Dietary factors and risk for asthma: A Mendelian randomization analysis

Yang, Wenwen; Yang, Yanjiang; He, Li; Zhang, Min; Sun, Shuhui; Wang, Rui; Han, Baohui

doi:10.3389/fimmu.2023.1126457

Cited by 24 publications

(15 citation statements)

References 47 publications

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“…The intake of vitamins has also been found to affect IPF in clinical trials [ 11 ]. Dietary intake has been shown to have a causal relationship with asthma [ 12 ] and lung cancer [ 13 ]. The research on the causal relationship between dietary intake and IPF still needs to be improved, and the specific nutritional information related to IPF has yet to be identified.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Dietary intake and incidence risk of idiopathic pulmonary fibrosis: a Mendelian randomization study

Zhang,

Gan,

Zhang

2023

BMC Pulm Med

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Background Dietary intake has been shown to have a causal relationship with various lung diseases, such as lung cancer and asthma. However, the causal relationship between dietary intake and idiopathic pulmonary fibrosis (IPF) remains unclear. We conducted a two-sample Mendelian Randomization (MR) study to investigate the causal relationship between dietary intake and IPF. Methods The exposure datasets included meat, fruit, vegetable, and beverage intake from the UK Biobank. IPF data came from the EBI database of 451,025 individuals. All data in this study were obtained from the IEU Open GWAS Project. The inverse variance weighted (IVW), MR-Egger, and weighted median methods were used as the primary methods. Sensitivity analyses were performed to ensure the validity of the results. Results Oily fish intake [odds ratio (OR):0.995; 95% confidence interval (CI): 0.993–0.998; p = 6.458E-05] and Dried fruit intake (OR:0.995;95%CI:0.991–0.998; p = 0.001) were discovered as protective factors. There was also a suggestive correlation between Beef intake (OR:1.006;95%Cl:1.001–1.012; p = 0.023) and IPF. Sensitivity analysis did not reveal any contradictory results. No causal relationship was found between IPF and the rest of the dietary exposures. Conclusions Our study found that Oily fish and Dried fruit intake were associated with the risk of IPF, while Beef intake was suggestively associated with the risk of IPF. Other studies are still needed to confirm the results in the future.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Dietary intake and incidence risk of idiopathic pulmonary fibrosis: a Mendelian randomization study

Zhang,

Gan,

Zhang

2023

BMC Pulm Med

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“…Therefore, more research evidence is needed to justify this in the future. Similar to the results of previous MR analyses, our study also demonstrated that the intake of dried fruits can slow down the onset of asthma to a certain extent 48 . Unfortunately, through MR analysis, we did not find an exact dietary factor associated with the onset of OSA, and only explored some factors that may influence it.…”

Section: Discussionsupporting

confidence: 91%

Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Lai,

Li,

Peng

et al. 2023

Sci Rep

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The existence of causal relationship between dietary factors and respiratory diseases is uncertain. We comprehensively investigated the association between dietary factors and respiratory diseases by using Mendelian randomization (MR). Genetic variants linked to dietary factors were selected as instrumental variables with genome-wide significance. These instrumental variables were obtained from large GWAS databases. These databases include Biobank, the FinnGen study, and other large consortia. We used multivariate MR analyses to control the effects of smoking and education. Median analysis was conducted to evaluate whether body mass index (BMI) played a role in dietary factors in respiratory diseases. Dried fruit intake was found to be associated with a decreased risk of chronic obstructive pulmonary disease (COPD) (OR: 0.211; 95% CI 0.117–0.378; P < 0.001) and asthma (OR: 0.539; 95% CI 0.357–0.815; P = 0.003). Conversely, pork intake was associated with an increased risk of international pharmaceutical federation (IPF) (OR: 1.051*102, 95% CI 4.354–2.56*103, P = 0.004). However, no significant associations were observed between the 20 dietary factors and obstructive sleep apnea (OSA). In addition, multivariate MR analyses showed that the above results were unchanged in smoking and nonsmoking populations, while the effect of dried fruit intake on asthma was significantly attenuated after corrective education. The results of the mediator variable analysis indicated that BMI could serve as a mediator of the above results. This study found that dried fruits slowed the progression of COPD and asthma, while pork promoted IPF. However, no effect of dietary factors on OSA was found. Meanwhile, we showed that the above results were unchanged in smoking and non-smoking populations. In contrast, education could influence the role of diet on asthma, and BMI could be used as a mediating variable to influence the above results.

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“…The project, supported by the MRC Integrated Epidemiology Unit (IEU) at the University of Bristol, collates and analyses GWAS data from UK Biobank, published articles. This study was exempt from ethical review body approval as the data used in this study are open, anonymized and de-identi ed [14].…”

Section: Methodsmentioning

confidence: 99%

Exploring the Impact of Dietary Factors on Intracranial Aneurysm Risk: Insights from Mendelian Randomization Analysis

Ma,

Zong,

Wang

et al. 2024

Preprint

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Background: While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, the application of Mendelian randomization to explore this association remains largely uncharted. Methods: n our study, we analyzed a wide array of dietary factors using data from the IEU Open GWAS project, which included meat varieties (oily fish, pork, lamb/mutton, beef and poultry), vegetarian foods (both cooked and raw vegetables, along with fresh and dried fruits), cereal and the frequency of alcohol intake. We included pooled intracranial aneurysm GWAS data from a comprehensive dataset of 7,495 cases as well as 71,934 controls. In MR analysis, we employed multiple Mendelian randomization techniques such as weighted median, MR-Egger, and Inverse Variance Weighted methods and rigorously controlled the false discovery rates through the Bonferroni correction across ten dietary exposures. The study's robustness was further ensured by assessing heterogeneity and pleiotropy using Cochran's Q test and MR-Egger method, supplemented by leave-one-out and MR-PRESSO analyses, thus solidifying the validity of our findings. Results: Our analysis identified a significant association between cooked vegetables (OR: 2.296; 95% CI: 0.726 ~ 3.867; p = 0.0042) and an elevated risk of intracranial aneurysms. Besides, the initial analysis suggested a statistically significant association between the dried fruit (OR: 0.385; 95%CI: -1.842 ~ -0.067; p= 0.0350), frequency of alcohol intake (OR: 1.419; 95% CI: 0.039 ~ 0.661; p = 0.0276) and the risk of intracranial aneurysms. However, this significance was not sustained after applying the Bonferroni correction for multiple testing, indicating a need for cautious interpretation despite the initially promising findings. No causal links were found between intracranial aneurysms and other dietary intakes investigated in this study. Conclusion: This study identified a clear causal link between cooked vegetable intake and an increased risk of intracranial aneurysm, while suggesting a potential connection between the frequency of alcohol intake and the elevated risk, although this association did not reach statistical significance after multiple testing corrections. Conversely, no significant associations were observed between the risk of intracranial aneurysm and the consumption of various meats, cheese, and other fruits and vegetables.

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Dietary factors and risk for asthma: A Mendelian randomization analysis

Cited by 24 publications

References 47 publications

RETRACTED ARTICLE: Dietary intake and incidence risk of idiopathic pulmonary fibrosis: a Mendelian randomization study

RETRACTED ARTICLE: Dietary intake and incidence risk of idiopathic pulmonary fibrosis: a Mendelian randomization study

Mendelian randomization study reveals the relationship between dietary factors and respiratory diseases

Exploring the Impact of Dietary Factors on Intracranial Aneurysm Risk: Insights from Mendelian Randomization Analysis

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