Influence of Vitamin D on Periodontal Inflammation: A Review

Meghil, Mohamed M.; Cutler, Christopher W.

doi:10.3390/pathogens12091180

Cited by 3 publications

(2 citation statements)

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“…Vitamin D alters the complex metabolic pathways of pathogens, lowering the infective microbes' metabolic activity [ 119 - 122 ]. As discussed by Tennert et al 2020 [ 103 ], a diet rich in vitamin D leads to a reduction of gingival and periodontal inflammation (Figure 4 ), and it also alters the composition of plaque by reducing the count of pathogenic bacteria, consecutively improving the periodontal health [ 123 ].…”

Section: Reviewmentioning

confidence: 99%

Vitamin D and Periodontal Health: A Systematic Review

Shah,

Poojari,

Nadig

et al. 2023

Cureus

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The role of vitamin D in maintaining gum well-being is crucial. However, scientific research reported that the connotations of cholecalciferol and periodontal health have been divested in the present literature. However, there is enormous heterogeneity in the data available. The current review aims to systematically review and appraise the available literature investigating the role of vitamin D in maintaining periodontal health. Studies included randomized controlled trials and clinical trials following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and cohort studies reporting associations between vitamin D and oral health in systemically healthy patients. Databases such as PubMed, Google Scholar, Scopus, Embase, and other sources, including hand search, were searched until May 2023 using together-equipped search sequences. Altogether, scientific articles that conform to the inclusion principles underwent a thorough eminence evaluation. All papers meeting inclusion criteria were subject to quality assessment, and the method used to assess the risk of bias was the Cochrane risk of bias tool. The search identified 1883 papers, among which 1435 were excluded after title evaluation. After abstract and title screening, 455 were excluded, and six full texts were assessed. After full-text evaluation, two articles were excluded, and only four were included. The data shows vitamin D's association with oral health maintenance. Along with its action on bone metabolism, it has extended function, which provides for its action as an anti-inflammatory agent and production of anti-microbial peptides, which help maintain oral health. Although the literature available is immense, there is enormous heterogenicity in the papers conducted to appraise the association between vitamin D and oral health. This systematic review has filtered all the data to review a few essential aspects of the role of vitamin D in maintaining oral physiology. Vitamin D has a linear relationship with periodontal health; however, the evidence is insufficient, and further studies must be done.

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Section: Reviewmentioning

confidence: 99%

Vitamin D and Periodontal Health: A Systematic Review

Shah,

Poojari,

Nadig

et al. 2023

Cureus

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“…Because vitamin D has immunomodulatory, anti-inflammatory, antiproliferative, and anti-apoptotic effects, meeting vitamin D requirements can lower the risk of gingivitis and chronic periodontitis. 8 The prevalence of vitamin D deficiency in the world's population is high; 30-50% of the population suffers from vitamin D deficiency. Vitamin D deficiency is an epidemic that affects about one billion people worldwide in both the deficiency and insufficiency categories.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D inhibits TNF-α serum level in wistar rats stimulated with Porphyromonas gingivalis

Hervina,

Syahriel,

Wedagama

et al. 2023

Majalah Kedokteran Gigi Indonesia

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Periodontitis is a chronic inflammation of the periodontal tissues initiated by increased proinflammatory cytokines such as TNF-α due to the induction of Porphyromonas gingivalis (Pg). This study aimed to analyze the effect of vitamin D (cholecalciferol) on TNF-α serum level in Wistar rats stimulated with Pg to induce periodontitis. Twenty-seven male Wistar rats (n = 27) were divided into three equal groups. Group I was healthy Wistar rats that received 2000 IU vitamin D once a day. Group II was Wistar rats stimulated with Pg and received 2000 IU vitamin D, while group III was Wistar rats stimulated with Pg but did not receive vitamin D. Blood was collected through the orbital sinus and centrifuged to get the serum. TNF-α serum levels were assessed using Elisa method on the 7th, 14th, and 28th. The data were normally distributed and homogeneous. The mean TNF-α data was analyzed for differences between groups using the one-way ANOVA and LSD post hoc test. Significant differences were seen in group II (418.49 ± 161.08 ng/mL) and group III (172.16 ± 104.18 ng/mL) on the 28th day (p = 0.001). The findings suggest that vitamin D inhibits the TNF-α serum level in Wistar rats stimulated with Pg on the 28th day.

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