Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer risk

Abstract

Abstract

Association Between VDR Polymorphisms and Breast Cancer: An Updated and Comparative Meta-analysis of Crude and Adjusted Odd Ratios

“…Case-control studies on Fok1 in breast cancer showed some evidence of increased risk among ff carriers (Sinotte et al, 2008;Gapska et al, 2009;McKay et al, 2009), which was confirmed by some later metaanalysis Tang et al, 2009;. However, these studies also reported some decreased risk among ff carriers (Anderson et al, 2011), or no association with breast cancer (Curran et al, 1999;Guy et al, 2004;John et al, 2007;Abbas et al, 2008;Engel et al, 2012;Rollison et al, 2012;Fuhrman et al, 2013;Mishra et al, 2013;Shahbazi et al, 2013). Similarly, mixed results have been observed concerning the relationship between other polymorphisms and the risk of breast cancer development.…”

“…2013; Shahbazi et al, 2013) but not in others (Buyru et al, 2003;Hefler et al, 2004;VandeVord et al, 2006;Trabert et al, 2007;Sinotte et al, 2008;Gapska et al, 2009;McKay et al, 2009;Anderson et al, 2011;Rollison et al, 2012;Mishra et al, 2013); Apa1 was found with positive relationship in some breast cancer studies (Curran et al, 1999;Sillanpaa et al, 2004;Dalessandri et al, 2012), but negative in others (Cui et al, 2001;Hou et al, 2002;Chakraborty et al, 2009;Anderson et al, 2011;Engel et al, 2012;Mishra et al, 2013); the same as Taq1, with associations in some studies (Cui et al, 2001;, but not in others (Curran et al, 1999;Dunning et al, 1999;Lundin et al, 1999;Hou et al, 2002;Newcomb et al, 2002;Buyru et al, 2003;Sillanpaa et al, 2004;John et al, 2007;Abbas et al, 2008;Chakraborty et al, 2009;Gapska et al, 2009;Anderson et al, 2011;Engel et al, 2012;Mishra et al, 2013); Cdx2, positive in some studies (Anderson et al, 2011;Yao et al, 2012; but not in others (Abbas et al, 2008;Zhou et ...…”

Vitamin D Receptor Polymorphisms and Breast Cancer Risk: Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium

“…We were unable to examine VDR genotype interactions with circulating levels of 25(OH)D, the integrated marker of vitamin D status from diet, supplements, and UVB exposure. However, in a population-based case-control study (14) and a nested case-control study (8) These results from a pooled analysis of data from six large cohorts suggest that the rs2228570 (FokI) and rs1544410 (BsmI) polymorphisms in VDR may have a small role in breast cancer susceptibility. Although both genetic findings support the hypothesis that vitamin D status plays a role in breast cancer etiology, the associations were modest and may be due to chance.…”

“…In a large nested case-control study, the rs2228570 (FokI) ff genotype was associated with a (9)(10)(11)(12)(13)(14), have not reported similar associations. The presence of the rs2228570 (FokI) f allele in the 5 ¶-promoter region of the VDR results in production of a VDR protein that is three amino acids longer and less effective as a transcriptional activator (15).…”

Do VDR Gene Polymorphisms Contribute to Breast Cancer?

“…The important and intensively studied single nucleotide polymorphisms (SNPs) of VDR are, FokI (rs2228570), VDR-BsmI (rs1544410), VDR-TaqI (rs731236), VDRApaI (rs7975232) and Poly(A) (Alimirah et al, 2011). Over the years, most of The molecular epidemiological studies have been done to relate the associations of important VDR polymorphisms with breast cancer (Curran et al, 1999;Ingles et al, 2000;Bretherton et al, 2001;Hou et al, 2002;Buyru et al, 2003;Guy et al, 2004;Sillanpaa et al, 2004;Chen et al, 2005;Lowe et al, 2005;John et al, 2007;Mc Cullough et al, 2007;Trabert et al, 2007;Abbas et al, 2008;Barroso et al, 2008;Sinotte et al, 2008;Chakraborty et al, 2009;McKay et al, 2009;Rollison et al, 2011;Huang et al, 2012;Mishra et al, 2013;Du et al, 2014 Ethnic Variation in VDR Gene Polymorphisms: VDR gene show sequence level dissimilarity in the different populations, both at the 5' and 3' termini (Trabert et al, 2007). Epidemiological studies have frequently reported that the fundamental features of the population with varying ethnicities can alter the links between VDR gene polymorphisms and carcinoma.…”