Vitamin D supplementation and testosterone concentrations in male human subjects

Heijboer, Annemieke C.; Oosterwerff, Mirjam M; Schroten, Nicolas F.; Eekhoff, Elisabeth M. W.; Chel, V.G.M.; Boer, Rudolf A. de; Blankenstein, Marinus A.; Lips, Paul

doi:10.1111/cen.12711

Cited by 57 publications

(53 citation statements)

References 33 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reasons for fall in serum testosterone after 6 months are not clear, especially when the earlier RCT and observational study in young and older males showed increase in serum testosterone after vitamin D supplementation . Two recent RCTs assessing the effect of vitamin D supplementation on serum testosterone reported no significant effect of vitamin D supplementation on serum testosterone in young males . Thus, three of the 4 RCTs including the present study show no significant effect of cholecalciferol supplementation on serum testosterone.…”

Section: Discussioncontrasting

confidence: 62%

Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial

Saha

Goswami

Vishnubhatla

et al. 2017

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 62%

Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial

Saha

Goswami

Vishnubhatla

et al. 2017

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…52,55 Indeed, 25-(OH)D has been significantly and positively associated with total testosterone and SHBG levels before and after adjustment for age and ethnicity, 56 although VitD supplementation per se does not appear to influence testosterone levels. 57 In addition, short-term administration of testosterone does not appear to alter 25-(OH)D levels. 58 The most intriguing finding of our study was the suboptimal 25-(OH)D values observed in both genders (males=19.48±9.51 and females=18.01±9.01, ng/ mL±SD), contrary to what would be expected in an area with abundant sunshine and a population prone to outdoor activities.…”

Section: Discussionmentioning

confidence: 96%

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Katrinaki

Kampa

Margioris

et al. 2016

View full text Add to dashboard Cite

“…Later studies among healthy European men confirmed this tendency by showing that lower levels of vitamin D were significantly correlated with lower total and free testosterone amounts (Lee et al ., ). However, after supplementing subjects with vitamin D, the increase of amount of testosterone was not statistically significant (Heijboer et al ., ). On the contrary, a study of men in China did not find correlations between 25(OH)D and testosterone levels (Yang et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Vitamin D status is not associated with reproductive parameters in young Spanish men

et al. 2019

View full text Add to dashboard Cite

Background Relatively low sperm count was reported among young Spanish men in 2013. Several potential culprits have been suggested as explanations for reported trends in sperm counts in Western men, including lifestyles. Although controversial, some studies suggest that semen parameters, such as low sperm motility or abnormal morphology, may be associated with low serum vitamin D levels. Objectives To evaluate associations between semen parameters and reproductive hormones and serum 25‐hydroxyvitamin D (25OHD) status in young Spanish men and to examine these associations in relation to dietary intake of vitamin D. Materials and methods This cross‐sectional study includes 198 university students recruited in 2010–2011 in southern Spain, who provided samples of blood and semen and food frequencies. Semen quality was evaluated by measuring volume, concentration, sperm counts, motility, and morphology, according to the WHO guidelines. Serum samples were analyzed for total 25OHD and reproductive hormones, including FSH, LH, testosterone, inhibin B, and estradiol. Dietary vitamin D intake was assessed using a validated food frequency questionnaire. Associations with semen quality and reproductive hormones were examined using linear regression, adjusting for potential confounders. Results Almost all men had adequate levels of serum vitamin D ‐ only three men (1.5%) were vitamin D deficient (<30 nmol/L) and 17% were insufficient (<50 nmol/L). However, dietary vitamin D intakes were relatively low (below recommended 600 IU/day in 99% of men). Neither dietary intake nor serum vitamin D levels were associated with any sperm parameter or any reproductive hormone (all p ≥ 0.09). Discussion We did not observe an association between vitamin D status and any reproductive parameter in our study population. Conclusions Our results suggest that serum vitamin D levels are sustained in Spanish men despite low dietary intake and therefore low vitamin D does not explain the poor semen quality previously observed in these young Spanish men.

show abstract

Vitamin D supplementation and testosterone concentrations in male human subjects

Abstract: In this post hoc analysis of three small clinical trials of limited duration in men with normal baseline testosterone concentrations, vitamin D supplementation was not associated with an increase in circulating testosterone concentrations.

Cited by 57 publications

References 33 publications

Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial

Vitamin D and calcium supplementation, skeletal muscle strength and serum testosterone in young healthy adult males: Randomized control trial

Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values

Vitamin D status is not associated with reproductive parameters in young Spanish men

Contact Info

Product

Resources

About