Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients

Costa, Denise S.M. Medrado da; Hygino, Joana; Ferreira, Thaís B.; Kasahara, Taissa M.; Barros, Priscila O.; Monteiro, Clarice; Oliveira, A. Lepletier de; Tavares, Felipe Guimarães; Vasconcelos, Cláudia Cristina Ferreira; Alvarenga, Regina; Bento, Cleonice A.M.

doi:10.1016/j.jneuroim.2016.08.005

Cited by 50 publications

(43 citation statements)

References 45 publications

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“…The disorder is related to the presence of both IL-17 þ IFN-γ þ (CD4 þ and CD8 þ ) T cells and IL-17 þ IFN-γ -CD8 þ T cells, but the absorption of vitamin D after supplementation reduced these subsets and increased the percentage of IL-10-secreting conventional (FoxP3 þ CD25 þ CD127 -CD4 þ ) and nonconventional (IL-17 þ ) regulatory-like T cells. 146 Vitamin D modulates the different levels of the T-reg subsets to maintain a tolerogenic and antiinflammatory (or Th2-like) immunity.…”

Section: Role In Acquired and Regulatory Immunitymentioning

confidence: 99%

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Chirumbolo

Bjørklund

Sboarina

et al. 2017

Clinical Therapeutics

103

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Section: Role In Acquired and Regulatory Immunitymentioning

confidence: 99%

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Chirumbolo

Bjørklund

Sboarina

et al. 2017

Clinical Therapeutics

103

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“…This event was associated with elevated IL‐23 production by monocytes from those patients . In the context of autoimmune diseases, IL‐23, IL‐1 β and IL‐6 cytokines, in the absence of transforming growth factor‐ β , favours pathogenic Th17 differentiation . Although we did not measure transforming growth factor‐ β and IL‐23, higher levels of IL‐1 β and IL‐6, as well as IL‐17 were detected in the plasma of CHC patients than in the control group.…”

Section: Discussionmentioning

confidence: 72%

“…Typically, Th17 cells produce IL‐17, IL‐21 and IL‐22 . However, IL‐6 or IFN‐ γ , and even IL‐10, can be produced by IL‐17‐secreting CD4 + T cells . In addition, IL‐17‐producing CD8 + T cells, called Tc‐17 cells, have also been found in humans …”

Section: Discussionmentioning

confidence: 99%

“…Finally, a higher percentage of IL‐10‐secreting Th17 cells was observed in those patients with lower hepatic lesions. In humans, IL‐10‐secreting Th17 subsets have been associated with tissue protection during inflammatory reactions following viral infection and autoimmune response, suggesting a protective role for these non‐classical regulatory T cells in liver disease in chronically HCV‐infected subjects.…”

Section: Discussionmentioning

confidence: 99%

“…34 However, IL-6 or IFN-c, and even IL-10, can be produced by IL-17-secreting CD4 + T cells. 33,[35][36][37] In addition, IL-17-producing CD8 + T cells, called Tc-17 cells, have also been found in humans. 38 In the early stages of the disease, for example, the production of IL-21 by Th17 cells has been convincingly linked to protection and spontaneous healing after the acute phase of HCV infection.…”

Section: Discussionmentioning

confidence: 99%

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The proportion of different interleukin‐17‐producing T‐cell subsets is associated with liver fibrosis in chronic hepatitis C

et al. 2017

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Studies have suggested the pivotal role of T helper type 1 (Th1) -related cytokines on the outcome of hepatitis C virus (HCV) infection. Nevertheless, the role of different interleukin-17 (IL-17) -secreting T cells on chronic hepatitis C (CHC) is less clear. Here, the in vivo IL-1β, IL-6, and IL-17 levels were positively correlated with both alanine transaminase (ALT) levels and hepatic lesions. When compared with the control group, CHC patients showed a lower proportion of IL-17-secreting (CD4 and CD8 ) T cells capable of simultaneously producing IL-21. Moreover, the percentage of IL-10-secreting Th17 cells was also lower in CHC patients. Notably, advanced liver lesions were observed among those patients with lower percentage levels of IL-17-producing T cells positive for IL-21, interferon-γ (IFN-γ) and IL-10. In contrast, the severity of hepatic damage was associated with peripheral single IL-17 T cells. The percentage of IL-17 IL-21 IFN-γ (CD4 and CD8 ) T-cell phenotypes was positively associated with plasma CD14 levels. Finally, elevated levels of circulating CD14 were detected among CHC patients with extensive liver damage. In summary, although preliminary, our results suggest that a balance between different IL-17-producing T cells, associated with peripheral levels of CD14, may be a progress marker for liver disease in chronically HCV-infected patients.

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Regulation of Dendritic Cell Functions by Vitamins as Promising Therapeutic Strategy for Immune System Disorders

Ghahramanipour,

Alipour,

Masoumi

et al. 2023

Advanced Biology

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A functional immune system is crucial for a healthy life, protecting from infections, tumors, or autoimmune disorders; these are accomplished by the interaction between various immune cells. Nourishment, particularly micronutrients, are very important components in the immune system balance, therefore this review emphasizes the vitamins (D, E, A, C) and Dendritic cells’ subsets due to vitamins’ roles in immune processes, especially on dendritic cells' functions, maturation, and cytokine production. Current studies reveal significant benefits related to vitamins, including vitamin E, which can contribute to the control of dendritic cells’ function and maturation. Furthermore, vitamin D plays an immunoregulatory and anti‐inflammatory role in the immune system. Metabolite of vitamin A which is called retinoic acid leads to T cells’ differentiation to T helper 1 or T helper 17, so low levels of this vitamin exacerbate the menace of infectious diseases, and vitamin C has anti‐oxidant effects on dendritic cells and modulate their activation and differentiation program. Additionally, the correlation between the amount of vitamin and the occurrence or progression of allergic diseases and autoimmunity disorders is discussed according to the results of previous studies.

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Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients

Cited by 50 publications

References 45 publications

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

The proportion of different interleukin‐17‐producing T‐cell subsets is associated with liver fibrosis in chronic hepatitis C

Regulation of Dendritic Cell Functions by Vitamins as Promising Therapeutic Strategy for Immune System Disorders

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