Vitamin D status in children with headache: A case-control study

Donmez, Ahsen; Örün, Emel; Sönmez, Fatma Müjgan

doi:10.1016/j.clnesp.2017.09.010

Cited by 30 publications

(16 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A few case‐control studies have also been done in headache patients. Sonmez et al noted significantly lower levels of vitamin D in both migraine and TTH in a case‐control study in children (published in abstract). Celikbilek et al noted significantly lower level serum 25(OH) D in patients with migraine.…”

Section: Discussionmentioning

confidence: 98%

Vitamin D Deficiency in Patients With Chronic Tension‐Type Headache: A Case‐Control Study

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Vitamin D Deficiency in Patients With Chronic Tension‐Type Headache: A Case‐Control Study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…After studying 147 patients aged 5–16 years with headaches (either tension-type or migraine) and 69 controls, Dönmez et al reported that, in conditions of low solar exposure, the relationship between headache and vitamin D deficiency was of limited significance [18].…”

Section: Discussionmentioning

confidence: 99%

“…According to few small-scale studies and reports, vitamin D therapy is beneficial for headache disorders [11,12,13,14,15]. However, very few pediatric reports are available [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Vitamin D Levels and Response to Therapy of Childhood Migraine

Kılıç

2019

Medicina

View full text Add to dashboard Cite

Background and Objectives: Vitamin D deficiency and insufficiency are related with many neurological diseases such as migraine. The aim of this study was to investigate whether pediatric migraine is associated with vitamin D deficiency and the effect of vitamin D therapy on the frequency, duration, severity of migraine attacks, and Pediatric Migraine Disability Assessment (PedMIDAS). Materials and Methods: We retrospectively examined the patients’ levels of calcium, phosphorus, parathyroid hormone, alkaline phosphatase, and 25-OH vitamin D of 92 pediatric migraine patients. The patients were divided into two groups: Group 1, which had low vitamin D levels and received vitamin D therapy, and group 2, which had normal vitamin D levels and did not receive vitamin D therapy. Migraine severity measured by the visual analog scale (VAS), migraine frequency, and duration as well as scores on the PedMIDAS questionnaire were compared with regard to the 25-OH vitamin D levels. In addition, pre- and posttreatment pedMIDAS scores, VAS, migraine frequency, and duration were compared with baseline values. Results: A total of 34.7% patients had vitamin D insufficiency (vitamin D levels between 10 and 20 ng/mL), whereas 10.8% had vitamin D deficiency (vitamin D levels < 10 ng/mL). Migraine frequency, migraine duration, and PedMIDAS scores were significantly higher in the group 1 than group 2 (p = 0.004, p = 0.008, and p = 0.001). After vitamin D therapy at sixth months of supplementation, migraine duration was reported statistically significant shorter (p < 0.001) and the migraine frequency, VAS scores, and pedMIDAS scores were statistically significant lower compared with baseline values in group 1 (p < 0.001). Conclusion: We found a marked correlation between pediatric migraine and vitamin D levels. Vitamin D therapy was beneficial in migraine pediatric patients.

show abstract

“…Based on the studies published to date and summarized in Table 1, vitamin D deficiency is common among patients with TTH: low serum 25(OH)D levels were present in 67.2-73.0% of patients [22,57,60], and ranged from 13.5 to 16.9 ng/mL. Prakash et al examined 71 patients with chronic TTH, and found significantly lower mean 25(OH)D serum levels in subjects with musculoskeletal pain coexisting with headache comparing to those with headache only [22].…”

Section: Vitamin D Deficiency and Tension-type Headachesmentioning

confidence: 99%

The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment

et al. 2020

View full text Add to dashboard Cite

Some studies have suggested a link between vitamin D and headache; however, the underlying physiological mechanisms are unclear. We aimed to summarize the available evidence on the relationship between vitamin D and the various subtypes of primary headaches, including migraines and tension-type headaches. All articles concerning the association between primary headache and vitamin D published up to October 2019 were retrieved by searching clinical databases, including: EMBASE, MEDLINE, PubMed, Google scholar, and the Cochrane library. All types of studies (i.e., observational, cross-sectional, case-control, and clinical trials) were included. We identified 22 studies investigating serum vitamin D levels in association with headaches. Eight studies also evaluated the effect of vitamin D supplementation on the various headache parameters. Among them, 18 studies showed a link between serum vitamin D levels and headaches, with the strongest connection reported between serum vitamin D levels and migraine. Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency.

show abstract

Vitamin D status in children with headache: A case-control study

Cited by 30 publications

References 22 publications

Vitamin D Deficiency in Patients With Chronic Tension‐Type Headache: A Case‐Control Study

Vitamin D Deficiency in Patients With Chronic Tension‐Type Headache: A Case‐Control Study

Evaluation of Vitamin D Levels and Response to Therapy of Childhood Migraine

The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment

Contact Info

Product

Resources

About