Vitamin D Status of Patients Admitted to a Hospital Rehabilitation Unit

Vallero

American Journal of Physical Medicine &Amp; Rehabilitation

et al. 2011

Section: Discussionsupporting

confidence: 92%

The Burden of Prevalent Vertebral Fractures is Negatively Associated with Functional Outcome in Women with Hip Fracture

Vallero

American Journal of Physical Medicine &Amp; Rehabilitation

et al. 2011

Iran Red Crescent Med J

“…Several additio-l studies have shown that the prevalence of vitamin D deficiency is high in patients admitted to the hospital (25)(26)(27). Ginde et al investigated the hypothesis that in patients with suspected infection and a serum 25 (OH) D level of < 75 nmol/L, a more severe infection might be present.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Evaluation of the Relationship Between Serum Vitamin D Level and Severity of Sepsis

Ahmadi

Doluee

Pouryaghobi

et al. 2016

Background: On the basis of the literature, vitamin D is known as an important medium in bodily immune function, and it therefore may play a role in the pathogenesis of sepsis. Objectives: In this study, we aimed to evaluate the relationship between vitamin D serum levels and sepsis severity. Patients and Methods:This study was a case-control study that evaluated adult patients admitted to the emergency department of Imam Reza hospital with suspected sepsis. These patients were enrolled in the study as the case group. In addition, healthy individuals without the sepsis diagnostic criteria were included in the control group. For all of the study participants, vitamin D levels were evaluated. The acute physiology age chronic health evaluation (APACHE) was used to evaluate disease severity in the case group. A difference of P < 0.05 was regarded as statistically significant. Results: A total of 112 patients were assessed: 56 in the control group and 56 in the case group. In the case group, 18 patients had sepsis, 25 patients had severe sepsis, and 13 patients were in septic shock. The mean ages of the patients in the case and control groups were 57.7 ± 15.15 and 58.6 ± 15.05 years, respectively (P = 0.741). Vitamin D levels in the case group were lower than in the control group (16.3 ± 10.7 versus 27.9 ± 11.46 ng/mL), and the difference between the groups was significant (P < 0.001). Mean vitamin D levels in the severe sepsis and septic shock groups were lower than in the sepsis group, and the mean level in the septic shock group was lower than in the severe sepsis group (P = 0.001). In the case group, there was a significant reverse correlation between APACHE II criteria and vitamin D levels (P < 0.001, r = -0.586). Conclusions:The results of this study indicated that patients with sepsis had lower serum vitamin D levels than healthy controls. Also, patients with more severe disease had lower serum vitamin D levels, but to evaluate causation and determine whether vitamin D supplementation could be effective in reducing the risk or severity of sepsis, randomized controlled trials should be conducted.

“…66 Those with higher 25(OH)D levels upon admission to hospitals have shorter lengths of stay. 67 A metaanalysis of vitamin D supplements on mortality rates found that relative risk for mortality from any cause was 093 (95% CI, 0.87-99) for a mean dose of 528 IU of vitamin D per day over a mean period of 5.7 years for people older than 47 years at enrollment. 68 A more recent study in the United States found a 26% increased rate of allcause mortality (mortality rate ratio, 1.26; 95% CI, 1.08-1.46) for serum 25(OH)D <17.8 ng/mL compared to >32.1 ng/mL.…”

Section: Trendsmentioning

confidence: 99%

Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia

Grant

2009

Dermato-Endocrinology

The primary features of the epidemiology of septicemia in the United States include highest rates in winter and the Northeast, lowest in fall and in the West; higher rates among African Americans than white Americans; a rapid increase in incidence with age; comorbidity with several chronic and infectious diseases; and a rapid increase in incidence rate starting in the early 1980s. This article reviews the literature on the epidemiology of septicemia in the United States, along with the roles of solar ultraviolet-B (UVB) and vitamin D3 related to the more important features. Solar UVB doses in summer are highest in the Southwest and lowest in the Northeast. Serum 25-hydroxyvitamin D [25(OH)D] levels are highest in summer, lowest in winter. African Americans have much lower 25(OH)D levels than those of white Americans. Serum 25(OH)D levels decline rapidly with advancing age. The risk of diseases comorbid with septicemia are generally inversely correlated with serum 25(OH)D levels. Sun-avoidance messages may have led to lower population levels of 25(OH)D, although prevalence of antibiotic-resistant bacteria may have increased. Previous reports have shown that 1,25-dihydroxyvitamin D upregulates human cathelicidin, LL-37, which has antimicrobial as well as antiendotoxin activity. The general agreement between the epidemiology of septicemia in the United States and the variations of solar UVB and the effects of vitamin D supports the hypothesis that both play important roles in reducing the risk of septicemia. Further study is warranted to evaluate this hypothesis.