Vitamin E and Rabbit Corneal Endothelial Cell Survival

Abstract

Abstract

Antioxidants reduce TGF‐beta2‐induced gene expressions in human optic nerve head astrocytes

“…Until now, vitamin E has already been shown to exert protective effects in various ocular tissues. For instance, it improves corneal endothelial cell (Neuwirth‐Lux & Billson 1987) and retinal cell survival (Rego et al. 1998) and protects the retina from photooxidative injuries (Aonuma et al.…”

Phacoemulsification-induced injury in corneal endothelial cells mediated by apoptosis: In vitro model

“…In addition, it has been found that free-radical scavengers, such as ascorbic acid and glutathione, significantly reduce the effects of free radicals. [15][16][17][19][20][21][22] The deleterious effect of free radicals on CECs and the protective properties of antioxidants in this connection have been established, 20,23 and the current use of the new solutions (ie, fortified balanced salt solution [BSS Plus]) that contains scavengers reduces CEC loss. However, how this cell death occurs is not well understood.…”

“…Phacoemulsification increases the temperature of the media and causes heat damage to the cells. The chemical damage is mediated by free radicals formed in the aqueous humor 9-19 through the imploding of cavitation bubbles 11 that are generated during the procedure.Several studies [15][16][17][19][20][21][22] indicate that various freeradical scavengers have a protective effect on the cornea, suggesting their potential for preventing phacoemulsification-induced CEC loss. Holst et al 9 found that phacoemulsification, both in vitro and in vivo, was associated with the presence of free radicals and ultraviolet radiation, which could be reduced by adding superoxide dismutase to the irrigation solution; however, the authors did not evaluate whether the reduction could effectively reduce CEC loss.…”