Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain

Pennisi, Manuela; Bartolo, Giuseppe Di; Malaguarnera, Giulia; Bella, Rita; Lanza, Giuseppe; Malaguarnera, Michele

doi:10.1155/2019/3549402

Cited by 30 publications

(20 citation statements)

References 34 publications

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“…Fatigue is a common clinical condition characterized by decreased energy, concentration, and motivation that interferes with the activities of daily living. As such, fatigue is also associated with several physical and psychological symptoms, including pain, depression, distress, dyspnea, anxiety, and poor sleep quality [30]. Patients with an induced fatigue state show a reduced exercise tolerance and a post-exercise fatigue even after minimal physical activity, thus, suggesting that an impaired muscle function may occur behind this condition.…”

Section: Discussionmentioning

confidence: 99%

Decrease in Serum Vitamin D Level of Older Patients with Fatigue

et al. 2019

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Fatigue is characterized by reduced energy level, decreased muscle strength, and a variable degree of cognitive impairment. Recent evidences seem to link vitamin D deficiency to fatigue. The aim of this study was to assess and compare vitamin D status in a cohort of older subjects with and without fatigue. We recruited a total of 480 subjects, 240 patients with fatigue and 240 controls without fatigue, from the Cannizzaro Hospital of Catania (Italy). Fatigue severity was measured by the fatigue severity scale, whereas mental and physical fatigue were measured through the Wessely and Powell fatigue scale, respectively. We also measured several blood parameters and 25-OH vitamin D. Subjects with fatigue showed lower levels of vitamin D as compared with those without fatigue. Blood levels of parameters related to fatigue were normal in both groups of subjects, however, platelet, hemoglobin, hematocrit (p < 0.05), mean corpuscular volume, C-reactive protein (CRP), iron, vitamin B12, and folic acid (p < 0.001) were significantly higher in the fatigue group with respect to the control group. Moreover, compared to controls, patients showed higher scores in the physical (p < 0.001), mental (p < 0.001), and severity (p < 0.001) fatigue scales. Finally, vitamin D inversely correlated with fatigue severity (r = −0.428, p < 0.01), whereas creatine kinase and CRP levels did not correlate with vitamin D. In conclusion, our data showed a direct link between vitamin D and fatigue in older subjects, suggesting translational implications in the diagnosis and management of these patients.

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Section: Discussionmentioning

confidence: 99%

Decrease in Serum Vitamin D Level of Older Patients with Fatigue

et al. 2019

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“…Vitamin D is a neuroactive steroid that may mediate pain processes by modulating several signal transduction systems. Patients with statin-induced musculoskeletal pain often have low vitamin D levels [56]. Statins decrease cholesterol synthesis through the reversible block of the hydroxy-3-methylglutaryl-coenzyme A reductase.…”

Section: Discussionmentioning

confidence: 99%

Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study

et al. 2019

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Hypovitaminosis D (25-hydroxyvitamin D (25(OH)D) <75 nmol/L) is associated with neuropathic pain and varicella-zoster virus (VZV) immunity. A two-part retrospective hospital-based study was conducted. Part I (a case-control study): To investigate the prevalence and risk of hypovitaminosis D in postherpetic neuralgia (PHN) patients compared to those in gender/index-month/age-auto matched controls who underwent health examinations. Patients aged ≥50 years were automatically selected by ICD-9 codes for shingle/PHN. Charts were reviewed. Part II (a cross-sectional study): To determine associations between 25(OH)D, VZV IgG/M, pain and items in the DN4 questionnaire at the first pain clinic visit of patients. Independent predictors of PHN were presented as adjusted odds ratios(AOR) and 95% confidence intervals (CI). Prevalence (73.9%) of hypovitaminosis D in 88 patients was high. In conditional logistic regressions, independent predictors for PHN were hypovitaminosis D (AOR3.12, 95% CI1.73–5.61), malignancy (AOR3.21, 95% CI 1.38–7.48) and Helicobacter pylori-related peptic ulcer disease (AOR3.47, 95% CI 1.71–7.03). 25(OH)D was inversely correlated to spontaneous/brush-evoked pain. Spontaneous pain was positively correlated to VZV IgM. Based on the receiver operator characteristic curve, cutoffs for 25(OH)D to predict spontaneous and brush-evoked pain were 67.0 and 169.0 nmol/L, respectively. A prospective, longitudinal study is needed to elucidate the findings.

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“…Oral microbiota changes are able to modulate the connection between oral bacteria and humans causing diseases (21,22). Oral microbiota seems to influence OSCC through the carcinogenetic modulation of cell metabolism (such as modifying the concentration of nutrients and vitamins), thereby promoting the production of different cytokines known to be involved in several pathological conditions (23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Association of oral dysbiosis with oral cancer development (Review)

et al. 2020

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Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer. Numerous risk factors mainly related to unhealthy habits and responsible for chronic inflammation and infections have been recognized as predisposing factors for oral carcinogenesis. Recently, even microbiota alterations have been associated with the development of human cancers. In particular, some specific bacterial strains have been recognized and strongly associated with oral cancer development (Capnocytophaga gingivalis, Fusobacterium spp., Streptococcus spp., Peptostreptococcus spp., Porphyromonas gingivalis and Prevotella spp.). Several hypotheses have been proposed to explain how the oral microbiota could be involved in cancer pathogenesis by mainly paying attention to chronic inflammation, microbial synthesis of cancerogenic substances, and alteration of epithelial barrier integrity. Based on knowledge of the carcinogenic effects of dysbiosis, it was recently suggested that probiotics may have anti-tumoral activity. Nevertheless, few data exist with regard to probiotic effects on oral cancer. On this basis, the association between the development of oral cancer and oral dysbiosis is discussed focusing attention on the potential benefits of probiotics administration in cancer prevention.

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Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain

Cited by 30 publications

References 34 publications

Decrease in Serum Vitamin D Level of Older Patients with Fatigue

Decrease in Serum Vitamin D Level of Older Patients with Fatigue

Hypovitaminosis D in Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study

Association of oral dysbiosis with oral cancer development (Review)

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