Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

Chan, Randolph C. H.; Chan, Daniel; Woo, Jean; Ohlsson, Claes; Mellström, Dan; Leung, Ping Chung

doi:10.1038/jhh.2010.126

Cited by 36 publications

(36 citation statements)

References 38 publications

(50 reference statements)

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“…However, in agreement with the present study, two large cross-sectional studies, the Amsterdam Longitudinal Aging Study and the Rancho-Bernardo Study, did not document a significant association (16,17). To the best of our knowledge, there are a handful of studies that have focused on the relationship between vitamin D and hypertension in ethnic Chinese patients (29)(30)(31). In accordance with the present study, Li et There are several potential explanations for the lack of an association between vitamin D and hypertension observed in this study.…”

Section: Discussionsupporting

confidence: 76%

Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

et al. 2016

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Objective The aim of this study was to evaluate the vitamin D status and the relationship between the vitamin D status and hypertension in a relatively large cohort in northern China. Methods This study was a part of the Kailuan study, consisting of 3,788 coal mine workers (including 2,532 underground workers and 1,256 surface workers) who received periodic health examinations between September 13, 2012 and December 24, 2012. Information on demographic factors, personal history and medical history were collected. The height, weight, blood pressure and serum25-hydroxyvitamin D [25(OH) D] level of each patient were measured. Results The mean 25(OH)D level in this cohort was 21.73±15.82 nmol/L. The number (%) of patients with vitamin D deficiency, insufficiency, inadequacy and sufficiency were 2,509 (66.24%), 1,051 (27.75%), 201 (5.31%) and 27 (0.71%), respectively. In all the participants, after adjusting for the age, salt intake, physical activity, smoking status, alcohol drinking status, work type, work environment, body mass index, diabetes and hyperlipidemia, the odds ratios for hypertension with 25(OH)D level ! 50, 25-50 and <25 nmol/L were 1.00 (reference), 1.44 (95%CI, 0.99-2.11) and 1.39 (95%CI, 0.97-1.99), respectively. Logistic regression models to evaluate the odds ratios and 95% CIs of hypertension for each quintile of the 25(OH)D level did not determine significant associations between the vitamin D status and hypertension. No significant associations were found in the underground workers or in the surface workers. Conclusion There was a high proportion of coal mine workers with vitamin D deficiency and insufficiency in Kailuan. However, no significant association between low vitamin D levels and hypertension was found in this cohort. Further investigations are needed to determine the relationship between vitamin D levels and hypertension.

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Section: Discussionsupporting

confidence: 76%

Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

et al. 2016

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“…4 In Hong Kong, over 60% of community dwelling Chinese adult have 25(OH)D level below 75 nmol/L. 8,9 In this study, over 90% Chinese renal transplant recipients had insufficient 25(OH)D level. There was no significant difference in the 25(OH)D level between renal transplant patients and healthy controls when stratified according to the stage of CKD.…”

Section: Discussionmentioning

confidence: 97%

“…Many factors may contribute to the high prevalence of vitamin D insufficiency in southern Chinese. 8,9 These include a low level of outdoor physical activity, use of sunscreen, and the Chinese diet that is low in calcium content and lacks vitamin D-rich food items.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Vitamin D Insufficiency in Southern Chinese Renal Transplant Recipients

et al. 2012

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Vitamin D deficiency is common globally. There is evidence that vitamin D status may be related to immune function and cardiovascular disease. The vitamin D status of Chinese kidney transplant recipients has never been investigated. We performed a cross-sectional study and measured the level of 25-hydroxyvitamin D [25(OH)D] in 94 Chinese renal transplant recipients with stable allograft function. Vitamin D deficiency and insufficiency were detected in 43.6% and 54.2% of patients, respectively. About 53.2% of the patients also had elevated parathyroid hormone (PTH) levels. The level of 25(OH)D was lower in kidney transplant recipients compared with healthy controls matched for age and sex (52.5 ± 15.6 nmol/L vs. 57.5 ± 19.0 nmol/L, p = 0.05), but the level of serum creatinine was higher in kidney transplant recipients (120.3 ± 48.5 μmol/L and 78.3 ± 15.3 μmol/L, p < 0.01). The level of 25(OH)D was negatively correlated with that of PTH (p = 0.001). The latter was associated with serum creatinine (p = 0.001) and duration of dialysis (p = 0.001). Patients with a history of acute rejection showed lower levels of 25(OH)D (45.3 ± 11.9 nmol/L vs. 54.2 ± 16.0 nmol/L, p = 0.003). We conclude that vitamin D deficiency is prevalent among Chinese renal transplant recipients. In view of the potential immunomodulatory effect of vitamin D, the relationship between vitamin D level and rejection and the effect of vitamin D supplementation in renal transplant recipients warrant further investigations.

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“…It resulted in increased bone resorption and high bone fragility and fracture risk. Recent studies indicated that hyperparathyroidism was linked to the increase of systolic blood pressure and diastolic blood pressure [8], and the correlations between serum PTH and blood pressure was approved in another research on Chinese elderly people [9]. The serum PTH of overweight elderly people was higher than those of normal-weight elderly people; therefore the occurrence rate of hypertension was higher in overweight elderly people.…”

Section: Discussionmentioning

confidence: 98%

The Relationship between Serum 25(OH)D, PTH and Calculated HOMA-IR in Overweight Elderly Patients

Jiang¹,

Peng²

2016

J Aging Sci

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Background: Vitamin D deficiency or insufficiency was commonly found among adults and particularly overweight elderly patients. It's controversial on the physiological roles of vitamin D and parathyroid hormone (PTH) in metabolic diseases. We explored the relationship between serum 25-hydroxyvitamin D [25(OH)D], PTH and homeostasis model of assessment for insulin resistance index (HOMA-IR) in overweight elderly patients.

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Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

Cited by 36 publications

References 38 publications

Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

High Prevalence of Vitamin D Insufficiency in Southern Chinese Renal Transplant Recipients

The Relationship between Serum 25(OH)D, PTH and Calculated HOMA-IR in Overweight Elderly Patients

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