Vitamin D status and abdominal aortic calcification in postmenopausal women

Maghraoui, A. El; Toufik, Hamza; Sadni, Siham; Maataoui, Aissam El; Majjad, A.; Rezqi, Asmaa; Ouzzif, Z.; Mounach, Aziza

doi:10.1007/s00774-017-0832-9

Cited by 9 publications

(8 citation statements)

References 47 publications

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“…The prevalence of AAC and extended AAC was low for the same reason, and most likely explains the lack of any significant association seen in the present study. In comparison, a recent study of 429 Caucasian women (mean age 60 years) living in the Rabat area of Morocco had an extended AAC (AAC24 ≥ 5) prevalence of 7.9% [60].…”

Section: Discussionmentioning

confidence: 89%

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

et al. 2020

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Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group.

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Section: Discussionmentioning

confidence: 89%

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

et al. 2020

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“…The abovementioned studies on the correlation between vitamin D and calcification are consistent with the results of this study. However, El Maghraoui et al proposed that there is an independent association between extended aortic calcifications and vertebral fractures in postmenopausal women, but not with serum vitamin D levels [ 27 ]. Therefore, it is important to explore further the association between serum 25(OH)D levels and AAC.…”

Section: Discussionmentioning

confidence: 99%

Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study

Liu

Zuo

Wang

et al. 2023

International Journal of Clinical Practice

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In the American population, the relationship between the standardized serum 25-hydroxyvitamin D (25(OH)D) concentration and the risk of abdominal aortic calcification (AAC) is unclear. The purpose of our study was to investigate the relationship between serum 25(OH)D concentration and AAC risk. Participants from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2014 were analyzed cross sectionally. An analysis of the relationship between serum 25(OH)D concentration and incident AAC and severe AAC (SAAC) was based on the restricted cubic spline (RCS) and multivariable logistic regression model. In addition, generalized additive models with smooth functions were used to evaluate the relationship between serum 25(OH)D concentration and the degree of AAC. Finally, a subgroup analysis was conducted. There were a total of 3,040 individuals in our study. The serum 25(OH)D concentration was divided into quartiles (Q1: 9.37–50.5 nmol/L; Q2: 50.6–67.2 nmol/L; Q3: 67.3–85.8 nmol/L; and Q4: 85.9–318.0 nmol/L); the lowest quartile served as the reference group (Q1). After adjusting for known confounding variables, compared with the lowest quartile (Q1) of serum 25(OH)D concentration, the odds ratios with 95% confidence intervals for AAC and SAAC across the quartiles (Q2, Q3, and Q4) were (1.042 (0.812, 1.338), 0.863 (0.668, 1.115), and 1.022 (0.787, 1.327)) and (1.48 (0.87, 2.52), 1.70 (1.01, 2.92), and 2.13 (1.19, 3.86)), respectively. As shown by the RCS plot, the serum 25(OH)D concentration was associated with the risk of AAC/SAAC in a U-shaped pattern ( P for nonlinearity <0.05). In addition, the degree of AAC decreased at first and then increased as the serum 25(OH)D concentration increased. In conclusion, a U-shaped relationship existed between serum 25(OH)D concentration and the risk of AAC and SAAC. Consequently, the risk of AAC and SAAC may be mitigated with regular monitoring and vitamin D supplementation.

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“…More specifically, in postmenopausal women, the aggravation in AAC score is linked to the increase in bone resorption in particular when BMD is inversely linked to AAC score [5,12,13]. The connection of AAC with poor bone status, higher risk of fracture and bone loss has been consistently reported in cohorts after adjustment for numerous shared risk factors, mainly age, lifestyle, co-morbidity, hormones, vitamin D status and medications that influence both pathologies [53]. For example, severe AACs are linked to a greater prevalence of vertebral fracture after adjustment for age and BMI, and a greater number of vertebral fractures has been shown in older men, after adjustment for BMD and other variables [15].…”

Section: Discussionmentioning

confidence: 99%

Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture

et al. 2019

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Context MicroRNA (miRNA) regulate post-transcriptionally the expression of osteogenesis and angiogenesis associated genes and emerge as potential non-invasive biomarkers in vascular and bone diseases. Severe abdominal aortic calcification (AAC) is associated with higher risk of cardiovascular event and of fragility fracture. Objective To identify miRNA linked to the aggravation of AAC and to incident osteoporotic fracture. Design Postmenopausal women (>50 years) with available serum at inclusion and data for each outcome (Kauppila score and incident fracture) were selected from the OFELY prospective cohort. We conducted a case-control study in 434 age-matched women, 50% with incident osteoporotic fracture over 20 years of follow-up and a second study in 183 women to explore AAC over 17 years. Methods Serum expression of three miRNA involved in vascular calcification and bone turnover regulation (miRs-26a-5p,-34a-5p, and -223-5p) was quantified at baseline by TaqMan Advanced miRNA technology and expressed by relative quantification. Outcomes were the association of miRNA levels with (1) incident osteoporotic fractures during 20 years, (2) AAC aggravation during 17 years. Results MiRNA level was not associated with incident fractures (miR-26a-5p: 1.06 vs 0.99, p = 0.07; miR-34a-5p: 1.15 vs 1.26, p = 0.35; miR-223a-5p: 1.01 vs 1.05, p = 0.32). 93 women had an increase in Kauppila score over 17 years while 90 did not. None of the miRNAs was associated with an aggravation in AAC (miR-26a-5p: 1.09 vs 1.10, p = 0.95; miR-34a-5p: 0.78 vs 0.73, p = 0.90; miR-223-5p: 0.97 vs 0.78, p = 0.11). Conclusions Circulating miR-26a-5p, -34a-5p and -223-5p are not significantly associated with incident fracture and AAC aggravation.

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Vitamin D status and abdominal aortic calcification in postmenopausal women

Cited by 9 publications

References 47 publications

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study

Selected serum microRNA, abdominal aortic calcification and risk of osteoporotic fracture

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