Vitamin D sufficiency is associated with low incidence of limb and vertebral fractures in community-dwelling elderly Japanese women: the Muramatsu Study

Abstract

Sufficient vitamin D status, i.e., serum 25(OH)D ≥ 71 nmol/L, is associated with low limb and vertebral fracture risk in community-dwelling elderly women.

Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

“…17 Nonetheless, because lower 25(OH)D levels increase the risk of hip and vertebral fractures in the elderly population, our analysis suggests that vitamin D insufficiency in younger individuals should be corrected to prevent future osteoporosis and fractures. [2][3][4] Vitamin D sufficiency is reportedly associated with a low incidence of limb and vertebral fractures, 11 suggesting that vitamin D supplementation in younger women could reduce fracture risk in the future. It has also been reported that serum vitamin D levels are significantly low, and intact PTH levels are significantly high, in hip fracture patients compared to controls, [1][2][3] suggesting that this condition is a risk factor for hip fracture.…”

“…The mean age was 48.18 years ( Table 1), which was much younger than that of other studies, which have primarily included patients over 70 years of age who exhibited osteoporosis or existing fractures. [2][3][4]11 The subjects' mean height, weight, and BMI were 157.92 cm, 53.94 kg, and 21.62 kg/m 2 , respectively ( Table 1). Subjects had no history of fragile fracture or history of bone metabolism-related diseases such as diabetes mellitus, collagen disease, liver and/or renal dysfunction, or steroid treatment.…”

“…Because serum PTH and 25(OH)D levels are inversely correlated, 8 correction of low vitamin D levels may counteract high PTH levels. Indeed, serum vitamin D sufficiency is reportedly associated with low incidences of limb and vertebral fractures in elderly women, 11 further suggesting that serum vitamin D status is closely related to fracture risk. However, since these studies have been conducted primarily in elderly patients or patients with fractures, most of whom were more than 70 years old, the serum vitamin D status in younger women remains largely unknown.…”

Assessment criteria for vitamin D deficiency/insufficiency in Japan — proposal by an expert panel supported by Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, The Japanese Society for Bone and Mineral Research and The Japan Endocrine Society [Opinion]

“…lent fractures was 14.6 ng/mL, which was significantly lower than that in those without. Muramatsu study [15], a 6-year cohort study of 773 community dwelling women in Niigata prefecture, revealed that fracture risk was significantly lower in subjects with basal serum 25(OH)D level being more than 28.4 ng/mL compared with the others with lower 25(OH)D level, with the hazard ratio of 0.41 (95% CI 0.18-0.91). Another cohort study of 1,470 postmenopausal women conducted in Nagano prefecture with a mean observation period of 7.2 years [16] revealed that those with basal serum 25(OH)D level less than 25 ng/mL showed a significantly higher risk of long-bone fracture.…”

The association of serum 25-hydroxyvitamin D and vertebral fractures in patients with type 2 diabetes

“…There is contradictory evidence on the association between vitamin D deficiency and osteoporotic fracture incidence. Many prospective cohort studies have reported that low serum 25-hydroxyvitamin D [25(OH) D] levels were associated with osteoporotic fractures in the elderly [5][6][7][8][9], while others have not [10,11].…”