Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Brahmbhatt, Saloni; Mikhail, Mageda; Islam, Shahidul; Aloia, John F.

doi:10.3390/nu12030861

Cited by 8 publications

(8 citation statements)

References 58 publications

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“…When the serum vitamin D level is at the right concentration, it can inhibit the abovementioned process and slow the progression of AAC. However, Brahmbhatt et al did not find an association between baseline 25(OH)D and AAC in older black women; serum 25(OH)D levels above 75 nmol/L did not affect the progression of AAC [ 30 ]. In addition, de Boer et al revealed that lower 25(OH)D concentrations were associated with an increased risk of coronary artery calcification (CAC) in a large, community-based, multiethnic population [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study

Liu

Zuo

Wang

et al. 2023

International Journal of Clinical Practice

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In the American population, the relationship between the standardized serum 25-hydroxyvitamin D (25(OH)D) concentration and the risk of abdominal aortic calcification (AAC) is unclear. The purpose of our study was to investigate the relationship between serum 25(OH)D concentration and AAC risk. Participants from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2014 were analyzed cross sectionally. An analysis of the relationship between serum 25(OH)D concentration and incident AAC and severe AAC (SAAC) was based on the restricted cubic spline (RCS) and multivariable logistic regression model. In addition, generalized additive models with smooth functions were used to evaluate the relationship between serum 25(OH)D concentration and the degree of AAC. Finally, a subgroup analysis was conducted. There were a total of 3,040 individuals in our study. The serum 25(OH)D concentration was divided into quartiles (Q1: 9.37–50.5 nmol/L; Q2: 50.6–67.2 nmol/L; Q3: 67.3–85.8 nmol/L; and Q4: 85.9–318.0 nmol/L); the lowest quartile served as the reference group (Q1). After adjusting for known confounding variables, compared with the lowest quartile (Q1) of serum 25(OH)D concentration, the odds ratios with 95% confidence intervals for AAC and SAAC across the quartiles (Q2, Q3, and Q4) were (1.042 (0.812, 1.338), 0.863 (0.668, 1.115), and 1.022 (0.787, 1.327)) and (1.48 (0.87, 2.52), 1.70 (1.01, 2.92), and 2.13 (1.19, 3.86)), respectively. As shown by the RCS plot, the serum 25(OH)D concentration was associated with the risk of AAC/SAAC in a U-shaped pattern ( P for nonlinearity <0.05). In addition, the degree of AAC decreased at first and then increased as the serum 25(OH)D concentration increased. In conclusion, a U-shaped relationship existed between serum 25(OH)D concentration and the risk of AAC and SAAC. Consequently, the risk of AAC and SAAC may be mitigated with regular monitoring and vitamin D supplementation.

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Section: Discussionmentioning

confidence: 99%

Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study

Liu

Zuo

Wang

et al. 2023

International Journal of Clinical Practice

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“…In a 4-year longitudinal study, it was found that severe 25-hydroxyvitamin D insu ciency or de ciency was related to a higher risk of progression of aortic calci cation, which was four-fold higher than that in individuals with a normal 25-hydroxyvitamin D level [46]. But another study showed that AAC progression was not affected by high-dose 25-hydroxyvitamin D in aged African American females [47]. Although 25hydroxyvitamin D de ciency induces vascular calci cation, a high level of 25-hydroxyvitamin D may be related to poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Association between 25-hydroxyvitamin D and abdominal aortic calcification in US adults: Findings From NHANES 2013-2014

Wang

Chao

et al. 2022

Preprint

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Aims: This study aimed to explore the correlation of 25-hydroxyvitamin D and abdominal aortic calcification.Methods: In this cross-sectional study, the data were collected from NHANES (National Health and Nutrition Examination Survey) 2013–2014. Multivariable logistic regression was performed to determine the association of 25-hydroxyvitamin D and AAC. The non-linear relationship was analyzed using smooth curve fitting. Results: 3,040 participants with compete data were included for data analysis. The fully-adjusted model showed serum calcium and HDL levels were correlated with the severity of AAC, and 25-hydroxyvitamin D was closely correlated with plasma calcium and HDL levels. Furthermore, either a low or high level of 25-hydroxyvitamin D was positively correlated with an increased risk of severe AAC, and a U-shaped dose-response relationship (inflection point: 45.8ng/mL and 146ng/mL) was indicated. Conclusions: Either a high or low level of 25-hydroxyvitamin D was positively associated with an increased risk of severe AAC. It was suggested that clinicians should be cautious when prescribing 25-hydroxyvitamin D supplementation, and the mechanism underlying the correlation of 25-hydroxyvitamin D and AAC remains to be further confirmed.

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“…Multiple contributors, including traditional factors (age, hypertension, diabetes, and dyslipidemia) as well as non-traditional factors (hyperphosphatemia, calcium phosphate product, and parathyroid function), have been suggested to be involved in cardiac valve calcification in patients with CKD 6 . Vitamin D plays a central role not only in bone metabolism but also in the vasculature and may be involved in the process of vascular calcification 7 . Indeed, low levels of 25-hydroxyvitamin D [25(OH)D] or 1,25-dihydroxyvitamin D [1,25(OH) 2 D] have been reported to be associated with coronary artery and cardiac valve calcification in patients with risk factors for CVD and in the general population 8 – 10 .…”

Section: Introductionmentioning

confidence: 99%

1,25-dihydroxyvitamin D deficiency is independently associated with cardiac valve calcification in patients with chronic kidney disease

Kim

et al. 2022

Sci Rep

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Cardiac valve calcification is highly prevalent in patients with chronic kidney disease (CKD). Low vitamin D levels are associated with vascular calcification in CKD. However, the association between vitamin D levels and cardiac valve calcification is unknown. A total of 513 patients with pre-dialysis CKD were included in this cross-sectional study. Aortic valve calcification (AVC) and mitral valve calcification (MVC) were assessed using two-dimensional echocardiography. The associations between AVC and MVC and baseline variables were investigated using logistic regression analyses. In multivariable analysis, serum 1,25(OH)2D level was independently associated with AVC (odds ratio [OR], 0.87; P < 0.001) and MVC (OR, 0.92; P < 0.001). Additionally, age, diabetes, coronary heart disease, calcium × phosphate product, and intact parathyroid hormone levels were independently associated with AVC and MVC. Systolic blood pressure was independently associated with AVC. A receiver-operating characteristic (ROC) curve analysis showed that the best cutoff values of serum 1,25(OH)2D levels for predicting AVC and MVC were ≤ 12.5 and ≤ 11.9 pg/dl, respectively. Serum 1,25(OH)2D deficiency is independently associated with AVC and MVC in patients with CKD, suggesting that serum 1,25(OH)2D level may be a potential biomarker of AVC and MVC in these patients.

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Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

Cited by 8 publications

References 58 publications

Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study

Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study

Association between 25-hydroxyvitamin D and abdominal aortic calcification in US adults: Findings From NHANES 2013-2014

1,25-dihydroxyvitamin D deficiency is independently associated with cardiac valve calcification in patients with chronic kidney disease

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