Vitamin D levels predict hospitalization and mortality in patients with heart failure

Belen, Erdal; Sungur, Aylin; Sungur, Mustafa Azmi

doi:10.3109/14017431.2015.1098725

Cited by 13 publications

(10 citation statements)

References 27 publications

(27 reference statements)

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“…After adjusting for multiple confounders, the outcome data from the cohort study are consistent with previous smaller reports in ambulatory patients [9,21,22], hospitalised patients [10] and registry data [3,6,23], and reveal increased mortality in patients with low 25[OH]D concentrations compared with those without. In all of these previous studies, 25[OH]D deficiency was less frequent than in our cohort ranging from 28 to 75% [10,24], whilst overall mortality of the cohorts was higher.…”

Section: Discussionsupporting

confidence: 79%

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure

et al. 2018

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Section: Discussionsupporting

confidence: 79%

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure

et al. 2018

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“…A significant high prevalence of vitamin D deficiency in patients with HF, when comparing low and very low vs. normal serum 25(OH)D levels (HR = 1.33 and 2.19, respectively), has been found [31]. A high prevalence of vitamin D deficiency among patients with HF and an independent association of low 25(OH)D levels with hospitalization and mortality rates have also been described [32]. On the other hand, in a different type of study to evaluate whether inadequate serum levels of 25(OH)D predict the prevalence of chronic conditions such as cardiovascular disease, type 2 diabetes, and obesity, among others, no association with any chronic condition, including heart failure, was found; this study did not report prevalence of vitamin D deficiency [33].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Vitamin D with Inflammatory Cytokines, Atherosclerotic Parameters, and Lifestyle Factors in the Setting of Heart Failure: A 12-Month Follow-Up Study

Roffe-Vazquez

Delgado

Castillo

et al. 2019

IJMS

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Vitamin D deficiency is highly prevalent worldwide. It has been associated with heart failure (HF) given its immunoregulatory functions. In-vitro and animal models have shown protective roles through mechanisms involving procollagen-1, JNK2, calcineurin/NFAT, NF-κB, MAPK, Th1, Th2, Th17, cytokines, cholesterol-efflux, oxLDL, and GLUT4, among others. A 12-month follow-up in HF patients showed a high prevalence of vitamin D deficiency, with no seasonal variation (64.7–82.4%). A positive correlation between serum 25(OH)D concentration and dietary intake of vitamin D-rich foods was found. A significant inverse correlation with IL-1β (R = −0.78), TNF-α (R = −0.53), IL-6 (R = −0.42), IL-8 (R = −0.41), IL-17A (R = −0.31), LDL-cholesterol (R = −0.51), Apo-B (R = −0.57), total-cholesterol (R = –0.48), and triglycerides (R = −0.32) was shown. Cluster analysis demonstrated that patients from cluster three, with the lowest 25(OH)D levels, presented the lowermost vitamin D intake, IL-10 (1.0 ± 0.9 pg/mL), and IL-12p70 (0.5 ± 0.4 pg/mL), but the highest TNF-α (9.1 ± 3.5 pg/mL), IL-8 (55.6 ± 117.1 pg/mL), IL-17A (3.5 ± 2.0 pg/mL), total-cholesterol (193.9 ± 61.4 mg/dL), LDL-cholesterol (127.7 ± 58.2 mg/dL), and Apo-B (101.4 ± 33.4 mg/dL) levels, compared with patients from cluster one. Although the role of vitamin D in the pathogenesis of HF in humans is still uncertain, we applied the molecular mechanisms of in-vitro and animal models to explain our findings. Vitamin D deficiency might contribute to inflammation, remodeling, fibrosis, and atherosclerosis in patients with HF.

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“…In the same way, obese people are more prone to vitamin D deficiency, both obesity and vitamin D deficiency were independent risk factors for heart failure [ 44 ]. Another well-organized RCT from 2016 examined the role of vitamin D in predicting the rate of hospitalizations and mortality in HF patients [ 45 ]. This study finally concluded vitamin D as an independent predictor of hospitalizations and the risk of mortality [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

“…Another well-organized RCT from 2016 examined the role of vitamin D in predicting the rate of hospitalizations and mortality in HF patients [ 45 ]. This study finally concluded vitamin D as an independent predictor of hospitalizations and the risk of mortality [ 45 ]. The limitations of this study were the small sample size and small control group.…”

Section: Reviewmentioning

confidence: 99%

Role of Vitamin D Supplementation in Heart Failure Patients With Vitamin D Deficiency and Its Effects on Clinical Outcomes: A Literature Review

Busa

Dardeir

Marudhai

et al. 2020

Cureus

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Vitamin D deficiency has become a global pandemic affecting approximately one billion people worldwide. Much attention has been paid to the association of low serum 25-hydroxyvitamin D (25(OH)D) levels and various chronic diseases, especially heart failure (HF). A clear role of vitamin D deficiency has been established, with increased mortality and morbidity in heart failures. However, previous randomized control trials have failed to show improvement in clinical outcomes with calciferol supplementation in these patients. Therefore, it is still unclear whether calciferol therapy can be added to the standard care in congestive heart failure (CHF) patients with deficiency. Hence, to evaluate the role of vitamin D supplementation in CHF patients with low serum 25(OH)D, we conducted an extensive search in the PubMed and Google Scholar databases using various combinations of keywords. All potentially eligible studies that evaluated the effects of vitamin D supplementation on clinical outcomes in HF patients were retrieved and extensively studied. We also checked the references of all eligible studies to identify additional relevant publications. In this study, we reviewed various mechanisms of vitamin D affecting the cardiovascular system and examined the impact of deficiency on heart failures in terms of mortality and hospitalizations. In conclusion, vitamin D supplementation has failed to improve the clinical outcomes in HF patients. The possible long-term benefits of supplementation cannot be excluded. Therefore, for future clinical trials, we recommend considering large sample sizes, longer follow-up durations, along with optimal dosage and appropriate dosing frequency.

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Vitamin D levels predict hospitalization and mortality in patients with heart failure

Abstract: Vitamin D deficiency is highly prevalent in patients with HF, and low vitamin D levels are closely associated with increased hospitalisation and mortality.

Cited by 13 publications

References 27 publications

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure

Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure

Correlation of Vitamin D with Inflammatory Cytokines, Atherosclerotic Parameters, and Lifestyle Factors in the Setting of Heart Failure: A 12-Month Follow-Up Study

Role of Vitamin D Supplementation in Heart Failure Patients With Vitamin D Deficiency and Its Effects on Clinical Outcomes: A Literature Review

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