Vitamin D Status Is Positively Associated with Calcium Absorption among Postmenopausal Thai Women with Low Calcium Intakes,

Sirichakwal, Prapaisri P; Kamchansuppasin, Achiraya; Akoh, Christine C.; Kriengsinyos, Wantanee; Charoenkiatkul, Somsri; O’Brien, Kimberly

doi:10.3945/jn.114.207290

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…A possible mechanism for these observations could involve hepcidin inhibition of iron and intracellular ROS levels, which increases bone formation and decreases bone resorption and results in elevated bone mass. Compared with traditional osteoporosis therapies, such as calcium and vitamin D supplements, for inhibiting osteoclast activity or promoting osteoblast bone formation function, this novel iron reduction method seems suitable for postmenopausal osteoporosis , Song et al 2014, Sirichakwal et al 2015, Miller et al 2016. It has been reported that postmenopausal women often suffer from iron accumulation, and traditional treatment has often been ineffective for such patients.…”

Section: Discussionmentioning

confidence: 99%

Hepcidin is an endogenous protective factor for osteoporosis by reducing iron levels

Zhang

Wang

et al. 2018

Journal of Molecular Endocrinology

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Postmenopausal osteoporosis is a global health issue. Although a lack of estrogen is considered the major reason for postmenopausal osteoporosis, other factors might also contribute the etiology of the disease. In previous reports, we and others proposed that iron accumulation after menopause accelerates osteoporosis, and here, we genetically modified the expression of an endogenous hormone, hepcidin, to modulate iron status in a mouse model. Our results show that hepcidin levels negatively correlate with bone loss in both knockout and overexpression (with ovariectomy) murine models. In addition, iron overload enhances reactive oxygen species (ROS) activity and attenuates the functions of primary osteoblasts, while iron depletion could reverse this phenomenon through inhibiting the functions of primary osteoclasts. Therefore, our results provide more evidence of the 'iron accumulation' hypothesis, which suggests that high iron levels are risk factors for osteoporosis, and the 'Huang's hypothesis' that hepcidin is a potential drug target for the prevention of postmenopausal osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Hepcidin is an endogenous protective factor for osteoporosis by reducing iron levels

Zhang

Wang

et al. 2018

Journal of Molecular Endocrinology

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“…The influence of phytate was also clear for wheat flour products, which showed higher calcium absorption than wheat bran products, which are rich in phytate [ 86 ]. Data reported in Table 5 show also that foods with low amounts of both phytate and oxalate, such as cassia leaves (42.6%), winged beans (39.1%) and the ivy gourd (47.6%) have a high calcium absorption [ 81 , 114 ]. Mineral water has been shown to be a source of absorbable calcium [ 110 , 118 ] but concentrations are relatively low, so this would need considerable amounts of consumption to make meaningful contributions to overall calcium intake.…”

Section: Calcium Absorption From Foodsmentioning

confidence: 99%

Calcium Absorption from Food Products: Food Matrix Effects

2021

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This article reviews physicochemical aspects of calcium absorption from foods. Notable differences are observed between different food products in relation to calcium absorption, which range from <10% to >50% of calcium in the foods. These differences can be related to the interactions of calcium with other food components in the food matrix, which are affected by various factors, including fermentation, and how these are affected by the conditions encountered in the gastrointestinal tract. Calcium absorption in the intestine requires calcium to be in an ionized form. The low pH in the stomach is critical for solubilization and ionization of calcium salts present in foods, although calcium oxalate complexes remain insoluble and thus poorly absorbable. In addition, the rate of gastric transit can strongly affect fractional absorption of calcium and a phased release of calcium into the intestine, resulting in higher absorption levels. Dairy products are the main natural sources of dietary calcium in many diets worldwide, which is attributable to their ability to provide high levels of absorbable calcium in a single serving. For calcium from other food products, lower levels of absorbable calcium can limit contributions to bodily calcium requirements.

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“…Estrogen deficiency is one of the most important factors contributing to osteopenia and it results in various intestinal environmental changes such as alteration of gut microbiota [ 13 ]. Although estrogenic hormonal imbalance may be affected by nutrient bioavailability [ 14 , 15 ], there is a dearth of studies on the effect of physical ovariectomy (OVX) and subsequent hormonal imbalance on the bioavailability of phytochemicals such as genistein remain. One hypothesis is that OVX-induced hormonal imbalance affects gut microbiota populations, thereby affecting the bioavailability of phytochemicals such as genistein.…”

Section: Introductionmentioning

confidence: 99%

Nutrikinetic study of genistein metabolites in ovariectomized mice

et al. 2017

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This study was designed to evaluate the effect of ovariectomy on nutrikinetics of genistein metabolites. To characterize the time-dependent changes in genistein metabolite concentrations, we identified 13 genistein metabolites using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. The nutrikinetics of the individual metabolites at different time points were analyzed. Nutrikinetic analysis showed that genistein, genistein 4′-glucuronide, genistein 7-glucuronide, 3-hydroxygenistein, and hippuric acid showed relatively high bioavailability in the sham group compared to that in the ovariectomy group, suggesting that ovariectomy likely results in lower genistein bioavailability. These results may be related to alteration of gut microbiota by ovariectomy. The relative abundance of species of the Parabacteroides, Dorea, and Butyricimonas genera, and Desulfovibrionaceae_unclassified, Lachnospiraceae_unclassified, and Rikenellaceae_unclassified families increased in the ovariectomy group while the relative abundance of 523_7_unclassified and Y52_unclassified_unclassified increased in the sham group. These results suggest that gut microbiota alteration by ovariectomy may affect genistein bioavailability.

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Vitamin D Status Is Positively Associated with Calcium Absorption among Postmenopausal Thai Women with Low Calcium Intakes,

Cited by 8 publications

References 38 publications

Hepcidin is an endogenous protective factor for osteoporosis by reducing iron levels

Hepcidin is an endogenous protective factor for osteoporosis by reducing iron levels

Calcium Absorption from Food Products: Food Matrix Effects

Nutrikinetic study of genistein metabolites in ovariectomized mice

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