Vitamin D status and risk of non-Hodgkin lymphoma: a meta-analysis

Lu, Demin; Chen, Jian; Jin, Jie

doi:10.1007/s10552-014-0459-2

Cited by 15 publications

(12 citation statements)

References 57 publications

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“…The positive association between higher vitamin D levels and the incidence of non‐Hodgkin lymphomas is corroborated by a recent meta‐analysis in finding no protective effect of higher vitamin D levels in relation to the risk of developing non‐Hodgkin lymphoma. Several cancers are associated with immune suppression, and non‐Hodgkin lymphomas occur more often in patients with non‐melanoma skin cancer.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark

Vojdeman

Madsen

Frederiksen

et al. 2019

Intl Journal of Cancer

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Vitamin D has been linked to cancer development in both pre‐clinical and epidemiological studies. Our study examines the association between serum levels of vitamin D and cancer incidence in the Capital Region of Denmark. Individuals who had vitamin D analyzed at The Copenhagen General Practitioners Laboratory between April 2004 and January 2010 were linked to Danish registries with end of follow‐up date at Dec 31st 2014, excluding individuals with pre‐existing cancer. Cox regression models adjusted for age in one‐year intervals, sex, month of sampling, and Charlson Comorbidity Index were applied. The study population of 217,244 individuals had a median vitamin D level of 46 nmol/L (IQR 27–67 nmol/L). Non‐melanoma skin cancer was the most frequent form of cancer, followed by breast‐, lung‐, and prostate cancers. No associations were found between increments of 10 nmol/L vitamin D and incidence of breast, colorectal, urinary, ovary or corpus uteri cancer. However, higher levels of vitamin D were associated with higher incidence of non‐melanoma (HR 1.09 [1.09–1.1]) and melanoma skin cancer (HR 1.1 [1.08–1.13]) as well as prostate (HR 1.05 [1.03–1.07]) and hematological cancers (HR 1.03 [1.01–1.06]), but with lower incidence of lung cancer (HR 0.95 [0.93–0.97]). In our study, vitamin D levels are not associated with the incidence of several major cancer types, but higher levels are significantly associated with a higher incidence of skin, prostate, and hematological cancers as well as a lower incidence of lung cancer. These results do not support an overall protective effect against cancer by vitamin D.

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Section: Discussionmentioning

confidence: 99%

Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark

Vojdeman

Madsen

Frederiksen

et al. 2019

Intl Journal of Cancer

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“…These results suggest that vitamin D deficiency or sunlight-mediated immune modulation may play a role in non-Hodgkin lymphomagenesis [64]. Although a recent meta-analysis did not confirm a protective role for vitamin D in NHL[65], there is evidence that vitamin D deficiency may adversely impact NHL treatment and/or survival. In a Norwegian population-based study investigating the relationship between 25-hydroxyvitamin D levels and risk of death in cancer patients, higher levels were associated with superior survival in 145 patients with lymphoma [66].…”

Section: Preventive and Therapeutic Implicationsmentioning

confidence: 99%

New insights into the epidemiology of non-Hodgkin lymphoma and implications for therapy

Chihara

Nastoupil

Williams

et al. 2015

Expert Review of Anticancer Therapy

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Non-Hodgkin lymphoma (NHL) comprises numerous biologically and clinically heterogeneous subtypes, with limited data examining risk factors for these distinct disease entities. Many limitations exist when studying lymphoma epidemiology, therefore until recently little was known regarding the etiology of NHL subtypes. This review highlights the results of recent pooled analyses examining risk factors for NHL subtypes. We outline heterogeneity and commonality among risk factors for NHL subtypes, with proposed subtype-specific as well as shared etiologic mechanisms. In addition, we describe how the study of lymphoma epidemiology may translate into prevention or therapeutic targeting as we continue to explore the complexities of lifestyle and genetic factors that impact lymphomagenesis.

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“…Diets high in trans-fatty acids, processed meats, and higher fat dairy products were positively associated with NHL risk; whereas diets high in n3 fatty acids and total seafood were inversely associated with risk (4). In a meta-analyses conducted from 9 studies (8 case-control and 1 cohort), it was reported that higher vitamin D status does not play a protective role in risk of NHL or common NHL subtypes (6). Several studies have also shown diet to be associated with inflammation(11, 12).…”

Section: Discussionmentioning

confidence: 99%

“…Infections with HIV, hepatitis B (HBV) and C (HCV) viruses, Epstein-Barr virus (EBV), human herpes virus 8, and perhaps Helicobacter pylori are among the few established risk factors for specific NHL histological subtypes (3). There also is growing evidence indicating a possible role of diet in the development of NHL (4–6). Increased trans-fatty acid intake was associated with increased risk, whereas increased omega-3 fatty acid intake was associated with decreased NHL risk (4).…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index and non-Hodgkin lymphoma risk in an Italian case–control study

Shivappa

Hébert

Taborelli

et al. 2017

Cancer Causes Control

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Background While dietary factors have been shown to play an important etiologic role in non-Hodgkin lymphoma (NHL), little is known about the association between inflammatory properties of diet and NHL risk. Methods We explored the association between the dietary inflammatory index (DII) and NHL risk in a multicentric Italian case-control study conducted between 1999 and 2014. Cases were 536 subjects with incident, histologically confirmed NHL from 3 areas in Italy. Controls were 984 subjects admitted to the same network of hospitals as the cases for acute, non-malignant conditions, unrelated to diet. DII scores were computed based on 30 nutrients and food items assessed using a reproducible and validated 78-item food frequency questionnaire. Odds ratios (ORs) were estimated through logistic regression models adjusting for age, total energy intake and other recognised or likely confounding factors. Results Subjects in the highest quartile of DII scores (i.e., with the most pro-inflammatory diets) had a higher risk of NHL compared to subjects in the lowest quartile (i.e., with the most anti-inflammatory diets) (ORQuartile4vs1= 1.61, 95% confidence interval, CI, 1.07, 2.43; p-trend=0.01). Stratified analyses produced stronger associations between DII and NHL among males (ORQuartile4vs1= 2.14; 95%CI=1.25, 3.67) with significant heterogeneity (p-value=0.02); when analysed by histological subtype, a significant association was observed with diffuse large B-cell lymphoma (ORQuartile4vs1= 1.84; 95%CI=1.09, 3.10). Conclusion A pro-inflammatory diet, as indicated by higher DII scores, is associated with elevated odds of NHL, especially among males.

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Vitamin D status and risk of non-Hodgkin lymphoma: a meta-analysis

Abstract: Higher vitamin D status does not play a protective role in risk of NHL or common NHL subtypes.

Cited by 15 publications

References 57 publications

Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark

Vitamin D levels and cancer incidence in 217,244 individuals from primary health care in Denmark

New insights into the epidemiology of non-Hodgkin lymphoma and implications for therapy

Dietary inflammatory index and non-Hodgkin lymphoma risk in an Italian case–control study

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