Renal osteodystrophy in children

Kemper, Markus J.; Husen, Michael van

doi:10.1097/mop.0000000000000061

Cited by 12 publications

(1 citation statement)

References 98 publications

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“…It has been well established that bone is not only a source of FGF23 but also a target of FGF23 to participate Pi homeostasis [58]. High FGF23 is associated with bone demineralization, osteoporosis, and fractures [17, 18, 49, 105]; suggesting FGF23 can act as a mineralization inhibitor by controlling Ca and Pi entrance and deposit in the bone. In general speaking, FGF23 action on bone has systemic and local modes [69, 82].…”

Section: αKlotho and Fgf23 Action On Phosphate Transport In The Kidnementioning

confidence: 99%

Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters

Shi

Moe

2018

Pflugers Arch - Eur J Physiol

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Alpha-Klotho is a member of the Klotho family consisting of two other single-pass transmembrane proteins- βKlotho and γKlotho; only αKlotho has been shown to circulate in the blood. Fibroblast growth factor (FGF)23 is a member of the FGF superfamily of 22 genes/proteins. αKlotho serves as a co-receptor with FGF receptors (FGFRs) to provide a receptacle for physiological FGF23 signaling including regulation of phosphate metabolism. The extracellular domain of transmembrane αKlotho is shed by secretases and released into blood circulation (soluble αKlotho). Soluble αKlotho has both FGF23-independent and dependent roles in phosphate homeostasis by modulating intestinal phosphate absorption, urinary phosphate excretion, and phosphate distribution into bone in concerted interaction with other calciophosphotropic hormones such as PTH, and 1,25-(OH)2D. The direct role of αKlotho and FGF23 in maintenance of phosphate homeostasis is partly mediated by modulation of type II Na+dependent phosphate cotransporters in target organs. αKlotho and FGF23 are principal phosphotropic hormones and the manipulation of the αKlotho-FGF23 axis is a novel therapeutic strategy for genetic and acquired phosphate disorders and for conditions with FGF23 excess and αKlotho deficiency such as chronic kidney disease.

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