Mucoadhesive phenylboronic acid conjugated chitosan oligosaccharide-vitamin E copolymer for topical ocular delivery of voriconazole: Synthesis, in vitro/vivo evaluation, and mechanism

Sun, Xingchen; Sheng, Yuhui; Li, Keke; Sai, Sixiang; Feng, Jie; Zhang, Jiasong; Han, Jingtian; Tian, Baocheng

doi:10.1016/j.actbio.2021.10.047

Cited by 40 publications

(20 citation statements)

References 48 publications

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“…Due to improved mucoadhesion, nanomicelles were retained in contact with the ocular mucosa for a long time and prolonged release of voriconazole was ensured. 89…”

Section: Chemical Modifications Of Polymersmentioning

confidence: 99%

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Recent advances in functionally modified polymers for mucoadhesive drug delivery

2022

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“…Due to improved mucoadhesion, nanomicelles were retained in contact with the ocular mucosa for a long time and prolonged release of voriconazole was ensured. 89…”

Section: Chemical Modifications Of Polymersmentioning

confidence: 99%

“…Due to improved mucoadhesion, nanomicelles were retained in contact with the ocular mucosa for a long time and prolonged release of voriconazole was ensured. 89 Fig. 6 Various thiolation techniques for polymers containing amino, hydroxy and carboxylic acid groups.…”

Section: Thiolation Techniques To Improve Mucoadhesionmentioning

confidence: 99%

Recent advances in functionally modified polymers for mucoadhesive drug delivery

2022

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“…C6 delivery through a monolayer of HCE-T cells and 3D cell spheroids demonstrated strong corneal penetration ability. Several characteristics of the polymer were able to influence nanomicelle uptake, but the key role in the process of cellular endocytosis was attributed to the high-affinity interaction between the PBA portion and sialic acid on the surface of the cell membrane [ 125 ]. Another study using C6 as a fluorescent probe was reported by Sai et al, aiming to evaluate the corneal transportation of an in-situ gelling system based on mixed micelles.…”

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

“…Moreover, rapid clearance remains a challenge for nanosystems as they need to release their payload before being eliminated from the eye. Many studies focus on assessing the distribution in various tissues once the formulation has been instilled into the eye [ 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 134 , 137 , 138 , 139 ]. Unfortunately, few studies focus on assessing how mechanisms including blinking, tear drainage and ocular metabolism may interact with nanosystems [ 66 , 115 ].…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

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The greatest challenge associated with topical drug delivery for the treatment of diseases affecting the posterior segment of the eye is to overcome the poor bioavailability of the carried molecules. Nanomedicine offers the possibility to overcome obstacles related to physiological mechanisms and ocular barriers by exploiting different ocular routes. Functionalization of nanosystems by fluorescent probes could be a useful strategy to understand the pathway taken by nanocarriers into the ocular globe and to improve the desired targeting accuracy. The application of fluorescence to decorate nanocarrier surfaces or the encapsulation of fluorophore molecules makes the nanosystems a light probe useful in the landscape of diagnostics and theranostics. In this review, a state of the art on ocular routes of administration is reported, with a focus on pathways undertaken after topical application. Numerous studies are reported in the first section, confirming that the use of fluorescent within nanoparticles is already spread for tracking and biodistribution studies. The first section presents fluorescent molecules used for tracking nanosystems’ cellular internalization and permeation of ocular tissues; discussions on the classification of nanosystems according to their nature (lipid-based, polymer-based, metallic-based and protein-based) follows. The following sections are dedicated to diagnostic and theranostic uses, respectively, which represent an innovation in the ocular field obtained by combining dual goals in a single administration system. For its great potential, this application of fluorescent nanoparticles would experience a great development in the near future. Finally, a brief overview is dedicated to the use of fluorescent markers in clinical trials and the market in the ocular field.

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“…Nowadays, bioadhesive formulations are increasingly becoming a very important class of dosage in the forms of films [1][2][3], tablets [4], nanoparticles [5,6], etc. Buccal mucoadhesive films are one of the most innovative and promising groups of dosage forms.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid

et al. 2022

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Nowadays, the buccal administration of mucoadhesive films is very promising. Our aim was to prepare ascorbic acid-containing chitosan films to study the properties and structures important for applicability and optimize the composition. During the formulation of mucoadhesive films, chitosan as the polymer basis of the film was used. Ascorbic acid, which provided the acidic pH, was used in different concentrations (2–5%). The films were formulated by the solvent casting method. The properties of films important for applicability were investigated, such as physical parameters, mucoadhesive force, surface free energy, and breaking strength. The fine structure of the films was analyzed by atomic force microscopy, and the free volume was analyzed by PALS, which can be important for drug release kinetics and the location of the drug in the film. The applicability of the optimized composition was also tested with two different types of active ingredients. The structure of the films was also analyzed by XRPD and FTIR. Ascorbic acid can be used well in chitosan films, where it can function as a permeation enhancer when reacting to chitosan, it is biodegradable, and can be applied in 2% of our studies.

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Mucoadhesive phenylboronic acid conjugated chitosan oligosaccharide-vitamin E copolymer for topical ocular delivery of voriconazole: Synthesis, in vitro/vivo evaluation, and mechanism

Cited by 40 publications

References 48 publications

Recent advances in functionally modified polymers for mucoadhesive drug delivery

Recent advances in functionally modified polymers for mucoadhesive drug delivery

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

Investigation of Surface Properties and Free Volumes of Chitosan-Based Buccal Mucoadhesive Drug Delivery Films Containing Ascorbic Acid

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