Vitamin D, muscle and bone: Integrating effects in development, aging and injury

Girgis, Christian M.; Baldock, Paul A.; Downes, Michael

doi:10.1016/j.mce.2015.03.020

Cited by 52 publications

(37 citation statements)

References 138 publications

(185 reference statements)

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“…The anti-inflammatory action may be supported by vitamin D3 (25-hydroxyvitamin D (25-OH-D) due to protection against muscle degradation it provides (Girgis et al 2015). Vitamin D deficiency, however, is a long recognized problem of civilization (Lips 2001).…”

Section: Introductionmentioning

confidence: 99%

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

et al. 2017

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Mechanisms underpinning age-related decreases in muscle strength and muscle mass relate to chronic inflammation. Physical activity induces an anti-inflammatory effect, but it is modulated by additional factors. We hypothesized that vitamin D, which has also anti-inflammatory activity will modify adaptation to exercise and reduce inflammation in elderly women. Twenty-seven women aged 67 ± 8 years were included and divided into groups with baseline vitamin D concentration more than 20 ng mL−1 (MVD) and less than 20 ng mL−1 (LVD). Both groups performed 1 h Nordic Walking (NW) training combined with vitamin D supplementation for 12 weeks. Serum concentrations of inflammation markers, branched amino acids, vitamin D, muscle strength and balance were assessed at the baseline and three days after intervention. The training caused the significant decrease in concentration of pro-inflammatory proteins HMGB1 (30 ± 156%; 90% CI) and IL-6 (−10 ± 66%; 90% CI) in MVD group. This effects in group MVD were moderate, indicating vitamin D as one of the modifiers of these exercise-induced changes. Rise of myokine irisin induced by exercise correlated inversely with HMGB1 and the correlation was more pronounced at the baseline as well as after training among MVD participants. Although the intervention caused the leucine level to rise, a comparison of the recorded response between groups and the adjusted effect indicated that the effect was 20% lower in the LVD group. Overall the applied training program was effective in reducing HMGB1 concentration. This drop was accompanied by the rise of myokine irisin and better uptake of leucine among women with higher baseline vitamin D.

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Section: Introductionmentioning

confidence: 99%

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

et al. 2017

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“…The causes of age‐associated muscle disease (i.e. sarcopenia) are multifactorial and include biological and environmental factors . Skeletal muscle cell apoptosis associated with various injuries has been shown to contribute to muscle remodelling and fibrosis in aged animals and humans .…”

Section: Introductionmentioning

confidence: 99%

“…sarcopenia) are multifactorial and include biological and environmental factors. [1][2][3] Skeletal muscle cell apoptosis associated with various injuries has been shown to contribute to muscle remodelling and fibrosis in aged animals and humans. 3 The pathogenesis of injury-associated skeletal muscle disorder involves extensive extracellular matrix (ECM) remodelling, which requires the participation of extracellular proteases.…”

Section: Introductionmentioning

confidence: 99%

Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice

Ogasawara

Cheng

Inoue

et al. 2017

J cachexia sarcopenia muscle

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BackgroundCathepsin K (CatK) is a widely expressed cysteine protease that has gained attention because of its enzymatic and non‐enzymatic functions in signalling. Here, we examined whether CatK‐deficiency (CatK−/−) would mitigate injury‐related skeletal muscle remodelling and fibrosis in mice, with a special focus on inflammation and muscle cell apoptosis.MethodsCardiotoxin (CTX, 20 μM/200 μL) was injected into the left gastrocnemius muscle of male wild‐type (CatK+/+) and CatK−/− mice, and the mice were processed for morphological and biochemical studies.ResultsOn post‐injection Day 14, CatK deletion ameliorated muscle interstitial fibrosis and remodelling and performance. At an early time point (Day 3), CatK−/− reduced the lesion macrophage and leucocyte contents and cell apoptosis, the mRNA levels of monocyte chemoattractant protein‐1, toll‐like receptor‐2 and toll‐like receptor‐4, and the gelatinolytic activity related to matrix metalloproteinase‐2/‐9. CatK deletion also restored the protein levels of caspase‐3 and cleaved caspase‐8 and the ratio of the BAX to the Bcl‐2. Moreover, CatK deficiency protected muscle fibre laminin and desmin disorder in response to CTX injury. These beneficial muscle effects were mimicked by CatK‐specific inhibitor treatment. In vitro experiments demonstrated that pharmacological CatK inhibition reduced the apoptosis of C2C12 mouse myoblasts and the levels of BAX and caspase‐3 proteins induced by CTX.ConclusionsThese results demonstrate that CatK plays an essential role in skeletal muscle loss and fibrosis in response to CTX injury, possibly via a reduction of inflammation and cell apoptosis, suggesting a novel therapeutic strategy for the control of skeletal muscle diseases by regulating CatK activity.

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“…17 Barker ve ark., kas yaralanmasının ardından insanlarda serum kalsidiol seviyelerinde düşüşler görüldüğünü ve bazal D vitamini seviyeleri kas fonksiyonunda daha hızlı iyileşmeyi sağladığını bildirmişlerdir. 52 Sonuç olarak, D vitamini yetersizliği ve eksikliği sporcuları daha fazla yaralanma riski ile karşı karşıya getirmekte ve iyileşme süresinin uzamasına neden olmaktadır. 6 Bu nedenle, D vitamini takviyesi yüksek yoğunluklu egzersize bağlı kas yaralanması, inflamasyon ve ağrıyı azaltabilir.…”

Section: Vi̇tami̇ni̇ Ve Spor Yaralanmalari D Vitamininin Kas Yaralanmaunclassified

Vitamin D and Athletic Performance

Balci¹,

Toktaş²

2020

Turkiye Klinikleri J Sports Sci

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Vitamin D, muscle and bone: Integrating effects in development, aging and injury

Cited by 52 publications

References 138 publications

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women

Cathepsin K activity controls cardiotoxin‐induced skeletal muscle repair in mice

Vitamin D and Athletic Performance

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