The role of vitamin D supplementation on erectile function

Talib, Raidh A.; Khalafalla, Kareim; Cangüven, Önder

doi:10.5152/tud.2017.76032

Cited by 19 publications

(17 citation statements)

References 53 publications

(100 reference statements)

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“…Of note, the antioxidant pathway of vitamin D is also mediated by the activation of the Mek/Erk-Sirt1 axis [ 24 ]. In addition, activated vitamin D stimulates the production of nitric oxide in endothelial cells and nitric oxide synthases, a key process to penile vascular dilation [ 25 , 26 ]. Furthermore, it also plausible that vitamin D binds directly to the androgen receptor as suggested by computer (in silico) models which show that besides activating the vitamin D receptor, 1,25(OH) vitamin D also has affinity for several other nuclear receptors, such as ɑ / β thyroid receptors, glucocorticoid receptor, and androgen receptor.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Tirabassi

Sudano

Salvio

et al. 2018

International Journal of Endocrinology

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Background The effects of vitamin D on sexual function are very unclear. Therefore, we aimed at evaluating the possible association between vitamin D and sexual function and at assessing the influence of vitamin D administration on sexual function. Methods We retrospectively studied 114 men by evaluating clinical, biochemical, and sexual parameters. A subsample (n = 41) was also studied longitudinally before and after vitamin D replacement therapy. Results In the whole sample, after performing logistic regression models, higher levels of 25(OH) vitamin D were significantly associated with high values of total testosterone and of all the International Index of Erectile Function (IIEF) questionnaire parameters. On the other hand, higher levels of total testosterone were positively and significantly associated with high levels of erectile function and IIEF total score. After vitamin D replacement therapy, total and free testosterone increased and erectile function improved, whereas other sexual parameters did not change significantly. At logistic regression analysis, higher levels of vitamin D increase (Δ-) were significantly associated with high values of Δ-erectile function after adjustment for Δ-testosterone. Conclusions Vitamin D is important for the wellness of male sexual function, and vitamin D administration improves sexual function.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Tirabassi

Sudano

Salvio

et al. 2018

International Journal of Endocrinology

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“…In addition, a study in diabetic rats showed the ability of maxacalcitol, an analogue of vitamin D, to improve the antioxidant pathway of nuclear factor erythroid 2-related factor 2 (Nrf2) [31]. Inflammation can exert its detrimental action on the endothelium through both chronic low-grade inflammation, associated with atherosclerotic mechanisms, and by the acute systemic inflammatory response [32]. Vitamin D exerts an immunomodulatory action thus reducing inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, it has been shown that vitamin D is able to stimulate the expression eNOS and therefore the production of nitric oxide (NO), a key molecule in the erectile response. Hence the reduction of NO production in patients with vitamin D deficiency could be another mechanism that explains its correlation with ED [32].…”

Section: Discussionmentioning

confidence: 99%

Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis

et al. 2020

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Erectile dysfunction (ED) is found very frequently in the male population, in particular in its arteriogenic form, which also represents an important predictor of cardiovascular diseases (CVDs). Some evidence suggests that vitamin D could play a role in cardiovascular risk prevention thanks to its ability to reduce endothelial damage, oxidative stress, the production of inflammatory cytokines, and dyslipidemia. Since ED and CVDs have pathogenic mechanisms in common, numerous studies have evaluated a possible association between vitamin D deficiency (blood concentrations of 25-hydroxyvitamin D < 20 ng/mL) and ED, but with conflicting results. This meta-analysis was therefore performed to clarify the discrepancy of the data so far published. To achieve this, articles have been searched extensively in the Pubmed, MEDLINE, Cochrane, Academic One Files, Google Scholar, and Scopus databases from the first day they were created until January 2020. The search strategy included pertinent Medical Subjects Headings (MeSH) terms. Of the 431 items retrieved, only eight observational studies were included, resulting in a total sample size of 4055 patients. It was found that 25-hydroxyvitaminD (25(OH)D) levels did not show any significant difference between patients with and without ED. However, when patients with vitamin D deficiency only were taken into account, the international index of erectile function (IIEF) score for erectile dysfunction was significantly worse than in controls. This association remained significant even when eugonadal-only patients were considered. Finally, we found that eugonadal patients with severe ED have lower 25(OH)D3 levels than patients with mild ED. In conclusion, this meta-analysis suggests an association between vitamin D deficiency and the presence of severe forms of ED, independent of testicular function.

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“…Khazan 2015). In diabetics the anti-inflammatory effects of NO are very beneficial (Talib 2017). The high level of NO is toxic for health and can cause bodily dysfunction (Khazan 2015).…”

Section: Polymorphism Vdr Fokimentioning

confidence: 99%

The Effect of Vitamin D and FokI Vitamin D Receptor Polymorphism to 25 (OH) D, TNF-α and Nitric Oxide Levels in Diabetic Foot Patients

Raflis¹,

Tjprc²

2019

IJMPS

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Vitamin D receptors thought to reduce the inflammatory process activity of diabetic foot ulcers which is influenced by vitamin D receptor polymorphism (VDR). The inflammatory indicators that play a role, including TNF-α and Nitric Oxide (NO), while the VDR gene that mostly studied concerning type 2 DM is FokI variant. This study aimed to analyze the effect of oral vitamin D administration on levels of 25 (OH) D, TNF-α, and NO through VDR Fok-I genetic polymorphism in patients with diabetic foot ulcers. This experimental study used the pre and post-test control group design method with 36 diabetic foot patients of West Sumatera, Indonesia, who randomly divided into two groups, namely the group given once only100, 000 IU vitamin D3, and the control group was given once only placebo capsules before blood examination. Each respondent was examined for blood for levels of 25 (OH) D, TNF-α, NO, VDR FokI gene polymorphism (PCR analysis and sequencing). Blood tests were taken before treatment (H0) and four weeks later (H28). The results showed that the most VDRFokI gene polymorphisms were heterozygous mutant types followed by wild-type and homozygous mutants. Giving vitamin D increases levels of 25 (OH) D and NO, but does not reduce levels of TNF-α. There is no effect of VDR FokI gene polymorphism on levels of 25 (OH) D, TNF-α, and NO levels. CONCLUSIONS Administration of vitamin D is beneficial in diabetic foot patients to increase levels of 25 (OH) D and Nitric oxide (NO) oxide, but not affected by the VDR FokI genetic polymorphism.

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The role of vitamin D supplementation on erectile function

Cited by 19 publications

References 53 publications

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study

Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis

The Effect of Vitamin D and FokI Vitamin D Receptor Polymorphism to 25 (OH) D, TNF-α and Nitric Oxide Levels in Diabetic Foot Patients

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