Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank

Lin, Fengyu; Zhu, Yiqun; Liang, Huaying; Li, Dianwu; Jing, Danrong; Liu, Hong; Pan, Pinhua; Zhang, Yan

doi:10.3390/nu14194039

Cited by 9 publications

(5 citation statements)

References 46 publications

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“…A study from South Korea found coffee intake had a protective effect on asthma (44). A prospective cohort study from the UK Biobank has found that coffee and tea intake may be protective against asthma (45). This study found coffee and tea intake were not associated with asthma.…”

Section: Discussionmentioning

confidence: 55%

Dietary factors and risk for asthma: A Mendelian randomization analysis

Yang

et al. 2023

Front. Immunol.

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BackgroundPrevious research has found a link between dietary factors and asthma. However, few studies have analyzed the relationship between dietary factors and asthma using Mendelian randomization. Methods: The IEU Open GWAS project (https://gwas.mrcieu.ac.uk/) was the source of exposure and outcome datasets. The exposure datasets included Alcoholic drinks per week, Alcohol intake frequency, Processed meat intake, Poultry intake, Beef intake, Non-oily fish intake, Oily fish intake, Pork intake, Lamb/mutton intake, Bread intake, Cheese intake, Cooked vegetable intake, Tea intake, Fresh fruit intake, Cereal intake, Salad/raw vegetable intake, Coffee intake, and Dried fruit intake. The weighted median, MR-Egger, and Inverse Variance Weighted methods were used as the main methods of Mendelian randomization analysis. Heterogeneity and pleiotropic analysis were performed to ensure the accuracy of the results.ResultsAlcohol intake frequency (after removing outliers OR: 1.217; 95% CI: 1.048-1.413; p=0.00993) was related to an increased risk of Asthma. Fresh fruit intake (OR: 0.489; 95% CI: 0.320-0.748; p=0.000954) and Dried fruit intake (after removing outliers OR: 0.482; 95% CI: 0.325-0.717; p= 0.000312) were discovered as protective factors. Other dietary intakes found no causal relationship with asthma.ConclusionThis study found that dried fruit intake and fresh fruit intake were associated with a reduced risk of asthma, and alcohol intake frequency was associated with an increased risk of asthma. This study also found that other factors included in this study were not associated with asthma.

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Section: Discussionmentioning

confidence: 55%

Dietary factors and risk for asthma: A Mendelian randomization analysis

Yang

et al. 2023

Front. Immunol.

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“…Fourth, we relaxed the p -value threshold ( p < 5 × 10 −6 ) of SNPs due to lack of sufficient SNPs (less than three) after linkage disequilibrium, resulting in the reduced robustness of MR results. Fifth, in the observational analyses, although exhaustive adjustment was conducted in the multivariable analyses, residuals or unmeasured confounders could not be excluded [ 49 , 50 , 51 ]. Finally, our analyses were limited to individuals of European ancestry.…”

Section: Discussionmentioning

confidence: 99%

Instant Coffee Is Negatively Associated with Telomere Length: Finding from Observational and Mendelian Randomization Analyses of UK Biobank

Wei

Lai

et al. 2023

Nutrients

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Telomere length, as a biomarker of accelerated aging, is closely related to many chronic diseases. We aimed to explore the association between coffee consumption and telomere length. Our study included 468,924 participants from the UK Biobank. Multivariate linear models (observational analyses) were conducted to evaluate the associations of coffee intake, instant coffee intake, and filtered coffee intake with telomere length. In addition, we evaluated the causality of these associations in Mendelian randomization (MR) analyses by four methods (inverse-variance weighted (IVW), MR pleiotropy residual sum and outlier (MR-PRESSO), MR-Egger, and weighted median). Observational analyses indicated that coffee intake and instant coffee intake were negatively correlated with telomere length, which was equal to 0.12 year of age-related decrease in telomere length for each additional cup of coffee intake (p < 0.001), and 0.38 year of age-related decrease in telomere length for each additional cup of instant coffee intake (p < 0.001), respectively. There was no significant correlation between filtered coffee and telomere length (p = 0.862). Mendelian randomization analyses supported the results of observational analyses. Coffee intake was found to have a causal effect on telomere length through weighted median analysis (p = 0.022), and instant coffee intake had a causal effect on telomere length through IVW analysis (p = 0.019) and MR-PRESSO analysis (p = 0.028). No causal relationship was found between filtered coffee intake and telomere length (p > 0.05). Coffee intake, particularly instant coffee, was found to have an important role in shortening telomere length.

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“…Gallocatechin has antioxidant functions and protective effects against diseases such as cancer and heart disease ( Someya et al, 2002 ). Caffeine relaxes smooth muscle of the bronchi, making it of value for the treatment of asthma and the bronchospasm of chronic bronchitis ( Lin et al, 2022 ). In addition, the various metabolites were predominantly enriched in metabolic pathways, secondary metabolite production, ABC transporters, D-amino acid metabolism, and other material metabolic activities after the inoculation with the “golden flower” fungi.…”

Section: Discussionmentioning

confidence: 99%

Metabolic improvements of novel microbial fermentation on black tea by Eurotium cristatum

Wang,

Shan,

et al. 2023

Front. Microbiol.

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Due to its traditional fermentation, there are obvious limits on the quality improvements in black tea. However, microbial fermentation can provide an abundance of metabolites and improve the flavor of tea. The “golden flower” fungi are widely used in the microbial fermentation of tea and has unique uses in healthcare. To further explore the improvements in black tea quality achieved via microbial fermentation, we used widely targeted metabolomics and metagenomics analyses to investigate the changes in and effects of metabolites and other microorganisms during the interaction between the “golden flower” fungi and black tea. Five key flavor metabolites were detected, the levels of catechin, epigallocatechin gallate, (−)-epicatechin gallate were decreased by different degrees after the inoculation of the “golden flower” fungus, whereas the levels of caffeine and (+)-gallocatechin increased. Botryosphaeriaceae, Botryosphaeriales, Dothideomycetes, Aspergillaceae, Trichocomaceae, and Lecanoromycetes play a positive role in the black tea fermentation process after inoculation with the “golden flower” fungi. D-Ribose can prevent hypoxia-induced apoptosis in cardiac cells, and it shows a strong correlation with Botryosphaeriaceae and Botryosphaeriales. The interaction between microorganisms and metabolites is manifested in tryptophan metabolism, starch and sucrose metabolism, and amino sugar and nucleotide sugar metabolism. In conclusion, the changes in metabolites observed during the fermentation of black tea by “golden flower” fungi are beneficial to human health. This conclusion extends the knowledge of the interaction between the “golden flower” fungi and black tea, and it provides important information for improving the quality of black tea.

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Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank

Cited by 9 publications

References 46 publications

Dietary factors and risk for asthma: A Mendelian randomization analysis

Dietary factors and risk for asthma: A Mendelian randomization analysis

Instant Coffee Is Negatively Associated with Telomere Length: Finding from Observational and Mendelian Randomization Analyses of UK Biobank

Metabolic improvements of novel microbial fermentation on black tea by Eurotium cristatum

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