Vitamin D supplement improved testicular function in diabetic rats

Ding, Chenzhao; Wang, Qinzhu; Hao, Yiming; Wu, Lina; Du, Mengmeng; Li, Wen; Wu, Yang; Guo, Feng; Ma, Siyuan; Huang, Fengjuan; Qin, Guijun

doi:10.1016/j.bbrc.2016.03.072

Cited by 32 publications

(33 citation statements)

References 25 publications

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“…It has been known for many years that vitamin D is essential to maintain reproductive functions in male rats (Kwiecinski et al ., ; Fu et al ., ). However, the mechanism through which vitamin D affects male reproductive functions remains unclear (Ding et al ., ; Fu et al ., ). It has been suggested that vitamin D affects function and survival of mature spermatozoa (Blomberg Jensen et al ., , ).…”

Section: Discussionmentioning

confidence: 97%

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Vitamin D status is not associated with reproductive parameters in young Spanish men

et al. 2019

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Background Relatively low sperm count was reported among young Spanish men in 2013. Several potential culprits have been suggested as explanations for reported trends in sperm counts in Western men, including lifestyles. Although controversial, some studies suggest that semen parameters, such as low sperm motility or abnormal morphology, may be associated with low serum vitamin D levels. Objectives To evaluate associations between semen parameters and reproductive hormones and serum 25‐hydroxyvitamin D (25OHD) status in young Spanish men and to examine these associations in relation to dietary intake of vitamin D. Materials and methods This cross‐sectional study includes 198 university students recruited in 2010–2011 in southern Spain, who provided samples of blood and semen and food frequencies. Semen quality was evaluated by measuring volume, concentration, sperm counts, motility, and morphology, according to the WHO guidelines. Serum samples were analyzed for total 25OHD and reproductive hormones, including FSH, LH, testosterone, inhibin B, and estradiol. Dietary vitamin D intake was assessed using a validated food frequency questionnaire. Associations with semen quality and reproductive hormones were examined using linear regression, adjusting for potential confounders. Results Almost all men had adequate levels of serum vitamin D ‐ only three men (1.5%) were vitamin D deficient (<30 nmol/L) and 17% were insufficient (<50 nmol/L). However, dietary vitamin D intakes were relatively low (below recommended 600 IU/day in 99% of men). Neither dietary intake nor serum vitamin D levels were associated with any sperm parameter or any reproductive hormone (all p ≥ 0.09). Discussion We did not observe an association between vitamin D status and any reproductive parameter in our study population. Conclusions Our results suggest that serum vitamin D levels are sustained in Spanish men despite low dietary intake and therefore low vitamin D does not explain the poor semen quality previously observed in these young Spanish men.

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Section: Discussionmentioning

confidence: 97%

“…(Kwiecinski et al, 1989;Fu et al, 2017). However, the mechanism through which vitamin D affects male reproductive functions remains unclear (Ding et al, 2016;Fu et al, 2017). It has been suggested that vitamin D affects function and survival of mature spermatozoa (Blomberg Jensen et al, 2011, 2016.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status is not associated with reproductive parameters in young Spanish men

et al. 2019

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“…[26] The latter study indicated that VD played a protective role for testes and against testicular damage induced by diabetes, and the possible mechanism might be effective through regulating attenuation of inflammation and inactivating caspase cascade. [26] Emerging data suggests that VD has a potential role in regulating inflammation. In research, it was shown that VD inhibits the expression of inflammatory cytokines in monocytes, including IL-1, IL-6, TNF-α, IL-8, and IL-12.…”

Section: Vitamin D and Endocrine Systemmentioning

confidence: 91%

“…In an animal study on diabetic rats, it was demonstrated that treatment with VD for 12 weeks increased the serum level of T in treatment groups. [26] In a clini- Abnormalities in calcium and phosphorus homeostasis [10,15] Bronchial asthma [4,7] Coronary artery disease [14,16] Erectile dysfunction [9,17,18] Heart failure [10,16] Hypertension [9,14] Hypogonadism [19][20][21][22] Impaired vascular endothelial and smooth muscle function [9,16] Increased immune or inflammatory response [23,24] Infertility [25,26] Metabolic syndrome [10,14,27] Osteoporosis [19,28,29] Peripheral vascular disease [15,30] Respiratory diseases [3,4] Wearing sunscreen clothes cal randomized controlled trial, which is the first on this topic in literature, Pilz et al [39] investigated the effect of VD supplementation on androgens in men. The results were significant and the researchers observed that overweight men with VDD had a clinically meaningful increase in serum T levels after VD supplementation for 1 year.…”

Section: Vitamin D and Endocrine Systemmentioning

confidence: 99%

The role of vitamin D supplementation on erectile function

Talib

Khalafalla

Cangüven

2017

Turkish Journal of Urology

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In the last few years growing evidence highlighted vitamin D (VD) deficiency is one of the several dynamics that associates with increased atherosclerotic cardiovascular (ASCV) diseases. ASCV diseases and erectile dysfunction (ED) share common risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle. The aim of this review was to summarize current progress in VD research by focusing effect of low VD level on different body systems and erectile function. Here we examine research linking VD deficiency and ED and discuss how VD influences ED and its classic risk factors that also associate to increased ED risk. We also summarize research indicating that VD associates with reduced risk of several nonvascular contributing factors for ED. Available literature demonstrates relatively high rates of low VD serum levels in ED patients. Based on the preclinical and clinical data available in the literature, to date, we infer that VD play a critical role in maintaining erectile function in humans. Nevertheless, this should also be tested through randomized controlled studies on the effect of VD supplementation with larger population.

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“…Research has shown that DM impairs several aspects of the male reproductive function (Nna et al ., ). Decreased daily sperm production, sperm count, motility and viability, increased sperm abnormal morphology, DNA fragmentation, and reduced fertility potential have all been reported in DM (Karimi et al ., ; Ding et al ., ; Reddy et al ., ; Joshi et al ., ). These negative effects have been linked to oxidative stress, which accompanies the disease (Vignera et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Down‐regulation of steroidogenesis‐related genes and its accompanying fertility decline in streptozotocin‐induced diabetic male rats: ameliorative effect of metformin

et al. 2018

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Background: Metformin has long been used for glycemic control in diabetic state. Recently, other benefits of metformin beyond blood glucose regulation have emerged. Objectives: To investigate the effect of metformin on the expression of testicular steroidogenesis-related genes, spermatogenesis, and fertility of male diabetic rats. Materials and methods: Eighteen adult male Sprague Dawley rats were divided into three groups, namely normal control (NC), diabetic control (DC), and metformin-treated (300 mg/kg body weight/day) diabetic rats (D+Met). Diabetes was induced using a single intraperitoneal injection of streptozotocin (60 mg/kg b.w.), followed by oral treatment with metformin for four weeks. Results: Diabetes decreased serum and intratesticular testosterone levels and increased serum but not intratesticular levels of luteinizing hormone. Sperm count, motility, viability, and normal morphology were decreased, while sperm nuclear DNA fragmentation was increased in DC group, relative to NC group. Testicular mRNA levels of androgen receptor, luteinizing hormone receptor, cytochrome P450 enzyme (CYP11A1), steroidogenic acute regulatory (StAR) protein, 3b-hydroxysteroid dehydrogenase (HSD), and 17b-HSD, as well as the level of StAR protein and activities of CYP11A1, 3b-HSD, and 17b-HSD, were decreased in DC group. Similarly, decreased activities of epididymal antioxidant enzymes and increased lipid peroxidation were observed in DC group. Consequently, decreased litter size, fetal weight, mating and fertility indices, and increased pre-and post-implantation losses were recorded in DC group. Following intervention with metformin, we observed increases in serum and intratesticular testosterone levels, Leydig cell count, improved sperm parameters, and decreased sperm nuclear DNA fragmentation. Furthermore, mRNA levels and activities of steroidogenesis-related enzymes were increased, with improved fertility outcome. Discussion and conclusion: Diabetes mellitus is associated with dysregulation of steroidogenesis, abnormal spermatogenesis, and fertility decline. Controlling hyperglycemia is therefore crucial in preserving male reproductive function. Metformin not only regulates blood glucose level, but also preserves male fertility in diabetic state. Research has shown that DM impairs several aspects of the male reproductive function (Nna et al., 2017a). Decreased daily sperm production, sperm count, motility and viability, increased 110

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Vitamin D supplement improved testicular function in diabetic rats

Cited by 32 publications

References 25 publications

Vitamin D status is not associated with reproductive parameters in young Spanish men

Vitamin D status is not associated with reproductive parameters in young Spanish men

The role of vitamin D supplementation on erectile function

Down‐regulation of steroidogenesis‐related genes and its accompanying fertility decline in streptozotocin‐induced diabetic male rats: ameliorative effect of metformin

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