Vitamin D and Breast Cancer: Latest Evidence and Future Steps

Atoum, Manar; Alzoughool, Foad

doi:10.1177/1178223417749816

Cited by 61 publications

(53 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TNBC represents a challenge for the development of therapeutic strategies due to the degree of cell dedifferentiation and the dysregulation of molecules involved in the control of proliferation, apoptosis, migration, invasion, and immune response [4]. Vitamin D deficiency has been associated with an increased risk of developing breast cancer [18, 40]. In fact, low levels of calcitriol or its precursor calcidiol have been significantly associated with TNBC in African-American women, including several autoimmune and chronic inflammatory disorders [18, 41, 42].…”

Section: Discussionmentioning

confidence: 99%

Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1βand TNF-α

Martínez-Reza

Díaz

Barrera

et al. 2019

Journal of Immunology Research

View full text Add to dashboard Cite

Triple-negative breast cancer (TNBC) is one of the most aggressive tumors, with poor prognosis and high metastatic capacity. The aggressive behavior may involve inflammatory processes characterized by deregulation of molecules related to the immunological responses in which interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) are involved. It is known that calcitriol, the active vitamin D metabolite, modulates the synthesis of immunological mediators; however, its role in the regulation of IL-1βand TNF-αin TNBC has been scarcely studied. In the present study, we showed that TNBC cell lines SUM-229PE and HCC1806 expressed vitamin D, IL-1β, and TNF-αreceptors. Moreover, calcitriol, its analogue EB1089, IL-1β, and TNF-αinhibited cell proliferation. In addition, we showed that synthesis of both IL-1βand TNF-αwas stimulated by calcitriol and its analogue. Interestingly, the antiproliferative activity of calcitriol was significantly abrogated when the cells were treated with anti-IL-1βreceptor 1 (IL-1R1) and anti-TNF-αreceptor type 1 (TNFR1) antibodies. Furthermore, the combination of calcitriol with TNF-αresulted in a greater antiproliferative effect than either agent alone, in the two TNBC cell lines and an estrogen receptor-positive cell line. In summary, this study demonstrated that calcitriol exerted its antiproliferative effects in part by inducing the synthesis of IL-1βand TNF-αthrough IL-1R1 and TNFR1, respectively, in TNBC cells, highlighting immunomodulatory and antiproliferative functions of calcitriol in TNBC tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1βand TNF-α

Martínez-Reza

Díaz

Barrera

et al. 2019

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…Since vitamin D also exhibits antiproliferative and pro-differentiating properties, its deficiency has been correlated with the progression of several malignancies [ 70 , 215 , 216 , 217 , 218 , 219 ], especially breast [ 220 , 221 , 222 , 223 ], ovarian [ 224 , 225 ] and skin tumours [ 226 , 227 , 228 , 229 ].…”

Section: Vitamin D: State Of the Artmentioning

confidence: 99%

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi

Perrone

Napolitano

et al. 2020

Cancers

View full text Add to dashboard Cite

Vitamin D is a fat-soluble steroid hormone playing a pivotal role in calcium and phosphate homeostasis as well as in bone health. Vitamin D levels are not exclusively dependent on food intake. Indeed, the endogenous production—occurring in the skin and dependent on sun exposure—contributes to the majority amount of vitamin D present in the body. Since vitamin D receptors (VDRs) are ubiquitous and drive the expression of hundreds of genes, the interest in vitamin D has tremendously grown and its role in different diseases has been extensively studied. Several investigations indicated that vitamin D action extends far beyond bone health and calcium metabolism, showing broad effects on a variety of critical illnesses, including cancer, infections, cardiovascular and autoimmune diseases. Epidemiological studies indicated that low circulating vitamin D levels inversely correlate with cutaneous manifestations and bone abnormalities, clinical hallmarks of neurofibromatosis type 1 (NF1). NF1 is an autosomal dominant tumour predisposition syndrome causing significant pain and morbidity, for which limited treatment options are available. In this context, vitamin D or its analogues have been used to treat both skin and bone lesions in NF1 patients, alone or combined with other therapeutic agents. Here we provide an overview of vitamin D, its characteristic nutritional properties relevant for health benefits and its role in NF1 disorder. We focus on preclinical and clinical studies that demonstrated the clinical correlation between vitamin D status and NF1 disease, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy.

show abstract

“…Data are required to decide whether there is a limit for cancer-causing impacts to show and, furthermore, to characterize the measurements and length of exposure. Studies are required to connect lethal signs with conceivable hereditary polymorphism, age, sexual orientation, wholesome status, and the defensive part of vitamins, minerals, and [73]. In Bangladesh, there should be some steps to check and control the concentration of arsenic in the drinking water.…”

Section: Controlmentioning

confidence: 99%

Arsenic: A Harmful and Desecrate Compound for the Humans

Chandra

Saini

Gupta

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Arsenic toxicity has become a burgeoning concern as several millions of people are exposed to this chemical through drinking water contamination by arsenic remains a major public health problem. Acute and chronic arsenic exposure through drinking water has been reported in many countries of the world, where a large proportion of drinking water is contaminated with high concentrations of arsenic. As contamination in groundwater has been found in more than 105 countries around the world, it has become the worldwide health problem as several millions of people are exposed to this toxicant. Arsenic contamination of different countries includes Bangladesh, India, Vietnam, Nepal, Thailand, and Chili is the major affected countries where inorganic arsenic in the groundwater with high concentration is seen. Arsenic is one of the most toxic metals which is originated from the natural environment. The catastrophe is that the majority of human arsenic toxicity is from polluted drinking water rather than agricultural sources (fertilizers or pesticides). The different areas across the Gangetic plains in Nepal and India also recently reported being affected by the arsenic. The hippocampus is a part of the limbic system that is crucial to memory function and spatial navigation. Hippocampus lesions in humans produce devastating impairments in declarative memory, and similar results have been seen in non-human primates with hippocampus neurobehavioral disorders.

show abstract

Vitamin D and Breast Cancer: Latest Evidence and Future Steps

Cited by 61 publications

References 83 publications

Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1βand TNF-α

Calcitriol Inhibits the Proliferation of Triple-Negative Breast Cancer Cells through a Mechanism Involving the Proinflammatory Cytokines IL-1βand TNF-α

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Arsenic: A Harmful and Desecrate Compound for the Humans

Contact Info

Product

Resources

About