Vitamin D3 and androgen receptors in testis and epididymal region of roosters (Gallus domesticus) as affected by epididymal lithiasis

Oliveira, André G.; Dornas, Rubem A.P.; Kalapothakis, Evanguedes; Hess, Rex A.; Mahecha, Germán Arturo Bohórquez; Oliveira, Cleida A.

doi:10.1016/j.anireprosci.2007.11.009

Cited by 32 publications

(35 citation statements)

References 25 publications

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“…This was supported by an IHC investigation in rats showing VDR expression in the intratubular cells but not in Leydig cells (Johnson et al 1996). However, these results are not in accordance with more recent IHC studies that all show detectable VDR expression in Leydig cells from humans, roosters, and mice (Oliveira et al 2008, Hirai et al 2009, Blomberg Jensen et al 2010b. A recent study showed presence of Vdr mRNA in Leydig cells from rats, and the abundance of Vdr in the Leydig cells was comparable with the observed expression of Vdr in immature Sertoli cells (Zanatta et al 2011a).…”

Section: Introductionmentioning

confidence: 32%

“…3; Johnson et al 1996, Nangia et al 1998, Corbett et al 2006, Blomberg Jensen et al 2010b. VDR was also detected in spermatogonia, spermatocytes, and Sertoli cells in roosters (Oliveira et al 2008). A functional role of VDR in adult germ cells is underpinned by the presence of classical VD-regulated genes such as calbindin subtypes, aromatase (CYP19A1), and the transient receptor potential cation channel subfamily V 5 (TRPV5) in both germ cells and spermatozoa (Kagi et al 1988, Li et al 2008, Carreau & Hess 2010.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is now recognized as a versatile signaling molecule rather than being solely a regulator of bone health and calcium homeostasis. One of the recently identified target areas of VD is male reproductive function. The VD receptor (VDR) and the VD metabolizing enzyme expression studies documented the presence of this system in the testes, mature spermatozoa, and ejaculatory tract, suggesting that both systemic and local VD metabolism may influence male reproductive function. However, it is still debated which cell is the main VD target in the testis and to what extent VD is important for sex hormone production and function of spermatozoa. This review summarizes descriptive studies on testicular VD metabolism and spatial distribution of VDR and the VD metabolizing enzymes in the mammalian testes and discusses mechanistic and association studies conducted in animals and humans. The reviewed evidence suggests some effects of VD on estrogen and testosterone biosynthesis and implicates involvement of both systemic and local VD metabolism in the regulation of male fertility potential.

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Section: Introductionmentioning

confidence: 32%

Section: Introductionmentioning

confidence: 99%

Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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“…Besides the fact that the formation of the calcium stones is restricted to the efferent ductules, epithelial injury as well as the occurrence of frequent mononuclear cell infiltrates adjacent to affected ductules are common features in affected animals (Janssen et al 2000, Mahecha et al 2002, Boltz et al 2004, Jackson et al 2006, Oliveira et al 2008. In birds, the efferent ductules compose up to 60% of the epididymal region (Aire 1979b.…”

Section: Introductionmentioning

confidence: 99%

“…Animals affected by this anomaly present severe testicular and epididymal alterations. Testicular damage includes dilation of seminiferous tubules, sloughing of the seminiferous epithelium, and increase in Leydig cell frequency in the interstitial tissue (Janssen et al 2000, Mahecha et al 2002, Oliveira et al 2008. The testicular alterations result in reduced fertility in affected animals (Janssen et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…This result suggested that adverse effects of epididymal lithiasis on fertility could be attributed to alterations in the production of sperm at the testicular level, but also possibly as a consequence of impaired maturation as they traverse the epididymal region. In birds, the epididymal region is composed of the rete testis, proximal and distal efferent ductules and epididymal duct (Aire 1979a, Aire & Soley 2000, which are also affected by the presence of the stones (Janssen et al 2000, Mahecha et al 2002, Oliveira et al 2008.…”

Section: Introductionmentioning

confidence: 99%

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Roosters affected by epididymal lithiasis present local alteration in vitamin D3, testosterone and estradiol levels as well as estrogen receptor 2 (β) expression

Oliveira

Dornas²,

Praes³

et al. 2011

Reproduction

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Epididymal lithiasis is a reproductive dysfunction of roosters that is associated with loss of fertility and is characterized by the formation of calcium stones in the lumen of the efferent ductules of the epididymal region. The efferent ductules of birds are responsible for the reabsorption of the fluid coming from the testis as well as luminal calcium. It has been hypothesized that the epididymal stone formation may be related to the impairment of local fluid or calcium homeostasis, which depends on hormones such as estradiol (E 2 ). Therefore, this study aimed to investigate possible alterations in the expression of ERa (ESR1) and ERb (ESR2) in the epididymal region of roosters affected by epididymal lithiasis. The study was performed by immunohistochemistry and western blotting assays. In addition, the concentrations of E 2 , vitamin D3, and testosterone, which are also key hormones in maintenance of calcium homeostasis, were determined in the plasma and epididymal region, by ELISA. It was observed that ESR2 expression is increased in all segments of the epididymal region of affected roosters, whereas ESR1 levels are not altered. Moreover, the hormone concentration profiles were changed, as in the epididymal region of roosters with lithiasis the E 2 levels were increased and vitamin D3 as well as testosterone concentrations were significantly decreased. These results suggest that a hormonal imbalance may be involved with the origin and progression of the epididymal lithiasis, possibly by affecting the local fluid or calcium homeostasis.

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Vitamin D in Male and Female Reproduction

Nandi¹

2018

Extraskeletal Effects of Vitamin D

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Vitamin D3 and androgen receptors in testis and epididymal region of roosters (Gallus domesticus) as affected by epididymal lithiasis

Cited by 32 publications

References 25 publications

Vitamin D metabolism, sex hormones, and male reproductive function

Vitamin D metabolism, sex hormones, and male reproductive function

Roosters affected by epididymal lithiasis present local alteration in vitamin D3, testosterone and estradiol levels as well as estrogen receptor 2 (β) expression

Vitamin D in Male and Female Reproduction

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