Vitamin D status and asthma, lung function, and hospitalization among British adults

Zhu, Yiqun; Jing, Danrong; Liang, Huaying; Li, Dianwu; Chang, Qinyu; Shen, Minxue; Pan, Pinhua; Liu, Hong; Zhang, Yan

doi:10.3389/fnut.2022.954768

Cited by 15 publications

(14 citation statements)

References 44 publications

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“…These differences were likely due to the characteristics of the study populations or might be regional. Our recent cross-sectional study based on a large population not only verified the linkage between optimal vitamin D (>50 nmol/L) and decreased prevalence of asthma but also discovered that vitamin D deficiency (< 25 nmol/L) was associated with poor asthma control ( 29 ). However, due to the limitation of the cross-sectional study, this large prospective cohort study based on the UK Biobank was conducted to further support the protective role of vitamin D and reduced risk of adult-onset asthma.…”

Section: Discussionmentioning

confidence: 68%

Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study

et al. 2023

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IntroductionVitamin D has been known to be associated with asthma, particularly in children, while the evidence among adults is limited and inconclusive. This study aimed to investigate the association between serum, vitamin D concentrations, and the incidence of adult-onset asthma and also the modified effect caused by sleep patterns and genetic risks.MethodsA prospective cohort study with 307,872 participants aged between 37 and 73 years was conducted based on the UK Biobank, with a median follow-up of 12 years. The Cox proportional hazard model was applied to evaluate the association between vitamin D status and incident adult-onset asthma, and the modified effect was investigated by conducting stratified analysis according to sleep pattern score and genetic risk score, and subgroup analyses were performed by sex, age, BMI, and smoking status as well.ResultsIndividuals with optimal vitamin D concentration were associated with 11.1% reduced risk of incident asthma compared to those participants with deficient vitamin D (HR = 0.889; 95% CI: 0.820–0.964; p = 0.005). Moreover, stratification analysis demonstrated that the protective effect of vitamin D on asthma risk was modified by sleep patterns or genetic susceptibility, with the strongest protective effect being observed in the subpopulation with a moderate sleep pattern (HR = 0.883; 95% CI: 0.797–0.977; p = 0.016) and a moderate genetic risk (HR = 0.817; 95% CI: 0.711–0.938; p = 0.004). In subgroup analyses, the protective effect of optimal vitamin D levels was only significant among men, individuals younger than 60 years of age, overweight individuals, and current or previous smokers.ConclusionIncreased serum vitamin D levels were associated with a lower risk of incident adult-onset asthma, and this association was modified by sleep patterns and genetic predisposition to some extent.

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Section: Discussionmentioning

confidence: 68%

Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study

et al. 2023

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“…However, the relationship between 25(OH)Vit.D and asthma hospitalization was not significant. [ 70 ]…”

Section: Discussionmentioning

confidence: 99%

Association between 25-hydroxy vitamin D and lung function (FEV1, FVC, FEV1/FVC) in children and adults with asthma: A systematic review

Abi-Ayad,

Nedjar,

Chabni

2023

Lung India

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Asthma is a chronic respiratory disease that poses significant individual, social, financial and healthcare burdens. Physicians and researchers have recommended 25-hydroxy vitamin D supplementation, in combination with prescribed medication, as a potential means of reducing asthma severity. This systematic review focuses on the association between 25-hydroxy vitamin D levels and lung function in both children and adults with asthma. We identified published work by searching MEDLINE via PubMed, using regular search terms related to 25-hydroxy vitamin D and asthma. Fourteen studies were screened out of 643 eligible citations from MEDLINE research that involved 65 children and 951 adults. A strong positive association was observed in four studies, whereas five showed a moderate association, and two had no correlation. The majority of studies found a negative correlation between 25-hydroxy vitamin D deficiency and mild, uncontrolled and partly controlled asthma. 25-hydroxy vitamin D 25 OH values were below 20 ng/ml in the majority of studies, and those with uncontrolled severe asthma showed the lowest values.

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“…On the other hand, asthmatics could also be influenced by a wide variety of factors, including age [ 35 , 36 ], sex [ 37 ], BMI [ 38 , 39 ], and smoking status [ 40 ]. In addition to the factors previously discussed, educational background and Townsend deprivation index are socioeconomic factors that exert effects on environmental allergen exposure [ 41 , 42 ] and may lead to variations in coffee and tea consumption [ 43 , 44 ]. Similar to other studies [ 7 , 25 , 45 ], we adjusted for education and Townsend deprivation index in this study.…”

Section: Discussionmentioning

confidence: 99%

Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank

et al. 2022

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Background: Previous observational studies investigated the relationship between coffee and tea intake and the risk of asthma, however, the conclusions were inconsistent. Further, the combined effect of coffee and tea consumption on asthma has rarely been studied. Methods: We examined associations between the self-reported intake of tea and coffee and the risk of incident asthma in a total of 424,725 participants aged from 39 to 73 years old from the UK Biobank. Cox proportional hazards models were used to estimate the associations between coffee/tea consumption and incident adult-onset asthma, adjusting for age, sex, race, smoking status, body mass index (BMI), education, and Townsend deprivation index. Results: Cox models with penalized splines showed J-shaped associations of coffee, tea, caffeinated coffee, and caffeine intake from coffee and tea with the risk of adult-onset asthma (p for nonlinear <0.01). Coffee intake of 2 to 3 cups/d (hazard ratio [HR] 0.877, 95% confidence interval [CI] 0.826–0.931) or tea intake of 0.5 to 1 cups/d (HR 0.889, 95% CI 0.816–0.968) or caffeinated coffee intake of 2 to 3 cups/d (HR 0.858, 95% CI 0.806–0.915) or combination caffeine intake from tea and coffee of 160.0 to 235.0 mg per day (HR 0.899, 95% CI 0.842–0.961) were linked with the lowest hazard ratio of incident asthma after adjustment for age, sex, race, smoking status, BMI, qualification, and Townsend deprivation index. Conclusions: Collectively, the study showed light-to-moderate coffee and tea consumption was associated with a reduced risk of adult-onset asthma and controlling total caffeine intake from coffee and tea for a moderate caffeine dose of 160.0 to 305.0 mg/day may be protective against adult-onset asthma. Further investigation on the possible preventive role of caffeine in asthma is warranted.

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Vitamin D status and asthma, lung function, and hospitalization among British adults

Cited by 15 publications

References 44 publications

Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study

Vitamin D status, sleep patterns, genetic susceptibility, and the risk of incident adult-onset asthma: a large prospective cohort study

Association between 25-hydroxy vitamin D and lung function (FEV1, FVC, FEV1/FVC) in children and adults with asthma: A systematic review

Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank

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