Vitamin D serum levels and vitamin D receptor FokI polymorphism on tuberculosis children in Palembang, Indonesia

Karmila, Ariesti; Aditiawati,; Nazir, Muhammad; Yangtjik, Kiagus; Yuwono,

doi:10.1186/1687-9856-2013-s1-p202

Cited by 3 publications

(4 citation statements)

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“…FokI polymorphisms were found in 83.9% of infected patients and 75.0% of uninfected patients. This is in contrast with the findings of Setiabudiawan and Karmila, who found FokI polymorphism was significantly different between case and control TB [1,13].…”

Section: Levels Of Cathelicidincontrasting

confidence: 99%

The Role of Vitamin D, Vitamin D Receptor Gene Foki Polymorphism, and Cathelicidin in Tuberculosis Infection in Children

2019

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Objective: Recent studies have reported that vitamin D has an important role in tuberculosis. Polymorphism of single nucleotide polymorphism (SNP) rs2228570 or FokI will generate proteins with various amino acid lengths, and affect the molecular physiological roles of vitamin D. Cathelicidin acts as an antimicrobial directly against Mycobacterium tuberculosis (Mtb) and mediator autophagy by macrophages induced by vitamin D. This study aims to determine the role of vitamin D, vitamin D receptor gene SNP rs2228570 (FokI), and plasma levels of cathelicidin in children with tuberculosis infection. Methods: This cross-sectional was conducted on children aged £14 y who had close contacts with an adult who had sputum smear positive for acid-fast bacilli indicating pulmonary TB. The children were divided into two groups: those with and those without TB infection. Demographic data and blood samples were taken from children participating in this study to examine polymorphisms and cathelicidin plasma levels, and to determine the association between these levels in children with and without TB infection. Results: There were no differences in the proportion of genotype and allele of SNP rs2228570 vitamin D receptor gene (FokI), polymorphisms of VDR, and cathelicidin plasma levels between children with and without TB infection (p>0.05). However, nutritional status and levels of cathelicidin by age category increased the risk of TB infection (p<0.05). Conclusion: Cathelicidin level in children with TB infection lower than without. Vitamin D and FokI polymorphism did not play role in TB infection.

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Section: Levels Of Cathelicidincontrasting

confidence: 99%

The Role of Vitamin D, Vitamin D Receptor Gene Foki Polymorphism, and Cathelicidin in Tuberculosis Infection in Children

2019

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“…It caused by the Adamkiewicz artery, a segmental blood vessel located in the thoracolumbar vertebral region. This artery supplies the body of the vertebrae and might carry MTB bacteria to the vertebrae [4,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Research performed by Ramdan on spine TB patients also suggests that most spinal TB patients suffer from vitamin D deficiency [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 as an anti tuberculosis supplement in spinal tuberculosis treatment

Rajasa¹,

Rasyid²,

Tiksnadi³

et al. 2018

Prog Orthop Sci

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Background: Tuberculous infection susceptibility emerges in individuals with low levels of vitamin D. C-reactive protein (CRP) and erythrocyte sediment rate (ESR) are low during the intensive phase of anti-tuberculous drug (ATD) therapy. Cathelicidin, which is induced by vitamin D, has been proven to reduce the inflammatory process. Methods: This single-blind randomized control trial compared the efficacy of vitamin D in lowering CRP and ESR. The research was conducted at the Hasan Sadikin Hospital Outpatient Clinic and the Clinical Pathology Laboratory from March 2017 through August 2017. Tuberculous infected patients enrolled in the study were assigned to one of two groups; one received vitamin D supplementation, the other didn't received. The Willcoxon statistical test was used to examine the value of CRP in two groups, and the unpaired t-test was used to evaluate ESR values for both groups. Results: The CRP and ESR values in the group receiving vitamin D were significantly lower than in the placebo group (p < 0.05), indicating that vitamin D is beneficial in treating tuberculous infection.

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“…Karmila and Kibiringer reported that a person with vitamin D deficiency has increased vulnerability to TB infection compared to a person without vitamin D deficiency. Research performed by Ramdan on spine TB patients also suggests that most spinal TB patients suffer from vitamin D deficiency [14][15][16].…”

Section: Discussionmentioning

confidence: 99%