Vitamin D Levels in Patients with Type 2 Diabetes Mellitus

Calvo-Romero, José Marı́a; Ramiro-Lozano, José Manuel

doi:10.1097/jim.0000000000000234

Cited by 23 publications

(18 citation statements)

References 17 publications

(36 reference statements)

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“…The discrepancy between the findings of epidemiologic surveys and intervention studies regarding Vitamin D and type 2 diabetes is remarkable. Most cross-sectional studies found a revers relationship between 25(OH)D serum concentrations and type 2 diabetes[ 9 20 21 22 ] while others revealed an independent inverse association only in women. [ 23 24 25 ] One meta-analysis including twenty-one prospective studies showed that there was inverse association between serum 25(OH)D levels and incidence of type 2 diabetes after adjusting for BMI and intermediate biomarkers (included 4996 incident cases of diabetes and 76220 nondiabetic controls).…”

Section: Discussionmentioning

confidence: 99%

“…[ 16 ] However, in studies examining prediabetic patients, improvement in HbA1c and FPG in Vitamin D receiving groups bordered on statistical significance. [ 21 ] Possible explanation for lack of an effect found in intervention studies might be related to the patient characteristic, duration of the study, dosage, and other confounding variables.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients

et al. 2017

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Background:The aim of the current trial was to investigate the effect of Vitamin D treatment on metabolic markers in people with Vitamin D deficiency and thyroid autoimmunity.Materials and Methods:In this double-blind, randomized, placebo-controlled clinical trial, 65 Vitamin D deficient euthyroid or hypothyroid patients with positive TPO-Ab were enrolled. They randomly allocated into two groups to receive oral Vitamin D3 (50000 IU weekly) and placebo for 12 weeks. Serum concentration of calcium, phosphorus, albumin, C-reactive protein, blood urea nitrogen, creatinine, glycated hemoglobin (HbA1c), insulin, fasting plasma glucose (FPG), triglyceride (TG), total cholesterol, and high-density lipoprotein were measured in both groups before and after the trial. Homeostasis model assessment estimates of beta cell function (HOMA-B) and HOMA-insulin resistance (HOMA-IR) were calculated before and after trial in both groups.Results:Thirty-three and thirty-two participants were allocated to Vitamin D-treated and placebo-treated groups, respectively. Mean (standard error) level of Vitamin D increased significantly in Vitamin D-treated group (45.53 [1.84] ng/mL vs. 12.76 [0.74] ng/mL, P = 0.001). The mean of HbA1c and insulin was increased significantly both in Vitamin D-treated and placebo-treated groups (P < 0.05). Other variables did not meet a significant change after trial (P = NS). In between-group comparison, there was not any significant difference between Vitamin D-treated and placebo-treated groups regarding measures of HOMA-B, HOMA-IR, FPG, HbA1c, and TG (P = NS).Conclusion:Our findings showed that weekly 50000 IU oral Vitamin D3 for 12 weeks did not improve metabolic markers, IR, or insulin secretion in Vitamin D deficient patients with Hashimoto thyroiditis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients

et al. 2017

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“…Wenzhou, which is a southeastern coastal city of China, is in temperate zones (23.5°–66.5°). It has been reported that vitamin D deficiency was independently correlated with T2D, due to increased insulin resistance and β-cell malfunction [ 22 , 23 ]. Although 25(OH)D deficiency is usually detected in T2D patients, especially in those who are obese and in which insulin resistance is the most common finding, nutritional status of hypovitaminosis D was widely observed in non-obese diabetes by our pilot study.…”

Section: Discussionmentioning

confidence: 99%

Association Between 25-Hydroxyvitamin D and Epicardial Adipose Tissue in Chinese Non-Obese Patients with Type 2 Diabetes

Chen

Wang

et al. 2017

Med Sci Monit

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BackgroundEpicardial adipose tissue (EAT) is recognized as a useful indicator for type 2 diabetes mellitus (T2DM) and obesity. However, studies on the association between vitamin D status and EAT thickness in type 2 diabetes (T2D) are limited. In this study, we aimed to evaluate the association of vitamin D (Calcifediol) status and EAT thickness (EATT) in Chinese non-obese patients with T2D.Material/MethodsA cross-sectional study was performed among 167 non-obese T2D Chinese patients and 82 non-diabetic patients, who are age- and gender-matched during the winter months. EATT was evaluated by two-dimensional transthoracic echocardiography. Serum 25-hydroxyvitamin D [25(OH)D, Calcifediol] was examined in the diabetic patients and in the control group.ResultsThe concentration of 25(OH)D was 32.00 nmol/l (19.30–53.70 nmol/l) among diabetic patients. Most (93.4%) of the diabetic patients had hypovitaminosis D. We confirmed a clear negative association between 25(OH)D level and EATT in non-obese T2D patients (p=0.01). EATT was significantly correlated with 25(OH)D level (p=0.001) and HOMA-IR (p=0.001). Results of multivariate logistic regression analysis demonstrated increased EATT, which was remarkably associated with 25(OH)D levels (p=0.039), systolic blood pressure (SBP) (p=0.013), HOMA-IR (p=0.030), and waist circumference (p<0.001) in T2D patients after adjusting for the confounding factors.ConclusionsIncreased EATT was found in Chinese non-obese T2D patients. 25(OH)D and HOMA-IR were independently associated with increased EATT after adjusting for multiple confounders.

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“…Low concentration of vitamin D is associated with T2DM patients. e serum concentration of 1,25(OH)D in 69.9% of 103 patients is lower than 20 ng/ml and negatively correlated with hemoglobin A1C and insulin resistance [105]. In adults aged over 45 years, vitamin D deficiency is significantly associated with occurrence of T2DM [106].…”

Section: Vitamin D Deficiency With Lipidmentioning

confidence: 99%

A Potential Linking between Vitamin D and Adipose Metabolic Disorders

Miao

Wang

et al. 2020

Canadian Journal of Gastroenterology and Hepatology

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Vitamin D has been discovered centuries ago, and current studies have focused on the biological effects of vitamin D on adipogenesis. Besides its role in calcium homeostasis and energy metabolism, vitamin D is also involved in the regulation of development and process of metabolic disorders. Adipose tissue is a major storage depot of vitamin D. This review summarized studies on the relationship between vitamin D and adipogenesis and furthermore focuses on adipose metabolic disorders. We reviewed the biological roles and functionalities of vitamin D, the correlation between vitamin D and adipose tissue, the effect of vitamin D on adipogenesis, and adipose metabolic diseases. Vitamin D is associated with adipogenesis, and vitamin D supplements can reduce the burden caused by metabolic diseases. The review provides new insights and basis for medical therapy on adipose metabolic diseases.

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Vitamin D Levels in Patients with Type 2 Diabetes Mellitus

Cited by 23 publications

References 17 publications

Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients

Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients

Association Between 25-Hydroxyvitamin D and Epicardial Adipose Tissue in Chinese Non-Obese Patients with Type 2 Diabetes

A Potential Linking between Vitamin D and Adipose Metabolic Disorders

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