Vitamin D receptor found in human sperm

Corbett, Sean T.; Hill, Oya; Nangia, Ajay K.

doi:10.1016/j.urology.2006.09.011

Cited by 89 publications

(65 citation statements)

References 13 publications

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“…VDR is expressed predominantly in adult germ cells, consistent with a high postpubertal VDR expression (Walters 1984, Osmundsen et al 1989, Blomberg Jensen et al 2010b) and the immunohistochemical (IHC) and immunocytochemical (ICC) studies using different VDR antibodies ( Fig. 3; Johnson et al 1996, Nangia et al 1998, Corbett et al 2006, Blomberg Jensen et al 2010b. VDR was also detected in spermatogonia, spermatocytes, and Sertoli cells in roosters (Oliveira et al 2008).…”

Section: Introductionmentioning

confidence: 69%

“…The presence of VDR in human sperm supported the observed VDR expression during earlier stages of spermatogenesis as spermatozoa are virtually transcriptionally silent (Habib et al 1990, Nangia et al 1998, Corbett et al 2006, Aquila et al 2008, Blomberg Jensen et al 2010b. VDR expression was observed in only a fraction of human spermatogonia and spermatocytes, while it was expressed in most spermatids (Blomberg Jensen et al 2010b).…”

Section: Vitamin D and Male Reproductionmentioning

confidence: 78%

“…Spermatozoa are highly compartmentalized cells and each compartment has different functions reflected by the spatial expression of several ion channels, transporters, etc., that are confined to a particular compartment (Publicover et al 2007). All studies investigating VDR expression in mature human spermatozoa showed VDR expression in the postacrosomal part of the head, midpiece, and in the neck region (Corbett et al 2006, Aquila et al 2008, Blomberg Jensen et al 2010b. Moreover, the reported pattern of VDR expression was comparable with the expression of VD-binding protein in the postacrosomal region, neck, and midpiece of human spermatozoa (Yu et al 1994).…”

Section: Vitamin D and Male Reproductionmentioning

confidence: 99%

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Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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The spectrum of vitamin D (VD)-mediated effects has expanded in recent years, and VD is now recognized as a versatile signaling molecule rather than being solely a regulator of bone health and calcium homeostasis. One of the recently identified target areas of VD is male reproductive function. The VD receptor (VDR) and the VD metabolizing enzyme expression studies documented the presence of this system in the testes, mature spermatozoa, and ejaculatory tract, suggesting that both systemic and local VD metabolism may influence male reproductive function. However, it is still debated which cell is the main VD target in the testis and to what extent VD is important for sex hormone production and function of spermatozoa. This review summarizes descriptive studies on testicular VD metabolism and spatial distribution of VDR and the VD metabolizing enzymes in the mammalian testes and discusses mechanistic and association studies conducted in animals and humans. The reviewed evidence suggests some effects of VD on estrogen and testosterone biosynthesis and implicates involvement of both systemic and local VD metabolism in the regulation of male fertility potential.

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Section: Introductionmentioning

confidence: 69%

Section: Vitamin D and Male Reproductionmentioning

confidence: 78%

Section: Vitamin D and Male Reproductionmentioning

confidence: 99%

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Vitamin D metabolism, sex hormones, and male reproductive function

Jensen¹

2012

Reproduction

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“…Thirty-seven tissues are known to possess a VDR, the expression of which, coupled with the increased evidence involving VDR in processes other than mineral homeostasis, has prompted the generation and testing of therapeutic VDR ligands in inflammation, dermatological conditions, osteoporosis, cancers, secondary hyperparathyroidism, and autoimmune diseases (Corbett et al, 2006;Norman, 2008). These efforts have led to the development of VDR ligands for the treatment of psoriasis, secondary hyperparathyroidism, and osteoporosis (Nagpal et al, 2005).…”

Section: B Vitamin D Receptor Functionmentioning

confidence: 99%

Nuclear Receptors and Their Selective Pharmacologic Modulators

et al. 2013

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“…1 Synthesis of vitamin D and its effects on reproduction and pregnancy. D3 cholecalciferol, GDM gestational diabetes, PCOS polycystic ovarian syndrome, SAB spontaneous abortion, VDR vitamin D receptor reproductive tract; namely, the testis, epididymis, prostate, and seminal vesicles [11][12][13], as well as in human sperm [14,15]. Results have been mixed with respect to VDR expression and semen quality.…”

Section: Male Reproductionmentioning

confidence: 99%

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

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Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

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Vitamin D receptor found in human sperm

Cited by 89 publications

References 13 publications

Vitamin D metabolism, sex hormones, and male reproductive function

Vitamin D metabolism, sex hormones, and male reproductive function

Nuclear Receptors and Their Selective Pharmacologic Modulators

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

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