“…Suffice it to say Met, even as high as 10mM, was unable to evoke any increase in total ALP, either alone or in concert with calcitriol, the active metabolite of D3 vital for securing healthy bone tissue formation [30]. On the contrary, Met actually blunted the ability of D3 and an LPA receptor agonist (FHBP) to induce osteoblast maturation, a robust agent pairing in promoting human osteoblast differentiation [31,32].…”