COX inhibitors after pretreatment with tocopherol. a-Tocopherol elicited a significant COX-2 enzyme inhibition in cervical samples from pregnant rats. By coadministration of tocopherol and rofecoxib, the parturition was initiated earlier than in the other groups. It is supposed that COXs play a significant role not only in cervical ripening, but also in the contraction of the cervical smooth muscle a few hours before parturition. This latter action may be developed by COX-2-liberated prostaglandins.

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“…Corn bran contains a high concentration of tocochromanols [48] which refers to tocopherol and tocotrienol homologues in a collective sense [49]. It must be emphasized that tocopherol and tocotrienol are antioxidant vitamins [50] and thus are ideal candidate in impairing free radical propagation reactions that leads to oxidative stress. The bran of corn contains higher concentrations of insoluble dietary fibre composed primarily of cellulose, which consists of approximately 280 g/kg, and hemicellulose constituting approximately 700 g/kg [51].…”

Section: Bioactive Properties Of Plant-based Food By-products From Inmentioning

confidence: 99%

Plant-Based Food By-Products: Prospects for Valorisation in Functional Bread Development

Amoah

Taarji

Johnson³

et al. 2020

Sustainability

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The industrial and small-scale processing of plant-based food materials is associated with by-products that may have a negative impact on the environment but could add value to bread-based products. The bioactivity of plant-based food by-products, their impact on the properties of functional bread, and their bioavailability/bioaccessibility leading to potential health effects when consumed was reviewed. Plant-based food by-products which may be added to bread include rice bran, wheat bran, corn bran, grape pomace/seed extract, tomato seed/skin, and artichoke stems/leaves. These by-products contain high concentrations of bioactive compounds, including phenolics, bioactive peptides, and arabinoxylan. Pre-treatment procedures, including fermentation and thermal processing, impact the properties of plant-based by-products. In most cases, bread formulated with flour from plant-based by-products demonstrated increased fibre and bioactive compound contents. In terms of the sensory and nutritional acceptability of bread, formulations with an average of 5% flour from plant-based by-products produced bread with acceptable sensory properties. Bread enriched with plant-based by-products demonstrated enhanced bioavailability and bioaccessibility and favourable bioactive properties in human blood, although long-term studies are warranted. There is a need to investigate the bioactive properties of other underutilised plant-based by-products and their potential application in bread as a sustainable approach towards improving food and nutrition security.

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Vitamin E as an Antioxidant in Female Reproductive Health

Cited by 70 publications

References 133 publications

Vitamin E

Vitamin E

α-Tocopherol Potentiates the Cervical Resistance Decreasing Effects of COX Inhibitors in Pregnant Rats: The Putative Role of Cyclooxygenase-2 Inhibition

Plant-Based Food By-Products: Prospects for Valorisation in Functional Bread Development

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