Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line

Inter-dependence of vitamin D levels with serum lipid profiles in multiple sclerosis

“…MS patients have higher levels of markers for lipid peroxidation [41,[48][49][50], which may indicate a higher level of cellular stress from free radicals and reactive oxygen species. Vitamin D may also have effects on lipid peroxidation but contradictory results have been reported from in vitro studies in cultured cells: vitamin D treatment was found to be protective in breast epithelial cells [51] whereas it was found to increase reactive oxygen species in a bone cell line [52].…”

High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells

“…1A, 1B). Moreover, it has been described that dexamethasone-treated muscle cells increase the rate of nonphosphorylative oxygen consumption (31) and that vitamin D 3 increases ROS production (32), which may suggest less efficient ATP production from OXPHOS. Interestingly, tolerogenic moDCs were more affected by etomoxir than oligomycin in terms of ATP production.…”

24,25-Dihydroxyvitamin D3 cooperates with a stable, fluoromethylene LPA receptor agonist to secure human (MG63) osteoblast maturation

“…Despite the wealth of literature reporting on the effects of 1,25D for human osteoblasts (hOBs) only a handful of studies which describe the actions of 24R,25D for these cells have been forthcoming [7][8][9][10][11][12]. What remains to be determined is whether 24R,25D can promote hOB maturation when co-administered with agents known to synergistically co-operate with 1,25D; it is becoming clear that 1,25D often needs to interact with other factors to prosecute the desired response in target cells [13].…”