Vitamin D receptor gene start codon polymorphism (<i>FokI</i>) and bone mineral density in healthy male subjects

Kanan, Raed M; Varanasi, Satya S.; Francis, Roger M.; Parker, Louise; Datta, Harish K.

doi:10.1046/j.1365-2265.2000.01059.x

Cited by 38 publications

(19 citation statements)

References 27 publications

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“…Data on fetal and infant life and childhood had previously been collected prospectively. Between October 1996 and December 1998, questionnaires on health and lifestyle were completed and study members attended for clinical examination [3][4][5][6][7][8][9][10][11]. Ethical approval for the study was obtained from the appropriate Local Research Ethics Committees and all participants gave their written consent.…”

Section: Methodsmentioning

confidence: 99%

Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study

Pearce

Unwin

Parker

et al. 2005

Diabetes Metabolism Res

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Section: Methodsmentioning

confidence: 99%

Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study

Pearce

Unwin

Parker

et al. 2005

Diabetes Metabolism Res

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“…These polymorphisms of VDR may have different functions depending on their locations (Slattery 2007). The FokI polymorphism is located near the 5′-UTR region of the gene within the DNA-binding domain (Kanan et al 2000;Ingles et al 2001;Kim et al 2001;Chen et al 2002;Tworoger et al 2009). Studies have explored the associations between VDR polymorphisms and human cancers, including colorectal adenomas, prostate cancer, breast cancer, bladder cancer and melanoma (Kearney et al 1996;Deeb et al 2007;Slattery 2007;Ishihara et al 2008;Theodoratou et al 2008;Tang et al 2009).…”

Section: Discussionmentioning

confidence: 99%

FokI Polymorphism of the Vitamin D Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study

Liu

Wang

Liu

et al. 2015

Tohoku J. Exp. Med.

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Vitamin D is a potential protective agent against cancer, and its activity is mediated mainly by vitamin D receptor (VDR). The FokI polymorphism (rs10735810) represents a T-to-C transition (ATG to ACG) in exon 2 of the VDR gene, and this ATG represents the translation-initiation codon, encoded by the f allele. The FokI polymorphism results in the generation of a protein shortened by three amino acids, translated from the downstream ATG codon (the F allele). We investigated the relationship between the FokI polymorphism and gastric cancer in a Chinese Han population. A total of 187 patients and 212 healthy controls were enrolled. The FokI polymorphism was detected by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis. The f allele frequency was higher in patients than that in controls (51.6% and 43.6%, P < 0.05). Multivariate logistics regression analysis revealed patients with the f allele (Ff + ff) showed a higher risk of gastric cancer [odds ratio (95% confidence interval) 2.73 (1.13~4.32)]. Patients with the f allele (Ff + ff) also presented a poorly differentiated type of gastric cancer (P < 0.05) and higher levels of C-reactive protein on admission than the FF group (5.5 ± 2.4 mg/L vs. 3.4 ± 1.3 mg/L, P < 0.05). Here, we show an association between the VDR FokI polymorphism and the susceptibility to gastric cancer, which may be helpful for early detection of high-risk individuals with the f allele for gastric cancer. Conversely, the F allele may be a protective factor against gastric cancer.

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“…Although no significant differences in ligand affinity, DNA binding, or transactivation activity have been found between these two VDR forms when studied independently (Laaksonen et al, 2004), in transient transfection assays with a vitamin D-responsive reporter gene, the shorter VDR variant displayed higher potency than the longer one (Gross et al, 1998). It has been hypothesized that a less active VDR could be associated with either an increased susceptibility to cancer risk or to a more aggressive form of the disease (Kanan et al, 2000). In this study, we found that the FokI polymorphisms of the VDR gene were closely associated with GBC risk, suggesting that this locus could be used as a molecular marker for GBC.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort

Li¹,

Yuan²,

Ning³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to test for the possible association between vitamin D receptor (VDR) genetic variants and susceptibility to gallbladder cancer (GBC). A total of 291 GBC cases were recruited and 396 gender-and age-matched healthy volunteers were enrolled as controls. The VDR gene polymorphisms were determined in all subjects. The genotype and the allele frequencies of ApaI, BsmI, and TaqI polymorphisms were not significantly different between GBC subjects and controls. However, the genotype and allele frequencies of the FokI C>T polymorphism were significantly different between GBC subjects and controls. The FokI TT genotype was in markedly higher frequency in GBC subjects compared to controls (38.14 vs 22.73%, P < 0.001). Using TT as the reference genotype, multivariate logistic regression analysis showed that CC genotype carriers had a higher risk of GBC (adjusted odds ratio (OR) = 3.423, adjusted P = 0.001) with adjustment for age, gender, smoking status, alcohol use, and gallstone presence, as well as the serum 1,25(OH)2D level. Carriers of the CT genotype also had a higher risk of GBC (adjusted OR = 1.992, adjusted

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Vitamin D receptor gene start codon polymorphism (FokI) and bone mineral density in healthy male subjects

Abstract: The study shows that in this population of healthy men there is a weak association between lumbar spine bone mineral density and FokI restriction fragment length polymorphism at the translation initiation site of the vitamin D receptor gene.

Cited by 38 publications

References 27 publications

Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study

Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study

FokI Polymorphism of the Vitamin D Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study

Vitamin D receptor genetic variants are associated with susceptibility of gallbladder adenocarcinoma in a Chinese cohort

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