Vitamin D Status Across Age Groups in Turkey: Results of 108742 Samples from a Private Laboratory

Mutlu, Gül Yeşiltepe; Aksu, Ekin Deniz; Bereket, Abdullah; Hatun, Şükrü

doi:10.4274/jcrpe.galenos.2019.2018.0097

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…PTH level was examined by electro chemiluminescence method in Siemens Advia Centaur device. Those with 25‐OHD level less than 12 ng/ml were considered as vitamin D deficient, those between 12 and 20 ng/ml were considered vitamin D insufficient and those with greater than 20 ng/ml were considered to have a normal vitamin D 19 . Patients diagnosed with COVID‐19 were divided into two groups.…”

Section: Methodsmentioning

confidence: 99%

Is vitamin D deficiency a risk factor for COVID‐19 in children?

Yılmaz

Şen

2020

Pediatric Pulmonology

112

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Objective Coronavirus disease 2019 (COVID‐19) is a global health problem that can result in serious complications. The aim of this study was to investigate the prevalence and clinical importance of vitamin D deficiency in children with COVID‐19. Material and Methods This study includes 40 patients who were diagnosed to have COVID‐19 and hospitalized with the real‐time reverse transcription polymerase chain reaction method, 45 healthy matched control subjects with vitamin D levels. The age of admission, clinical and laboratory data, and 25‐hydroxycholecalciferol (25‐OHD) levels were recorded. Those with vitamin D levels which are below 20 ng/ml were determined as Group 1 and those with ≥20 ng/ml as Group 2. Results Patients with COVID‐19 had significantly lower vitamin D levels 13.14 μg/L (4.19–69.28) than did the controls 34.81 (3.8–77.42) μg/L (p < .001). Patients with COVID‐19 also had significantly lower serum phosphorus (4.09 ± 0.73 vs. 5.06 ± 0.93 vs. (U/L) (p < .001)) values compared with the controls. The symptom of fever was significantly higher in COVID‐ 19 patients who had deficient and insufficient vitamin D levels than in patients who had sufficient vitamin D levels (p = .038). There was a negative correlation found between fever symptom and vitamin D level (r = −0.358, p = .023). Conclusion This is the first to evaluate vitamin D levels and its relationship with clinical findings in pediatric patients with COVID‐19. Our results suggest that vitamin D values may be associated with the occurrence and management of the COVID‐19 disease by modulating the immunological mechanism to the virus in the pediatric population.

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Section: Methodsmentioning

confidence: 99%

Is vitamin D deficiency a risk factor for COVID‐19 in children?

Yılmaz

Şen

2020

Pediatric Pulmonology

112

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“…Vitamin D deficiency is a commonly seen problem in Turkey. Even in a comprehensive study with more than 100 000 samples in Turkey (<20 ng/mL), vitamin D deficiency was found at a rate of 51% in the general population and 58% in adolescents 29. It was reported that the rate reached 61% in winter and 66% in the north of Turkey.…”

Section: Discussionmentioning

confidence: 98%

Vitamin D level, body mass index and fracture risk in children: vitamin D deficiency and fracture risk

Varkal¹,

Gülenç²,

Yıldız³

et al. 2021

Journal of Pediatric Orthopaedics B

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The objective of this study was to determine the impacts of preventable causes of fracture, such as vitamin D deficiency, disturbed calcium homeostasis and obesity on fracture occurrence in minor traumas. In this way, the effects of relevant parameters on fracture may be further elucidated. A prospective case-control study in children aged 2-18 years children with and without fractures was performed. Participants with a pediatric trauma score higher than 10 presenting to minor trauma were included to exclude the significant impact of severe trauma on fracture. The effects of obesity, parameters associated with vitamin D and Ca homeostasis on fracture occurrence were evaluated. Univariate and multivariate analyses were used to test for associations between fracture status and the assessed variables. The relationships between the variables and the odds of fracture occurrence were examined using logistic regression models. The sample consisted of 76 patients and 50 controls. There were no significant differences between the patients and controls in terms of age, sex, trauma type and pubertal period. The patients had a significantly higher mean BMI percentile (61.2 ± 30.7, 36.7 ± 30.7; P < 0.001). Likewise, patients were more likely than controls to have a lower mean 25(OH)D level and mean phosphorus level (respectively, 13.4 ± 7.0, 17.3 ± 7.8; P = 0.004, and 4.6 ± 0.7, 5.1 ± 0.8; P < 0.001). Moreover, fractures were substantially more frequent in children with vitamin D deficiency (<20 ng/ mL, χ 2 : 7.781, df: 1, P = 0.005). In the multivariate logistic model, BMI percentile and vitamin D levels remained significantly associated with increased odds of fracture [1.02 (1.01-1.04), P < 0.001 and 0.93 (0.89-0.98), P = 0.01]. The present study supports an association of high BMI and vitamin D deficiency with an increased odds of fracture occurrence in children. The findings may help physicians to reduce the risk factors of fracture by preventive efforts. Thus, unexpected health costs and morbidity may be minimized.

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“…Two groups were formed according to the patients' 25-OHD levels. 18 The 25-OHD and parathormone levels were evaluated as follows:…”

Section: Methodsmentioning

confidence: 99%

The Effect of Vitamin D Levels in Multisystem Inflammatory Syndrome in Children

Kan

Türe

Akın

et al. 2022

J Pediatr Infect Dis

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Objective Multiple factors being overweight, asthmatic, or being of Asian or black ethnic origins have been reported vis-à-vis the “multisystem inflammatory syndrome in children” (MIS-C). There is an association between these conditions and vitamin D deficiency, which explains why MIS-C is more common in these patients. In the present study, we attempted to retrospective evaluate the 25-hydroxy vitamin D levels of patients with MIS-C, its association with acute phase reactants, its treatment, and clinical status. Methods Patients aged between 1.5 months to 18 years with MIS-C were included in the study. All of the laboratory parameters, treatment, and response to the treatment were evaluated retrospectively. Two groups were formed. Patients had 25‐hydroxycholecalciferol D vitamin < 20 ng/mL in group 1 and ≥ 20 ng/mL in group 2. Results A total of 52 patients were included in the study. There was no statistical difference between groups in terms of acceptance of the intensive care unit treatment (p = 0.29) and response to the first-line treatment (p = 0.56). A lower median lymphocyte count (p = 0.01) and a higher median C-reactive protein (p = 0.04) and procalcitonin (p = 0.01) with N-terminal pro-B-type natriuretic peptide (p = 0.025) values were found in group 1. Conclusion Vitamin D deficiency was associated with an increased inflammatory response in children with MIS-C. More studies are required to determine the potential impact of vitamin D deficiency on the clinical outcome of MIS-C.

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Vitamin D Status Across Age Groups in Turkey: Results of 108742 Samples from a Private Laboratory

Cited by 5 publications

References 13 publications

Is vitamin D deficiency a risk factor for COVID‐19 in children?

Is vitamin D deficiency a risk factor for COVID‐19 in children?

Vitamin D level, body mass index and fracture risk in children: vitamin D deficiency and fracture risk

The Effect of Vitamin D Levels in Multisystem Inflammatory Syndrome in Children

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