Vitamin D, low birthweight preterm and full-term newborns: time for a paradigm shift

Захарова, И. Н.; Мальцев, С В; Зубков, В. В.; Kur’yaninova, Viktoriya; Dmitriev, Aleksandr; Malyavskaya, S. I.; Maltseva, L. I.; Verisokina, N.E.; Klimov, Leonid; Васильева, Э Н; Krushel’nitskiy, A.A.; Makhaeva, A.V.; Zhdakaeva, E.D.; Zaplatnikov, A.L.

doi:10.32364/2618-8430-2020-3-2-142-148

Cited by 5 publications

(3 citation statements)

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“…Ya., Kuryaninova V. A., Atanesyan R. A., Kirienko Given the steadily increasing survival rate of premature babies, who are more likely to develop skeletal abnormalities, diagnosing vitamin D deficiency-related diseases is essential. Newborns, including preterm infants, constitute a high-risk group for developing 25(OH)D deficiency [2][3][4].…”

Section: ключевые слова: костная ткань костный метаболизм новорожденн...mentioning

confidence: 99%

The significance of vitamin D in the regulation of bone metabolism in term and premature infants

Petrosyan¹,

Verisokina²,

Klimov³

et al. 2023

Medical news of the North Caucasus

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Improvements in neonatal care for premature babies have led to significant improvements in survival rates for low and very low birth weight infants. Due to the characteristics of calcium-phosphorus homeostasis and bone metabolism, neonatologists often encounter skeletal system pathology in premature newborns. This condition is a metabolic disease of premature infants' bones based on a deficiency of calcium, phosphorus, and vitamin D, resulting in impaired growth and mineralization of the growing skeleton. Vitamin D is one of the most important regulators of bone metabolism. On the one hand, it stimulates the absorption of Ca2+ and P3-in the small intestine, and on the other hand, it has a direct effect on bone tissue cells (osteoblasts, osteocytes, osteoclasts, and chondrocytes) through the vitamin D receptors located in them. Risk factors for developing bone metabolism disorders in term and premature newborns, as well as the correlating role of vitamin D in skeletal formation and maintaining homeostasis, were considered.

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Section: ключевые слова: костная ткань костный метаболизм новорожденн...mentioning

confidence: 99%

The significance of vitamin D in the regulation of bone metabolism in term and premature infants

Petrosyan¹,

Verisokina²,

Klimov³

et al. 2023

Medical news of the North Caucasus

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“…The persistence of hypercalciuria throughout the neonatal period was revealed in preterm infants up to 32 weeks of gestation. An insufficient level of vitamin D contributes to impaired absorption of Ca 2+ in the intestine and the development of hypocalcemia [10].…”

Section: Fig 2 Metabolism and The Role Of Vitamin Dmentioning

confidence: 99%

“…According to the results of numerous studies, vitamin D deficiency increases the risk of metabolic disorders, diseases of the endocrine, immune, cardiovascular, reproductive and other systems (Fig. 2) [10,11]. One of the most susceptible to hypovitaminosis D population groups are newborns, regardless of gestational age [12].…”

mentioning

confidence: 99%

Hypovitaminosis D and osteopenia of preterm infants: risk factors and mechanisms of formation

Klimov¹,

Petrosyan²,

Verisokina³

et al. 2021

Medical news of the North Caucasus

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The article presents a literature review on the effect of vitamin D deficiency on the body of premature newborns. According to the results of numerous studies, insufficient intake of vitamin D in the fetus increases the risk of developing bronchopulmonary dysplasia, lower respiratory tract infections, and neonatal sepsis. There is evidence that hypovitaminosis D negatively affects physical and neuropsychic development. One of the most important biological effects of vitamin D, namely its participation in the regulation of phosphorus-calcium metabolism and bone remodeling, is discussed. The mechanisms of the influence of parathyroid hormone (PTH) and calcitonin (CT) on the regulation of phosphorus-calcium homeostasis are also described. Increasing the survival rate of extremely low birth weight and very low birth weight infants increases the incidence of pediatricians and neonatologists with diseases such as osteopenia -a metabolic bone disease of preterm infants, characterized by impaired bone mineralization due to a lack of vitamin D, calcium and phosphorus. The review examines the causes, clinical manifestations, diagnosis, treatment and prevention of this disease.

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Analysis of vitamin D availability of premature infants in the south of Russia

Verisokina

Kuryaninova²,

Petrosyan

et al. 2022

Medicinskij sovet

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Introduction. Inadequate vitamin D supply worldwide is a public health problem. Low vitamin D levels during pregnancy can lead to abnormal placentation, placental insufficiency and abnormal fetal development, which contributes to poor health after birth.Objective of the study is to analyze the vitamin D status of premature infants born in the south of Russia.Materials and methods. A total of 141 premature infants were examined. Extremely low birth weight was found in 19 (13.4%) newborns, very low birth weight in 35 (24.8%), and low birth weight in 75 (53.2%).Results and discussion. Premature infants had vitamin D deficiency in the majority of cases (51%), with a median of 16.9 [11.7; 22.9] ng/mL. Correlation analysis demonstrated a positive association between 25(OH)D levels and body weight in very low birth weight infants (r = 0.34, p = 0.043). Serum vitamin D concentrations were 1.6 times lower in infants whose mothers did not receive multivitamins than in those whose mothers received multivitamins, 13.8 [9.7; 20.9] and 21.6 [16.9; 28.6] ng/mL, respectively (p = 0.001). Infants with an Apgar score of 7-10 had higher vitamin D levels, 17.8 [11.9; 22.7] ng/mL, than infants with severe asphyxia, 13.8 [9.9; 16.8] ng/mL (p = 0.036). Premature infants with congenital infection had lower 25(OH)D levels than infants without an infectious process, 15.6 [10.8; 22.9] and 18.4 [14.2; 22.7] ng/mL, respectively. Children with an infectious process that subsequently ended in death had lower 25(OH)D levels than children without an infectious process (p = 0.001). Children with cerebral ischemia had lower 25(OH)D concentrations than children without cerebral ischemia (p = 0.001).Conclusions. Premature infants born in the south of Russia have vitamin D deficiency in more than half of the cases. Administration of preparations containing cholecalciferol reduces the proportion of newborns with severe vitamin D deficiency, but does not ensure optimal serum levels. Initially low levels of 25(OH)D can be considered as an unfavorable prognostic sign against the background of the development of congenital infection.

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Vitamin D, low birthweight preterm and full-term newborns: time for a paradigm shift

Cited by 5 publications

References 0 publications

The significance of vitamin D in the regulation of bone metabolism in term and premature infants

The significance of vitamin D in the regulation of bone metabolism in term and premature infants

Hypovitaminosis D and osteopenia of preterm infants: risk factors and mechanisms of formation

Analysis of vitamin D availability of premature infants in the south of Russia

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