Vitamin D metabolites 25(OH)D and 1,25(OH)2D and kidney function indices and the relationship to diet in Goeldi's monkeys (Callimico goeldii)

Crissey, Susan D.; Meehan, Thomas P.; Langman, Craig B.; Pruett-Jones, M. A.

doi:10.1002/(sici)1098-2361(1999)18:6<565::aid-zoo10>3.0.co;2-c

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Free-ranging howler monkeys possessed circulating vitamin D metabolites above the levels for captive spider monkeys (another New World monkey), captive Cercopithecidae, great apes, and humans ( Table 2). The animals in this study had higher concentrations of both vitamin D metabolites compared to those reported for captive Callimico goeldii (2171.4, 25(OH)D and 14178.7, 1,25(OH) 2 D) [Crissey et al, 1999a]. However, renal dysfunction may have affected the values in that study.…”

Section: Vitamin Dcontrasting

confidence: 62%

“…Total cholesterol, triacylglyceride, and LDL-cholesterol for this population of howlers were within the range for humans and most captive nonhuman primates, but lower than values reported for captive spider monkeys (Ateles geoffroyi), and higher than reported for captive Callitrichidae [Crissey et al, 1999a;Hainsey et al, 1993;Loeb and Quimby, 1989]. Howler HDL-cholesterol levels were near or within ranges for humans and nonhuman primates, but higher than for captive Callitrichidae (Table 2).…”

Section: Lipidsmentioning

confidence: 48%

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Nutritional status of free‐ranging Mexican howler monkeys (Alouatta palliata mexicana) in Veracruz, Mexico: Serum chemistry; lipoprotein profile; vitamins D, A, and E; carotenoids; and minerals

Crissey¹,

Serio-Silva²,

Meehan³

et al. 2003

Zoo Biology

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(16.571.64 mg/dl) were similar to those in captive spider monkeys (Ateles geoffroyi). Retinyl palmitate and retinyl stearate was present in howler samples and may have reflected recent dietary intake. Circulating a-tocopherol (997797.6 mg/dl) was similar to published values for other primates. Carotenoid levels in howlers were within the ranges reported for many primates. A significant finding was the presence of cadmium in samples that should be further studied. The number of individuals sampled was limited, and further investigation into the effects of seasonality is needed. However, this information provides new data for howler monkeys and for free-ranging primates in general.

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Section: Vitamin Dcontrasting

confidence: 62%

Section: Lipidsmentioning

confidence: 48%

Nutritional status of free‐ranging Mexican howler monkeys (Alouatta palliata mexicana) in Veracruz, Mexico: Serum chemistry; lipoprotein profile; vitamins D, A, and E; carotenoids; and minerals

Crissey¹,

Serio-Silva²,

Meehan³

et al. 2003

Zoo Biology

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“…Most New World primates have been reported to have extremely high levels of circulating vitamin D 3 metabolites in both the 25(OH)D 3 and 1,25(OH) 2 D 3 forms with levels two to 10 times higher than those found in Old World primates and humans ([Adams et al, ; Crissey et al, ; Gacad et al, ] with the exception of Callimico). Several species of New World primates have a high expression of competitive binding proteins intracellular that bind to the vitamin D metabolites and require elevated levels of both 1,25(OH) 2 D 3 for activation of cells and 25(OH)D 3 as the substrate for 1,25(OH) 2 D 3 production [Adams et al, ; Liberman et al, ; Teixeira et al, ].…”

Section: Discussionmentioning

confidence: 99%

“…Reported values of 25(OH)D 2&3 and 1,25(OH) 2 D 2&3 for nonhuman primates generally are higher than human values [Shinki et al, ]. Most New World primate levels reported are 2–10 fold higher than Old World monkeys (Adams et al []; but see Crissey et al [] for lower values in Callimico goeldii ) probably due to high expression of intracellular vitamin D binding proteins and concurrent high baseline levels of 1,25(OH) 2 D 3 . Additionally New World monkeys cannot utilize vitamin D 2 and rely solely on vitamin D 3 [Marx et al, ].…”

Section: Introductionmentioning

confidence: 99%

Measurement of 25‐hydroxyvitamin D_2&3 and 1,25‐dihydroxyvitamin D_2&3 by tandem mass spectrometry: A primate multispecies comparison

Ziegler

Kapoor

Hedman

et al. 2015

American J Primatol

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Vitamin D metabolites are widely studied for their roles in bone health, immune functions and other potential physiologic roles in humans. However, the optimal blood levels of vitamin D metabolites are still unclear. Various methods for measuring vitamin D metabolites have been used and recently liquid chromatography tandem mass spectroscopy (LC-MS/MS) has been adopted as the gold standard for vitamin D metabolite measurement. Here we report the use of LC-MS/MS to measure 25-hydroxyvitamin D (25(OH)D2&3), and 1,25-dihydroxyvitamin D (1,25(OH)2D2&3), in three laboratory nonhuman primate species: common marmoset (Callithrix jacchus), rhesus macaque (Macaca mulatta), and cynomolgus macaque (Macaca fascicularis), and compare them to humans using the same technique. The nonhuman primates showed blood levels for 25(OH)D3 and 1,25(OH)2D3 significantly higher than human values with marmosets having the highest levels. Marmoset samples showed significantly more variability among individuals than those from macaques for both metabolites, but all three nonhuman primate species exhibited large variation within species for both 25(OH)D2&3 and 1,25(OH)2D2&3. Marmoset females had significantly lower values than the males for 25(OH)D3, while rhesus males showed a significant decrease in 25(OH)D3 with age. The most striking finding is the variation within species for vitamin D levels even in laboratory primates that have a controlled diet, UV exposure, and in some cases, genetic constraints. Similar variation in 25(OH)D responses to a fixed dose of oral vitamin D supplementation has been reported in humans. We suggest that these species can provide primate models for examining the factors influencing variation in the levels of vitamin D necessary for human and nonhuman primate health.

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EVALUATION OF IN-HOUSE URINE DIPSTICK, REFERENCE LABORATORY URINALYSIS, AND URINE PROTEIN: CREATININE RATIO FROM A COLONY OF CALLIMICOS (CALLIMICO GOELDII)

Cannizzo

Langan

Warneke

et al. 2016

Journal of Zoo and Wildlife Medicine

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This study evaluated results from an in-house (IH) laboratory dipstick, a reference laboratory (RL) urinalysis, and urine protein : creatinine (UPC) ratios from callimicos ( Callimico goeldii ). Urine was collected from 25 individuals comprising a single colony under professional care in North America and compared based on laboratory, sex, age class, and presence or absence of a normal urinalysis. Urine specific gravity and pH between laboratories were statistically different. Overall, 56% to 100% of animals had at least a trace amount of protein in their urine. In comparing normal and abnormal urinalyses, IH dipstick protein, RL dipstick protein, RL pH, quantitative protein measurement, and UPC ratios were all statistically different. Eleven animals (44%) had UPC ratios that were ≥0.5. Based on results of this study, UPC > 0.3 was found to be abnormal and supportive of renal compromise in callimicos. Higher protein concentrations on the IH dipstick, the quantitative protein concentration, and UPC ratio in the 1- to 4-yr-old age class were the only significant age-related differences. There was no association between any categorical variable (glucose, blood, bilirubin, ketones, urobilinogen) and abnormal urinalysis. There were no differences between sexes. Since renal disease is a major cause of morbidity and mortality in this species, the authors recommend including routine urinalyses and UPC ratios as part of preventive care programs for callimicos. These data provide the first published information on urinalysis and UPC ratios in callimicos and will serve as a helpful reference for interpreting results and evaluating patients with renal disease.

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Vitamin D metabolites 25(OH)D and 1,25(OH)2D and kidney function indices and the relationship to diet in Goeldi's monkeys (Callimico goeldii)

Abstract: keys, 3) although dietary vitamin D did not cause the renal problems, the renal dysfunction may have influenced the vitamin D metabolites.

Cited by 7 publications

References 16 publications

Nutritional status of free‐ranging Mexican howler monkeys (Alouatta palliata mexicana) in Veracruz, Mexico: Serum chemistry; lipoprotein profile; vitamins D, A, and E; carotenoids; and minerals

Nutritional status of free‐ranging Mexican howler monkeys (Alouatta palliata mexicana) in Veracruz, Mexico: Serum chemistry; lipoprotein profile; vitamins D, A, and E; carotenoids; and minerals

Measurement of 25‐hydroxyvitamin D_2&3 and 1,25‐dihydroxyvitamin D_2&3 by tandem mass spectrometry: A primate multispecies comparison

EVALUATION OF IN-HOUSE URINE DIPSTICK, REFERENCE LABORATORY URINALYSIS, AND URINE PROTEIN: CREATININE RATIO FROM A COLONY OF CALLIMICOS (CALLIMICO GOELDII)

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Vitamin D metabolites 25(OH)D and 1,25(OH)2D and kidney function indices and the relationship to diet in Goeldi's monkeys (Callimico goeldii)

Abstract: keys, 3) although dietary vitamin D did not cause the renal problems, the renal dysfunction may have influenced the vitamin D metabolites.

Cited by 7 publications

References 16 publications

Nutritional status of free‐ranging Mexican howler monkeys (Alouatta palliata mexicana) in Veracruz, Mexico: Serum chemistry; lipoprotein profile; vitamins D, A, and E; carotenoids; and minerals

Nutritional status of free‐ranging Mexican howler monkeys (Alouatta palliata mexicana) in Veracruz, Mexico: Serum chemistry; lipoprotein profile; vitamins D, A, and E; carotenoids; and minerals

Measurement of 25‐hydroxyvitamin D2&3 and 1,25‐dihydroxyvitamin D2&3 by tandem mass spectrometry: A primate multispecies comparison

EVALUATION OF IN-HOUSE URINE DIPSTICK, REFERENCE LABORATORY URINALYSIS, AND URINE PROTEIN: CREATININE RATIO FROM A COLONY OF CALLIMICOS (CALLIMICO GOELDII)

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Measurement of 25‐hydroxyvitamin D_2&3 and 1,25‐dihydroxyvitamin D_2&3 by tandem mass spectrometry: A primate multispecies comparison