Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial

Golmakani, Nahid; Emamverdikhan, Aazam Parnan; Zarifian, Ahmadreza; Tabassi, Sayyed Abolghasem Sajadi; Hassanzadeh, Malihe

doi:10.1007/s00192-018-3698-z

Cited by 16 publications

(25 citation statements)

References 27 publications

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“…The protective effect of vitamins E on sleep quality has been recently shown [131]. It could also be an alternative to vaginal estrogen in relieving the symptoms of vaginal atrophy in postmenopausal women [132,133,134]. In postmenopausal women with vitamin D deficiency, isolated supplementation of vitamin D3 were associated with a reduction in the metabolic syndrome risk profile, but also with a lower risk of hypertriglyceridemia and hyperglycemia [135,136,137].…”

Section: Vitaminsmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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The menopausal transition, or perimenopause, is characterized by menstrual irregularities, vasomotor symptoms, sleep disturbances, mood symptoms, and urogenital tract atrophy. These changes can also affect the quality of life and one’s self-esteem. Hormone replacement therapy (HRT) is considered the best option to achieve therapeutic relief of different menopausal symptoms but is usually restricted to moderate or severe symptoms. Moreover, many women refuse HRT for a variety of reasons concerning the fear of cancer and other adverse effects. According to these considerations, new topics are emerging: Dissatisfaction with drug costs and conventional healthcare, desire for personalized medicines, and the public perception that “natural is good”. In this context, nonhormonal therapies are mostly evolving, and it is not unusual that women often request a “natural” approach for their symptoms. The aim of this study is to investigate nonhormonal therapies that have been identified to reduce the menopausal symptoms.

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Section: Vitaminsmentioning

confidence: 99%

A Nutraceutical Approach to Menopausal Complaints

et al. 2019

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“…All subjects in the included studies were accounted for. In the Ziagham et al’s studies [ 23 27 ], double-blinding was used, while Golmakani et al [ 28 ] described single-blinding (of investigators), and Parnan Emamverdikhan et al [ 29 ] did not comment on whether investigators were blinded to the subjects’ allocation group.…”

Section: Resultsmentioning

confidence: 99%

“…The four RCTs included in the review were all conducted in Iran through university-based health centers between 2010 and 2014 (see study characteristics, Table 2 ). Two eight-week trials reported by Ziagham et al [ 23 27 ] recruited women from 2010 to 2011, and two 12 weeks trials were reported by Parnan Emamverdikhan et al [ 29 ] and Golmakani et al [ 28 ], recruiting from 2013 to 2014. In all studies, the intervention was vaginal vitamin E suppositories in healthy postmenopausal women with genitourinary symptoms.…”

Section: Resultsmentioning

confidence: 99%

Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials

et al. 2022

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Genitourinary syndrome of menopause significantly affects the quality of life in postmenopausal women with few evidence-based alternatives to vaginal estrogen for women with contraindications. This systematic review evaluates the evidence for vaginal vitamin E efficacy in reducing patient-reported genitourinary symptoms in healthy postmenopausal women compared to placebo or vaginal control therapy. This systematic review evaluated randomized controlled trials before October 2020 that assessed the efficacy of vitamin E vaginal suppositories in reducing genitourinary symptoms in postmenopausal women compared with a control group of healthy postmenopausal women. Outcomes included patient-perceived genitourinary symptoms. Of the 31 studies, four met the inclusion criteria. One 8-week trial (n = 42) found a significant reduction in vaginal symptoms in the 1 mg vitamin E group than the placebo group (difference in means, 5.3; 95% confidence interval [CI], 4.4 to 6.2). Another 8-week trial (n = 40) found 5 mg vaginal hyaluronic acid superior to 1 mg vitamin E (difference in means -0.50, 95% CI, -0.95 to -0.05). Two 12-week trials (n = 52 in each) found no difference between 0.5 g vaginal estrogen and 100 IU vaginal vitamin E in healthy postmenopausal women (difference in means: -0.19, 95% CI, -4.4 to 4.0, and -3.47, 95% CI, -13.8 to 6.8). Evidence from small, limited studies suggests that vaginal vitamin E may be effective in alleviating symptoms of genitourinary syndrome of menopause; however, additional high-quality studies are needed to determine efficacy, ideal dosing, and long-term safety.

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“…De igual manera, se observó que es inusual la presencia de una sola disfunción sexual (7,73 %). La prevalencia de SGUM en esta investigación es concordante con la descrita por otros autores (10,12,15), pero inferior a lo reportado por Moral et al, que informan una prevalencia del 70 % (16).…”

Section: Discussionunclassified

Prevalencia del síndrome genitourinario de la menopausia en mujeres e impacto en la sexualidad, en Quindío (Colombia), 2013-2016

Hoz¹

2018

Rev. Colomb. Obstet. Ginecol.

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Objetivo: conocer la prevalencia del síndrome genitourinario de la menopausia en una población de mujeres sexualmente activas, con edad igual o mayor a 40 años.Materiales y métodos: estudio de corte transversal descriptivo. Se incluyeron mujeres diagnosticadas con menopausia, con actividad sexual en las últimas seis semanas, y residentes en el Quindío, departamento ubicado en la zona andina cafetera en Colombia. Se excluyeron mujeres con menopausia quirúrgica, analfabetas, con padecimientos de trastornos mentales o déficit mental. El estudio se realizó en una institución privada de referencia entre el 2013 y 2016. Se hizo un muestreo consecutivo por conveniencia. Se midieron variables sociodemográficas, síntomas vulvo-vaginales y síntomas del tracto urinario inferior relacionados con la presencia del síndrome genitourinario de la menopausia, presencia de disfunción sexual global por medio del Índice de Función Sexual Femenina validado en español, y por tipo de disfunción. Se realizó un análisis descriptivo de la información utilizando medidas de frecuencia absoluta y relativa. Se calculó la prevalencia como: número de mujeres con síndrome genitourinario de la menopausia / número de mujeres encuestadas.Resultados: de un total de 597 mujeres seleccionadas para participar, se analizaron finalmente 558 (93,46 %). La edad promedio fue de 59,73 ± 8,4 años. La prevalencia del síndrome genitourinario de la menopausia fue del 51,61 % (62,88 % en las mayores de 55 años y 39,32 % en las menores de 55 años). La prevalencia de disfunción sexual en el grupo estudiado fue del 67,2 %. Se presentaron trastornos en el deseo (67,2 %), la excitación (45,16 %), el orgasmo (44,08 %), la lubricación (32,25 %) y dolor durante la relación (13,97 %).Conclusión: en el grupo de población evaluado se encontró una importante prevalencia del síndrome genitourinario de la menopausia y de disfunción sexual. Se requieren estudios poblacionales para hacer una aproximación a la magnitud del fenómeno en la región latinoamericana.

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Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial

Cited by 16 publications

References 27 publications

A Nutraceutical Approach to Menopausal Complaints

A Nutraceutical Approach to Menopausal Complaints

Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials

Prevalencia del síndrome genitourinario de la menopausia en mujeres e impacto en la sexualidad, en Quindío (Colombia), 2013-2016

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