Anti-inflammaging effects of vitamin D in human gingival fibroblasts with advanced glycation end product stimulation

Lu, Hung-Chieh; Lin, Taichen; Ng, Min Yee; Hsieh, Chang‐Wei; Liao, Yi-Wen; Chen, Chuncheng; Yu, Cheng–Chia; Chen, Chun‐Jung

doi:10.1016/j.jds.2022.10.003

Cited by 5 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Periodontitis often arises due to the host's immune response to microbial triggers present in the dental plaque, while the accumulation of advanced glycation end product (AGE) levels in DM magnifies this host response [5]. AGEs are acknowledged for inducing inflammaging, a state constituted by low-grade chronic inflammation and pre-aging in various periodontal tissues including human gingival fibroblast, keratinocytes, and macrophages [6][7][8][9][10]. Inflammaging was believed to accelerate the progression of DP through several mechanisms, including cellular senescence and senescence-associated secretory phenotype (SASP) [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis

Ng,

Yu,

Chen

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

Periodontitis is a significant health concern for individuals with diabetes mellitus (DM), characterized by inflammation and periodontium loss. Hyperglycaemia in DM exacerbates susceptibility to periodontitis by inducing inflammaging in the host immune system. The use of erbium-doped yttrium–aluminum–garnet laser (ErL) in periodontitis treatment has gained attention, but its impact on diabetic-associated periodontitis (DP) and underlying mechanisms remain unclear. In this study, we simulated DP by exposing human periodontal ligament fibroblasts (PDLFs) to advanced glycation end products (AGEs) and lipopolysaccharides from P. gingivalis (Pg-LPS). Subsequently, we evaluated the impact of ErL on the cells’ wound healing and assessed their inflammaging markers. ErL treatment promoted wound healing and suppressed inflammaging activities, including cell senescence, IL-6 secretion, and p65 phosphorylation. Moreover, the laser-targeted cells were observed to have upregulated expression of CTBP1-AS2, which, when overexpressed, enhanced wound healing ability and repressed inflammaging. Moreover, bioinformatic analysis revealed that CTBP1-AS2 acted as a sponge for miR155 and upregulated SIRT1. In conclusion, ErL demonstrated the ability to improve wound healing and mitigate inflammaging in diabetic periodontal tissue through the CTBP1-AS2/miR-155/SIRT1 axis. Targeting this axis could represent a promising therapeutic approach for preventing periodontitis in individuals with DM.

show abstract

Section: Introductionmentioning

confidence: 99%

Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis

Ng,

Yu,

Chen

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Another in vitro study on epithelial cells has shown that calcitriol also significantly increases the production of calthelicidin LL-37 mRNA, CD14 expression, and triggers receptor expressed on myeloid cells-1 (TREM-1) in human gingival epithelial cells, suggesting that calcitriol supplementation enhances the innate immune response in the periodontium [ 112 ]. In addition, a recent study on human gingival fibroblasts has shown that Vit D exerts an anti-inflammaging effect and reduces oxidative stress through the activation of Nrf2 signaling pathway [ 132 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Vitamin D on Periodontal Inflammation: A Review

Meghil,

Cutler

2023

Pathogens

View full text Add to dashboard Cite

The active form of vitamin D is the hormonally active 1,25(OH)2D3 (Vit D) vitamin, which plays an important role in bone biology and host immunity. The vitamin D receptor (VDR) is a nuclear ligand-dependent transcription factor expressed by many cells. Ligation of VDR by VitD regulates a wide plethora of genes and physiologic functions through the formation of the complex Vit D-VDR signaling cascade. The influence of Vit D-VDR signaling in host immune response to microbial infection has been of interest to many researchers. This is particularly important in oral health and diseases, as oral mucosa is exposed to a complex microbiota, with certain species capable of causing disruption to immune homeostasis. In this review, we focus on the immune modulatory roles of Vit D in the bone degenerative oral disease, periodontitis.

show abstract

The neuroprotective effect of vitamin D in Parkinson's disease: association or causation

Hafiz

2023

Nutritional Neuroscience

View full text Add to dashboard Cite

Anti-inflammaging effects of vitamin D in human gingival fibroblasts with advanced glycation end product stimulation

Cited by 5 publications

References 48 publications

Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis

Er:YAG Laser Alleviates Inflammaging in Diabetes-Associated Periodontitis via Activation CTBP1-AS2/miR-155/SIRT1 Axis

Influence of Vitamin D on Periodontal Inflammation: A Review

The neuroprotective effect of vitamin D in Parkinson's disease: association or causation

Contact Info

Product

Resources

About