Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh

DE, Roth; Shah, Rashed; Re, Black; Ah, Baqui

doi:10.1111/j.1651-2227.2009.01594.x

Cited by 158 publications

(159 citation statements)

References 24 publications

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“…25 (OH) D was found to be lower in babies with LRTI and it was concluded that vitamin D deficiency was related with LRTI in the early childhood (16). In our study, no significant difference was found between the patient and control groups in terms of vitamin D level.…”

Section: Discussioncontrasting

confidence: 43%

The effect of vitamin D on lower respiratory tract infections in children

Şişmanlar¹,

Aslan²,

Gülbahar³

et al. 2016

Turk Pediatri Ars

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Aim: Lower respiratory tract infections including mainly pneumonia represent an important public health problem leading to high mortality and mobidity rates in children aged below five years in developing countries including our country. Vitamin D deficiency has been associated with increased risk of rickets/osteomalacia, various cancers, autoimmune diseases, hyperproliferative skin diseases, cardiovascular system diseases and infectious diseases. Vitamin D has an important role in cellular and humoral immunity and pulmonary functions. Vitamin D deficiency and lower respiratory tract infection are common health problems in children in our country and no clinical study investigating the relationship between these problems has been conducted so far. In this case-control study, we aimed to assess the association between vitamin D level and lower respiratory tract infection in children. Material and Methods: Sixty-three children aged between six months and five years with lower respiratory infections and 59 age-matched children who had no history of respiratory symptoms in the last month and no accompanying chronic disease were compared in terms of vitamin D levels. The children in the patient group were also evaluated by the clinical picture. Results: No significant correlation was found between vitamin D levels and lower respiratory tract infection in terms of disease and its severity. However, it was found that vitamin D deficiency/ insufficiency was observed with a high rate in all children included in the study. Conclusions: Although no correlation was found between vitamin D level and lower respiratory tract infection, it is recommended that vitamin D level should be measured in children with lower respiratory tract infection and vitamin D supplementation should be given to all children especially in winter months based on the fact that the level of vitamin D was lower than normal in approximately half of the children included in the study and considering the effects of vitamin D on infections, pulmonary functions and immunity. (Turk Pediatri Ars 2016; 51: 94-9)

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Section: Discussioncontrasting

confidence: 43%

The effect of vitamin D on lower respiratory tract infections in children

Şişmanlar¹,

Aslan²,

Gülbahar³

et al. 2016

Turk Pediatri Ars

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“…Using the cut-off concentration of 50 nmol/l, Wayse et al reported vitamin D deficiency among 61 % of Indian children under 5 years of age (17) . Roth et al found a mean s-25(OH)D concentration of 39·2 nmol/l among Bangladeshi children aged 1-23 months (18) . Similarly high prevalence of vitamin D deficiency was identified among pregnant women and their newborns, adolescents and adults in the region (19)(20)(21)(22)(23) .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status in pre-school children in rural Nepal

Avagyan

Gundersen²,

Madar³

2015

Public Health Nutr.

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Objective: Vitamin D plays a major role in Ca and bone metabolism, and its extraskeletal functions are being appraised. Although inadequate vitamin D concentrations have been reported in populations worldwide, too little is known about vitamin D status and its determinants among children in developing countries. We aimed to determine vitamin D status and its determinants in Nepalese children of pre-school age. Design: A community-based, cross-sectional study. Setting: Rural Nepal at latitude 27·39°N. Subjects: Healthy children (n 280) aged 12-60 months, selected randomly from the records of a vitamin A supplementation programme. Blood samples were collected using the dried blood spot technique and analysed for serum 25-hydroxyvitamin D (s-25(OH)D) concentration using liquid chromatographytandem mass spectrometry. Ca intake and background variables were assessed with a structured questionnaire. Results: Hypovitaminosis D, defined as s-25(OH)D concentration less than 50 nmol/l, was found in 91·1 % of the children. S-25(OH)D concentration was not related to gender, socio-economic indicators, sun exposure or nutritional status. Currently breast-fed children had higher s-25(OH)D concentrations (36·4 (SD 13·2) nmol/l) than those who were not (28·6 (SD 9·8) nmol/l, P < 0·001). Adjustment for sociodemographic factors did not alter the results. Conclusion: There is widespread vitamin D deficiency among pre-school children in a rural area of Nepal. In our sample, sociodemographic factors did not affect the vitamin D status of children, but prolonged breast-feeding was associated with higher s-25(OH)D concentrations. Further research is required to investigate the health consequences of poor vitamin D status for this population. Low levels of vitamin D are reported in diverse populations around the world (1-3) , with one review suggesting that as many as 14 % of the world's population have levels inadequate for general well-being (4) . Serum concentration of 25-hydroxyvitamin D (s-25(OH)D) is the standard assessment for vitamin D status in the body and s-25(OH)D concentration of 50 nmol/l or more is considered sufficient for optimal bone-related health outcomes by the Institute of Medicine (5) . Studies from Turkey, the Middle East and India have revealed that up to 50 % of children have vitamin D deficiency (6) . A number of determinants that affect s-25(OH)D concentration in children have been identified and include skin pigmentation, prolonged breast-feeding without vitamin D supplementation and low consumption of foods rich in vitamin D (7) . However, little is known about the vitamin D status of Nepalese children.Nepal is a predominantly Hindu nation bordering Tibet and India, located between the latitudes of 26°N and 31°N. Nepalese cultural values do not restrict sun exposure and about 300 d per year are sunny (8) . A few studies that have investigated vitamin D status in special groups in Nepal, such as pregnant women and alcohol-abusing populations, report a wide range of vitamin D deficiency prevalence rat...

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“…Reports are inconsistent on the role of vitamin D in lower respiratory tract infections (4,5). Some believe that such a deficiency increases the risk of lower respiratory infections (4), while others disagree (5).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum 25-Hydroxy Vitamin D Levels in Children with Acute Bronchiolitis

Mahyar

Ayazi

Abbasi

et al. 2016

Arch Pediatr Infect Dis

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Background: According to some reports, 25-hydroxy vitamin D (25 (OH) D) deficiency leads to respiratory diseases. Given the high prevalence of acute bronchiolitis in young infants, the assessment of 25 (OH) D status is very important for this disease. Objectives: This study was conducted to determine the relationship between the serum levels of 25 (OH) D and acute bronchiolitis in young infants. Methods: In the present study, 57 patients with acute bronchiolitis (case control) were compared with 57 healthy children (control group) in terms of 25 (OH) D serum levels. The serum levels of 25 (OH) D were measured using the ELISA method. The results were analyzed and compared between the two groups.

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Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh

Abstract: Vitamin D status was associated with early childhood ALRI in a matched case-control study in rural Bangladesh. Randomized trials may establish whether interventions to improve vitamin D status can reduce the burden of ALRI in early childhood.

Cited by 158 publications

References 24 publications

The effect of vitamin D on lower respiratory tract infections in children

The effect of vitamin D on lower respiratory tract infections in children

Vitamin D status in pre-school children in rural Nepal

Evaluation of Serum 25-Hydroxy Vitamin D Levels in Children with Acute Bronchiolitis

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