Vitamin D3 stimulates the production of prostacyclin by vascular smooth muscle cells

Wakasugi, Masakiyo; Noguchi, Takehiko; Inoue, Masaharu; Kazama, Y.; Tawata, Masato; Kanemaru, Yoshifumi; Onaya, Toshimasa

doi:10.1016/0090-6980(91)90072-n

Cited by 71 publications

(39 citation statements)

References 34 publications

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“…Association between low or deficient 25-hydroxyvitamin D and impaired brachial artery FMD was demonstrated in a general population of middle-aged and older adults and in ESRD patients (22,24). It was shown experimentally that exposure to cholecalciferol improved the relaxation response of spontaneously hypertensive rat arteries to acetylcholine (25) and that vitamin D 3 stimulated prostacyclin production by vascular smooth muscle cells (26). Moreover, studies on aortic rings of spontaneously hypertensive rats have shown that Vitamin D derivatives acutely reduce endothelium-dependent contraction by reducing calcium influx into endothelial cells and decreasing production of endothelium-derived contracting factors (27).…”

Section: Discussionmentioning

confidence: 99%

Flow-Mediated Vasodilation in End-Stage Renal Disease

Verbeke

Pannier²,

Guérin³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives An intact endothelium is essential for adaptations between arterial vasomotor tone and shear stress (SS), i.e., flow-mediated vasodilation (FMD). Endothelial dysfunction occurs in hypertension, cardiac insufficiency, diabetes, atherosclerosis, and in end-stage renal disease (ESRD) patients, whose renal failure is associated with many of those cardiovascular diseases (CVD).Design, setting, participants, & measurements Using a progressive hand-warming protocol and repeated measures ANOVA, we analyzed SS-mediated increase of brachial artery diameter (⌬BA) in 22 healthy controls, 18 CVD-negative ESRD patients (ESRD-CVD Ϫ ), and 17 CVD-positive ESRD patients (ESRD-CVD ϩ ) to analyze the role of uremia versus CVD on FMD.Results Hand-warming increased SS (P Ͻ 0.001) and ⌬BA (P Ͻ 0.001). Negative interactions were observed between ⌬BA and ESRD (P Ͻ 0.001), and between ⌬BA and CVD ؉ (P Ͻ 0.02), but there was no interaction between ESRD and CVD ϩ (P ϭ 0.69). For low and mild SS increases, ESRD-CVD Ϫ patients were characterized by similar ⌬BA as controls, but it was lower than controls at higher SS (P Ͻ 0.01). In ESRD-CVD ϩ patients, brachial artery diameter did not respond to mild and moderate SS increases, and showed "paradoxical" vasoconstriction at higher SS (P Ͻ 0.05). In ESRD, a positive and independent interaction was observed between ⌬BA and 25(OH) vitamin D 3 insufficiency (Յ15 g/L; P Ͻ 0.02). ConclusionsThese observations indicate that, independently of each other, ESRD and CVD ϩ history are associated with endothelial dysfunction. They also suggest the importance of considering the relationships between SS and endothelial function in different clinical conditions.

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Section: Discussionmentioning

confidence: 99%

Flow-Mediated Vasodilation in End-Stage Renal Disease

Verbeke

Pannier²,

Guérin³

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…39 Other antihypertensive effects of vitamin D include renoprotective effects, vasodilatatory and antiatherosclerotic properties, and effects on calcium homeostasis including prevention of secondary hyperparathyroidism. 18,40,41 In contrast, PTH has been shown to stimulate renin release by activation of the renin-angiotensinaldosterone system. 18 Additionally, PTH may affect blood pressure by its direct effects on arteries and By analysis of covariance with serum 25OHD and PTH concentration included simultaneously in all crude and adjusted models.…”

Section: -O76mentioning

confidence: 99%

Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

Chan

Woo

et al. 2011

J Hum Hypertens

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Vitamin D status, parathyroid hormone (PTH) level and their associations with blood pressure in Chinese population are unknown. This study examined these associations in older Chinese men. Blood pressure, serum 25-hydroxyvitamin D (25OHD) and PTH was measured in 939 community-dwelling Chinese men aged 65 years and older. Linear regression analyses were performed with adjustments for age, body mass index, education, season of measurement, medication use, self-reported history of stroke and Parkinson's disease, and other lifestyle factors. In either crude or adjusted models, serum 25OHD was not associated with blood pressure, whereas increasing PTH levels was associated with higher blood pressure. Men in the highest quartile of serum PTH level had a mean difference of 3.4 mm Hg and 2.8 mm Hg higher in as systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively, than men in the lowest quartile of serum PTH level (P trend ¼ 0.019 for SBP and o0.001 for DBP). In conclusion, the findings support an association between serum PTH and blood pressure, but not for serum 25OHD in older Chinese men whose vitamin D status is optimal. The lack of association between serum 25OHD and blood pressure may possibly because of the relatively high serum 25OHD levels of the study sample.

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“…Both endothelial cells and vascular smooth muscle cells (VSMCs) express high-affinity receptors for 1,25(OH) 2 vitamin D 3 , 1,2 and vitamin D metabolites exert numerous effects in VSMCs [3][4][5][6][7][8][9][10] that involve vital aspects of VSMC function and pathology, including contractility, growth and migration, and the evolution of vascular calcifications. Vitamin D metabolites appear to enhance the expression of Ca-ATPase, 3 increase the entry of calcium into the cell, 4 raise cytosolic free calcium, 5 induce the expression of contractile proteins, 6 and accelerate the formation of prostacyclin 7 in VSMCs, all of which may directly or indirectly affect arterial tone. Evidence also suggests that 1,25(OH) 2 vitamin D 3 inhibits VSMC replication 8,9 and diminishes the mitogenic response to growth enhancers such as thrombin or platelet-derived growth factor (PDGF).…”

mentioning

confidence: 99%

25-Hydroxyvitamin D ₃ -1α-Hydroxylase Is Expressed in Human Vascular Smooth Muscle Cells and Is Upregulated by Parathyroid Hormone and Estrogenic Compounds

et al. 2005

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Vitamin D3 stimulates the production of prostacyclin by vascular smooth muscle cells

Cited by 71 publications

References 34 publications

Flow-Mediated Vasodilation in End-Stage Renal Disease

Flow-Mediated Vasodilation in End-Stage Renal Disease

Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

25-Hydroxyvitamin D ₃ -1α-Hydroxylase Is Expressed in Human Vascular Smooth Muscle Cells and Is Upregulated by Parathyroid Hormone and Estrogenic Compounds

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Vitamin D3 stimulates the production of prostacyclin by vascular smooth muscle cells

Cited by 71 publications

References 34 publications

Flow-Mediated Vasodilation in End-Stage Renal Disease

Flow-Mediated Vasodilation in End-Stage Renal Disease

Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

25-Hydroxyvitamin D 3 -1α-Hydroxylase Is Expressed in Human Vascular Smooth Muscle Cells and Is Upregulated by Parathyroid Hormone and Estrogenic Compounds

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25-Hydroxyvitamin D ₃ -1α-Hydroxylase Is Expressed in Human Vascular Smooth Muscle Cells and Is Upregulated by Parathyroid Hormone and Estrogenic Compounds