Do VDR Gene Polymorphisms Contribute to Breast Cancer?

Abstract

Breast cancer is the first or second leading cancer among females across the globe. A large number of studies have been conducted to assess any relationship between vitamin D receptor (VDR) gene polymorphisms and breast cancer development. Epidemiological studies have indicated that ethnic traits exhibited by a group of people with a common ancestry and culture, alter the link between VDR gene and breast cancer. It has been hypothesized that VDR polymorphisms have the capacity to impact both on incidence of breast cancer occurrence and to predict its outcome. A survey was here conducted to assess and compare the impact of vitamin D receptor gene polymorphisms Fok1, Bsm1, Taq1, Apa1 and poly (A) on development of breast cancer. Information was obtained from electronic databases including PubMed and Google Scholar for articles published during the period from 1996 to 2015. This search was achieved by using the terms "genetics", "breast cancer", "VDR gene", "polymorphisms". However, due to inconsistent results, no conclusive statements could be presented about the significance of the VDR genotype as far as the development of breast carcinoma is concerned'

Association of vitamin D receptor gene polymorphisms with breast cancer risk in an Egyptian population

“…Moreover, many recent reports found a marked increased susceptibility to breast cancer between women carrying ApaI GG genotype compared with women carrying genotype TT. 4,9,37,50 On the contrary, McCullough et al and Mishra et al reported no significant relation between the ApaI variants and breast cancer prevalence among Indian and Caucasian women. 32,49,[51][52][53] Interestingly, our findings indicated the existence of marked difference between patients and control samples of women carrying TC genotype of VDR TaqI (rs731236).…”

Vitamin D Receptor Polymorphism and Cancer: An Update

“…Furthermore, heterogeneity by tumor subtype was also seen for rs1544410, rs7967152 and rs2239186 VDR polymorphisms in Europeans (30). These case-control and meta-analysis studies suggest that VDR polymorphism may be associated with increased risk of breast cancer (Table I) and poly(A) on development of breast cancer from 1996 to 2015 and suggested that due to the inconsistent results of various studie, no conclusive evidence associates the risk of breast cancer with VDR polymorphism (32). Similarly, the inconsistent results of the studies shown in Table I suggest the need for further research.…”

Vitamin D and Breast Cancer: Latest Evidence and Future Steps

“…25 BsmI but not Fok1 was associated with the risk of breast cancer among Iranian women. 49 However, Shaikh et al 50 in their mini review compare the impact of VDR gene polymorphisms, Fok1, Bsm1, Taq1, Apa1, and poly(A), on the development of breast cancer and showed inconsistent results, with no conclusive statements about the significance of the VDR genotype on breast carcinoma development ( Table 2).…”