Vitamin D status in children with chronic kidney disease

Stein, Deborah R.; Feldman, Henry A.; Gordon, Catherine M.

doi:10.1007/s00467-012-2143-7

Cited by 19 publications

(8 citation statements)

References 29 publications

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“…Studies in children with CKD have reported variable associations between GFR and 25OHD deficiency [22, 24, 25]. In their study of 182 pediatric CKD patients, Kalkwarf et al showed that later stages of CKD (4, 5, and 5D) did associate with lower 25OHD concentrations [22].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Seeherunvong et al reported that patients with more advanced CKD (stage 3 to 5 with eGFR < 60 ml/min/1.73 m 2 ) had a higher prevalence of vitamin D deficiency than those with more moderately reduced or normal eGFR (42 vs. 26 %; p <0.05) [25]. By contrast, in a study by Stein et al, in which 70 % of children had CKD stage 1 to 3, 25OHD levels did not associate with GFR [24]. We found no association between GFR and 25OHD levels.…”

Section: Discussionmentioning

confidence: 99%

“…An inverse association of vitamin D levels with proteinuria has been reported in the adult CKD population [19, 20]. Studies of children with CKD published to date are mostly cross-sectional and report a prevalence of 25OHD deficiency that ranges from 30 to 60 % [21–24]. The reported association between 25OHD levels and GFR is variable, with some studies reporting deficiency at lower GFRs [25] and others finding no such association [26].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort

et al. 2015

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Background Vitamin D plays an important role in the mineral and bone disorder seen in chronic kidney disease (CKD). Deficiency of 25-hydroxyvitamin D (25OHD) is highly prevalent in the adult CKD population. Methods The prevalence and determinants of 25OHD deficiency (defined as a level <20 ng/ml) were examined longitudinally in 506 children in the CKiD cohort. Predictors of secondary hyperparathyroidism and the determinants of 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were also evaluated. Results Deficiency of 25OHD was observed in 28 % of the cohort at enrollment. Significant predictors of 25OHD deficiency were older age, non-white race, higher body mass index, assessment during winter, less often than daily milk intake, non-use of nutritional vitamin D supplement and proteinuria. Lower values of glomerular filtration rate (GFR), serum 25OHD, calcium and higher levels of FGF23 were significant determinants of secondary hyperparathyroidism. Lower GFR, low serum 25OHD, nephrotic-range proteinuria, and high FGF23 levels were significant determinants of serum 1, 25(OH)2 D levels. Conclusions Deficiency of 25OHD is prevalent in children with CKD and is associated with potentially modifiable risk factors such as milk intake, nutritional vitamin D supplement use, and proteinuria. 25OHD deficiency is a risk factor for secondary hyperparathyroidism and decreased serum 1, 25(OH)2D in children with CKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort

et al. 2015

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“…The adsorption experiments were conducted to optimize the time required for maximum adsorption of phosphate onto Fe(II)-MMT. First 200 mL of aqueous solution of phosphate containing 13.1 mg of sodium dihydrogen phosphate and 6.6 mg of ascorbic acid were mixed with 100 mg of Fe(II)-MMT powder for 10,20,30,40,70,90,140,190,240, and 290 min at 37 • C in a 250-mL conical flask with constant temperature oscillation.…”

Section: Adsorption Experimentsmentioning

confidence: 99%

A promising materials approach to combatting renal hyperphosphatemia:Fe(II)-montmorillonites

Yuan¹,

Qin²,

Qiao³

et al. 2017

Turk J Chem

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Abstract:The objective of the current effort was to determine the efficacy of Fe(II)-montmorillonite (Fe(II)-MMT)as an adjuvant for specific targeted adsorption of phosphate. Specifically, Fe(II)-MMT was studied to combat hyperphosphatemia and anemia arising from chronic renal failure. The adsorption of phosphate over time, pH, and initial concentration was studied. The systems were characterized by X-ray diffraction (XRD), Raman, and zeta potential.The experimental results demonstrated the adsorption time was set to 140 min to achieve maximum adsorption efficiency. It was thus found that the maximum adsorption was at pH 3.0. In addition, it reached equilibrium when the initial phosphate concentration was at 60 mg/L while the maximum adsorption capacity was 5.75 mg of phosphate/g of Fe(II)-MMT. On the other hand, adsorption isotherms showed that the Langmuir model was better than the Freundlich model. This means that the adsorption of the phosphate on Fe(II)-montmorillonites was monolayer adsorption, and the phosphate was successfully adsorbed either onto the surface or intercalated within interlayer volume. Live experiments supported the ability of Fe (II)-MMT to control hyperphosphatemia and treat chronic renal failure.

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“…Limitation should be considered since most studies determined albumin-bound vitamin D, although unbound (bioavailable) may be a superior marker [53]. Stein et al [54] found a deficiency in 16 and 24% of patients and a significant correlation of 25OH D, but not calcitriol, to PTH. Looking at all stages of pediatric CKD, vitamin D deficiency was found in 42.6%, and 34.4% showed vitamin D insufficiency [17].…”

Section: Diagnostic Approachmentioning

confidence: 99%