Vitamin D3 attenuates oxidative stress and regulates glucose level and leukocyte count in a semi-chronic streptozotocin-induced diabetes model

Mitrašinović-Brulić, Maja; Dervišević, Amela; Začiragić, Asija; Fočak, Muhamed; Valjevac, Amina; Hadžović-Dzuvo, Almira; Suljević, Damir

doi:10.1007/s40200-021-00814-2

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…Current mainstream studies report that 25(OH)D3 may improve IR by increasing insulin sensitivity through inhibition of inflammation [ 38 – 40 ]. 25(OH)D may reduce the extent of IR-related pathology by enhancing insulin signaling.…”

Section: Discussionmentioning

confidence: 99%

Serum 25(OH)D Levels Modify the Association between Triglyceride and IR: A Cross-Sectional Study

Gong

Tang

Jiang

et al. 2022

International Journal of Endocrinology

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Background. Triglycerides and 25(OH)D had been reported as correlates of IR, but the results suggest substantial heterogeneity across races. In addition, little research reported on whether different 25(OH)D levels affect triglycerides and IR. Therefore, a similar study on the US population would be a great addition to the current one. This study investigated the association between triglycerides and IR at different 25(OH)D levels. Methods. A total of 19,926 participants were included, each containing specific indicators for the study project. IR was estimated as a HOMA-IR index ≥2.73. Four multivariate logistic regression models were developed to analyze the association between TG and IR and whether different 25(OH)D levels influenced this association. Smoothed fitting curves were plotted. Results. Triglyceride was significantly associated with IR (OR: 1.3, 95 CI %), while this association received different 25(OH)D levels ( P for interaction <0.001). The effect value OR was 1.33 with the high levels, and its effect value OR was 1.28 with the low levels. Conclusion. This study demonstrates that triglyceride levels are significantly associated with insulin in the US adult population and can be used as a predictor of IR. This correlation was compromised at different 25 (OH)D levels, so future studies need to be explored in more ethnically diverse contexts.

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Section: Discussionmentioning

confidence: 99%

Serum 25(OH)D Levels Modify the Association between Triglyceride and IR: A Cross-Sectional Study

Gong

Tang

Jiang

et al. 2022

International Journal of Endocrinology

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“…The insights could be interpreted as follows: for example, Wu et al [47] revealed that cholecalciferol has the potential, as a clinical drug, to protect renal function in ischemia/reperfusion (I/R)-induced AKI by reducing ROS production and inhibiting oxidative stress. Other studies also suggested that vitamin D analogs could participate in the induction of intracellular free radical scavenging and attenuate kidney disorder through the downregulation of mTOR expression and autophagy-related oxidant response [48][49][50].…”

Section: Oxidative Stress Inflammation and Cytokine Stormmentioning

confidence: 99%

Pharmacological Efficacy and Mechanism of Vitamin D in the Treatment of “Kidney-Brain” Disorders

Zhang¹,

Wang²,

Zhang³

2023

Vitamin D Deficiency - New Insights

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Accumulating evidences have shown that serum 25-hydroxyvitamin D concentrations were inversely correlated with the incidence or severity of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and that vitamin D deficiency might be associated with an increased susceptibility to many of the complications accompanied by COVID-19, such as disorders in kidney and brain. Our previous experimental studies demonstrated that vitamin D and its analogs could protect from kidney diseases, neuroinflammation, and musculoskeletal disorders such as osteoporosis and muscle atrophy, through the suppressive effects on overactivation of the renin-angiotensin system (RAS) in tissues. Moreover, we published a review describing the therapeutic effects of traditional Chinese medicine (TCM) for organ injuries associated with COVID-19 by interfering with RAS. In the TCM principle “Kidney dredges brain,” this chapter will emphasize the potential preventive and therapeutic effects of vitamin D on both renal injuries and central nervous system disorders in COVID-19 patients and further elucidate the pharmacological effects with underlying mechanisms of vitamin D in “Kidney-Brain” disorders.

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Anti-inflammaging effects of vitamin D in human gingival fibroblasts with advanced glycation end product stimulation

Lu¹,

Lin²,

Ng³

et al. 2023

Journal of Dental Sciences

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Vitamin D3 attenuates oxidative stress and regulates glucose level and leukocyte count in a semi-chronic streptozotocin-induced diabetes model

Cited by 4 publications

References 44 publications

Serum 25(OH)D Levels Modify the Association between Triglyceride and IR: A Cross-Sectional Study

Serum 25(OH)D Levels Modify the Association between Triglyceride and IR: A Cross-Sectional Study

Pharmacological Efficacy and Mechanism of Vitamin D in the Treatment of “Kidney-Brain” Disorders

Anti-inflammaging effects of vitamin D in human gingival fibroblasts with advanced glycation end product stimulation

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