Vitamin D3 activates the autolysosomal degradation function against<i>Helicobacter pylori</i>through the PDIA3 receptor in gastric epithelial cells

Hu, Wei; Zhang, Lin; Li, Ming Xing; Shen, Jing; Liu, Xiao Dong; Xiao, Zhan; Wu, Duojie; Ho, Idy H. T.; Wu, Justin C. Y.; Cheung, CL; Zhang, Yu Chen; Lau, H. Y. A.; Ashktorab, Hassan; Smoot, Duane T.; Fang, Evandro Fei; Chan, Matthew T. V.; Gin, Tony; Gong, Wei; Wu, William K.K.; Cho, Chi Hin

doi:10.1080/15548627.2018.1557835

Cited by 109 publications

(83 citation statements)

References 59 publications

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“…25-(OH)D 3 may affect Hp infection by the following ways: 1. VitD can activate the autosomal degradation of Hp through the PDIA3 receptor in gastric epithelial cells, driving the elimination of Hp through the autosomal pathway 16 ; 2. The decomposition product VDP1 derived from VitD 3 has antibacterial effect on Hp 17 ; 3.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Zhang

Guo

et al. 2020

Pak J Med Sci

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Objective: To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis. Methods: A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children’s Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence. Results: The levels of 25-(OH) D3 in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D3 in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D3 and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D3 and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05). Conclusion: Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D3 may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients. doi: https://doi.org/10.12669/pjms.36.6.2292 How to cite this:Zhang Y, Bi B, Guo X, Zhang S. Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Zhang

Guo

et al. 2020

Pak J Med Sci

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“…H. pylori hiding in autophagosomes (Hu et al, 2019). Therefore, further studies are needed to identify additional possible mechanisms concerning the VitD3-mediated eradication of H. pylori antibioticresistant strains.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 Inhibits Helicobacter pylori Infection by Activating the VitD3/VDR-CAMP Pathway in Mice

Zhou

Zhao

et al. 2020

Front. Cell. Infect. Microbiol.

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Helicobacter pylori (H. pylori) infection is closely associated with the occurrence and development of gastric diseases. Therefore, eliminating H. pylori infection should help to prevent gastric diseases. Vitamin D3 (VitD3, 1,25(OH) 2 D 3) was previously observed to exhibit anti-H. pylori infection activity in clinic, but these results were reported in heterogeneous in vivo studies without elucidation of the underlying mechanisms. In the present study, we established H. pylori infection models in both wild-type and VDR knockdown (VDR-KD) mice, which were used to demonstrate that VitD3 inhibits H. pylori infection by enhancing the expression of VitD receptor (VDR) and cathelicidin antimicrobial peptide (CAMP). Furthermore, VDR-KD mice that exhibited lower VDR expression were more susceptible to H. pylori infection. In cultured mouse primary gastric epithelial cells, we further demonstrated that the VitD3/VDR complex binds to the CAMP promoter region to increase its expression. These data provide a mechanistic explanation of the anti-H. pylori infection activity of VitD3 at the molecular level in mice and suggest a new avenue for the clinical management of H. pylori eradication therapy.

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“…It was inferred that in H pylori infection, vitamin D may also affect H pylori by adjusting EGFR. Recently, Hu et al demonstrated that vitamin D activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells, which provided a novel pathogenic mechanism.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Yang

et al. 2019

Helicobacter

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Background Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. Methods Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English‐language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Results Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL, 95% CI = (−0.91, −0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta‐analysis results were stable and reliable. Conclusions Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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Vitamin D3 activates the autolysosomal degradation function againstHelicobacter pylorithrough the PDIA3 receptor in gastric epithelial cells

Cited by 109 publications

References 59 publications

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Vitamin D3 Inhibits Helicobacter pylori Infection by Activating the VitD3/VDR-CAMP Pathway in Mice

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

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