Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis

Kılıç, Sevilay; Sılan, Fatma; Hız, Meliha Merve; Işık, Selda; Öğretmen, Zerrin; Özdemir, Öztürk

doi:10.18176/jiaci.0020

Cited by 33 publications

(21 citation statements)

References 13 publications

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“…According to the results of our study, the additive and dominant models for polymorphisms of VDR also produced insignificant results, coinciding with the results of a recent study by Kılıç et al. [33]. Accordingly, we can conclude that osteoporosis is a complex disease with a multifactorial etiology.…”

Section: Discussionsupporting

confidence: 91%

Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta‐analysis

Chen

Fang

2016

The Kaohsiung J of Med Scie

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In this study, we aimed to assess the relationship between vitamin D receptor gene polymorphisms and osteoporosis in the Han Chinese population. Articles regarding associations between vitamin D receptor polymorphisms (ApaI rs7975232 and BsmI rs1544410) and osteoporosis were retrieved from databases in November 2014. Eligible studies were tested by the Hardy-Weinberg equilibrium. The odds ratio and 95% confidence interval (95% CI) were analyzed to evaluate the strength of the associations. Pooled effect estimates were derived using a fixed-effect model and a random-effect model according to the heterogeneity of the test results. A subgroup analysis by study type and a sensitivity analysis based on studies that conform to the Hardy-Weinberg equilibrium and studies with postmenopausal women as participants were performed. This meta-analysis involved 15 eligible studies including 1580 cases and 1389 controls. The pooled estimated odds ratios in the dominant and additive genetic models were 0.73 (95% CI: 0.46-1.14, p=0.17) and 1.01 (95% CI: 0.77-1.33, p=0.81), respectively, for rs7975232 and 1.01 (95% CI: 0.81-1.26, p=0.91) and 1.01 (95% CI: 0.77-1.33, p=0.92), respectively, for rs1544410. The subgroup analysis showed that regardless of the dominant or additive genetic model, the effect of pooled odds ratios for rs7975232 and rs1544410 was insignificant. The sensitivity analysis also showed that the pooled effect was not significantly changed. In conclusion, no evidence of association is apparent between polymorphisms of vitamin D receptor genes and osteoporosis risk in the Han Chinese population.

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Section: Discussionsupporting

confidence: 91%

Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta‐analysis

Chen

Fang

2016

The Kaohsiung J of Med Scie

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“…On the other hand, the keratinocytes are not only a source of vitamin D but also a responder to its active form through vitamin D receptor (VDR). Moreover, it has already been published that the polymorphisms of VDR increased the risk of AD in some populations . Mice lacking the VDR or the enzyme (CYP27B1) producing its ligand 1,25(OH)2 D show defective epidermal differentiation .…”

Section: Discussionmentioning

confidence: 99%

Association of antioxidants and vitamin D level with inflammation in children with atopic dermatitis

et al. 2019

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Background Changing the resources of vitamin D and antioxidant nutrients may affect the course of allergic diseases. The aim of the study was to investigate the association between CoQ10, vitamin D, retinol, and α‐tocopherol serum levels and severity of atopic dermatitis (AD) in children. Methods Twenty‐nine children with AD aged from 1 to 15 years were enrolled into the study. The severity of AD was categorized into mild or moderate (≤50 points in SCORAD – Scoring Atopic Dermatitis index) and severe (>50 SCORAD points). The control group was comprised of 22 children with negative history of allergy aged from 2 to 15. The serum measurements included vitamin D, retinol, α‐tocopherol, CoQ10, C‐reactive protein (CRP), complete blood count (CBC), and total immunoglobulin E (IgE). Results Low vitamin D concentration (<20 ng/ml) was observed mainly in patients with severe AD (77.8%), compared to children with mild or moderate AD (25%) or the control group (31.8%). Concentration of retinol was decreased significantly in patients with severe AD (median 1.32 μmol/l), compared to children with mild and moderate AD (median 1.66 μmol/l), but not to the control. Among inflammatory markers, only the group with severe AD demonstrated significantly elevated platelet count (PLT), red blood cell distribution width (RDW), and eosinophil count (EO). Retinol level correlated with PLT (R = −0.7; P = 0.003), white blood count (WBC) (R = −0.54; P = 0.01), total IgE (R = −0.51; P = 0.016), mean platelet volume (MPV) (R = 0.51; P = 0.02), and also with a disease severity index, SCORAD (R = −0.55; P = 0.007), whereas vitamin D level correlated only with MPV (R = 0.61; P = 0.003). No significant changes were found in tocopherol and CoQ10 levels between groups. Conclusions Children with AD should be routinely tested for vitamin D deficiency, especially during disease exacerbation. Our results confirmed correlation of serum inflammatory markers with decreased concentration of vitamin A in children with AD. This finding, however, might be an effect of severe stage of disease and not only of inadequate intake of retinol in the diet.

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“…The common polymorphisms in VDR and vitamin D-metabolizing genes have been investigated for their role in AD susceptibility. The VDR BsmI polymorphism increased the risk of AD in a Turkish population, and a specific haplotype of VDR BsmI, ApaI, and TaqI polymorphisms was overrepresented in severe AD patients in a German population [132,133]. In another report, among 6 common polymorphisms in CYP24A1 and CYP27B1, CYP24A1rs2248359C allele and a specific haplotype were associated with an increased risk of severe AD [134].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

141

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis

Abstract: The VDR Fok1, TaqI, and ApaI gene polymorphisms were not associated with the risk of atopic dermatitis in the Turkish population but the BsmI polymorphism was found to increase risk.

Cited by 33 publications

References 13 publications

Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta‐analysis

Lack of association between vitamin D receptor polymorphisms ApaI (rs7975232) and BsmI (rs1544410) and osteoporosis among the Han Chinese population: A meta‐analysis

Association of antioxidants and vitamin D level with inflammation in children with atopic dermatitis

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

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