Vitamin D receptor gene polymorphisms are not associated with alopecia areata

Akar, Ahmet; Orkunoglu, Funda; Tunca, Mustafa; Taştan, Halis Bülent; Kurumlu, Zafer

doi:10.1111/j.1365-4632.2007.03140.x

Cited by 14 publications

(12 citation statements)

References 13 publications

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“…Polymorphisms of the VDR gene have been shown to increase susceptibility to other autoimmune diseases, including Graves’ disease and psoriasis [45, 46]. However, in two studies [36, 37] no such polymorphisms were associated with AA. However, only 25 and 32 patients with AA were studied respectively, and there were no investigations of polymorphisms by racial or ethnic group [36, 37].…”

Section: Micronutrientsmentioning

confidence: 99%

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The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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Section: Micronutrientsmentioning

confidence: 99%

“…However, in two studies [36, 37] no such polymorphisms were associated with AA. However, only 25 and 32 patients with AA were studied respectively, and there were no investigations of polymorphisms by racial or ethnic group [36, 37]. …”

Section: Micronutrientsmentioning

confidence: 99%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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“…The three functional polymorphisms genotypic frequency was not different as compared with AA patients than healthy controls (p= 0.7722, p=0.5807, p=0.8292, respectively). Akar et al [13] examined 32 patients with AA and 27 healthy control subjects the distribution of genotype and allelic frequencies of BsmI, ApaI and TaqI polymorphisms of the VDR gene in case-control populations. Akar et al findings correlated with our results.…”

Section: Discussionmentioning

confidence: 99%

“…PCR products were digested with the restriction en-zymes (BsmI) according to the manufacturer's in¬structions, and Restriction fragments of BsmI polymorphisms in VDR gene were electrophoresed on an 2% agarose and 1% nusieve agarose gel stained with ethidium bromide, and the genotypes were determined under ultraviolet (UV) illumination. BsmI genotypes: BB (825 bp), Bb (825, 650, and 125 bp), and bb (650 and 125 bp) [13].…”

Section: Bsmi Pcr and Restriction Digestion;mentioning

confidence: 99%