Vitamin D levels in Jamaican patients with systemic lupus erythematosus

McGhie, TK; DeCeulaer, K; Walters, CA; Soyibo, AK; Mg, Lee

doi:10.1177/0961203314528556

Cited by 18 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distribution of 25-OH VD levels in the Hopkins and Jamaican cohorts were strikingly similar, mean levels in each cohort falling below what is considered the normal reference value of 30ng/ml (18). The observed high prevalence of vitamin D deficiency and insufficiency in these cohorts has been shown in previous studies of both cohorts (12, 19) as well as in other independent studies. It is a common finding that transcends differences in ethnicity (20) and has largely been thought to occur as a result of disease activity limiting nutritional intake and sunlight exposure.…”

Section: Discussionsupporting

confidence: 84%

Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus

Smikle

DeCeulaer

Romay-Penabad³

et al. 2017

Lupus

Self Cite

View full text Add to dashboard Cite

Background The abnormal biological activity of cytokines plays an important role in the pathophysiology of both systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Several studies have highlighted the association of vitamin D and certain pro-inflammatory cytokines with disease activity in SLE. However, there are limited data on the association of vitamin D and antiphospholipid antibodies (aPL) with various proinflammatory biomarkers in these patients and their relative impact on clinical outcomes. Methods The serum levels of several aPL, 25-hydroxy vitamin D, pro-inflammatory cytokines including IFNα, IL-1β, IL-6, IL-8, IP10, sCD40L, TNFα and VEGF were measured in 312 SLE patients from the Jamaican (n-=45) and Hopkins (n=267) Lupus cohorts using commercial Milliplex and ELISA assays. Oxidized LDL/β2glycoprotein antigenic complexes (oxLβ2Ag) and their associated antibodies were also measured in the Jamaican cohort. Healthy controls for oxidative marker and cytokine testing were utilized. Results Abnormally low vitamin D levels were present in 61.4% and 73.3% of Hopkins and Jamaican SLE patients respectively. Median concentrations of IP10, TNFα, sCD40L and VEGF were elevated in both cohorts, oxLβ2Ag and IL-6 were elevated in the Jamaican cohort and IFNα, IL-1β and IL-8 were the same or lower in both cohorts compared to controls. IP10 and VEGF were independent predictors of disease activity, aPL, IP10 and IL-6 were independent predictors of thrombosis and IL-8 and low vitamin D were independent predictors of pregnancy morbidity despite there being no association of vitamin D with pro-inflammatory cytokines. Conclusions Our results indicate that aPL-mediated pro-inflammatory cytokine production is likely a major mechanism of thrombus development in SLE patients. We provide presumptive evidence of the role IL-8 and hypovitaminosis D play in obstetric pathology in SLE but further studies are required to characterize the subtle complexities of vitamin D’s relationship with cytokine production and disease activity in these patients.

show abstract

Section: Discussionsupporting

confidence: 84%

Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus

Smikle

DeCeulaer

Romay-Penabad³

et al. 2017

Lupus

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our findings are consistent with several other observational studies that have shown that vitamin D level inversely correlates with disease activity. 7–9 16 21 22 27–29 In the longitudinal follow-up, univariable analysis showed significant associations of vitamin D with subsequent increases in SLEDAI-2K or high disease activity (SLEDAI-2K >10), each with ORs greater than 3. The predictive effect of low vitamin D on subsequent disease activity did not remain significant after adjustment for vitamin D supplementation, glucocorticoid use and immunosuppressive use, suggesting that in future studies of vitamin D effects in SLE, these variables should be controlled for.…”

Section: Discussionmentioning

confidence: 99%

“… 19 20 The frequency of vitamin D deficiency varies greatly between communities in different latitudes. 7 9 16 21 22 Currently, it is not yet known whether observations made in a certain location are applicable globally. Moreover, knowledge about the impact on SLE of vitamin D supplementation, often given to SLE patients as part of a preventive approach to osteoporosis or in an attempt to treat vitamin D deficiency, is lacking.…”

Section: Introductionmentioning

confidence: 99%

Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort

et al. 2015

View full text Add to dashboard Cite

BackgroundVitamin D status varies with geographic location and no studies of vitamin D in systemic lupus erythematosus (SLE) have been reported in the Southern Hemisphere.ObjectivesTo assess the prevalence of vitamin D deficiency in an Australian SLE cohort, and its relationship with disease activity.MethodsData were collected prospectively on 119 consecutive patients with SLE in the Monash Lupus Clinic in Melbourne, Australia, between January 2007 and January 2013. Patients had simultaneous serum 25-hydroxyvitamin D concentration and disease activity (SLEDAI-2K) recorded. Statistical methods were used to determine the correlation of serum vitamin D level and disease activity both at baseline and at a subsequent time point. Adjustments were made for the use of glucocorticoids, immunosuppressants and vitamin D supplementation.ResultsVitamin D deficiency (<40 nmol/L) was detected in 27.7% of patients at baseline. Multiple regression analysis showed a significant inverse correlation of SLEDAI-2K with baseline vitamin D level and with vitamin D supplementation. Over a 12-month period of observation, among the 119 patients, there were 464 serial vitamin D measurements with corresponding SLEDAI-2K, representing 266 time intervals. The median change in vitamin D level was an increase of 25 nmol/L and this corresponded with a decline in SLEDAI-2K of 2 units. In regression analysis, there was a significant association between low vitamin D at a prior time point and a rise in SLEDAI-2K at the subsequent time point (univariable OR 3.3, 95% CI 1.5 to 7.7, p=0.005) or having a high disease activity (SLEDAI-2k>10) at the subsequent time point (univariable OR 3.1, 95% CI 1.4 to 6.8, p=0.004).ConclusionsIn Australian patients with SLE, low vitamin D was associated with a higher disease activity and an increase in serum vitamin D was associated with reduced disease activity over time. The therapeutic effect of vitamin D in SLE should be further assessed in interventional studies.

show abstract

“…A significantly high prevalence of vitamin D deficiency has been observed in patients with SLE in Saudi Arabia ( 114 ), Bahrain ( 115 ), the USA ( 116 , 117 ), Canada ( 118 ), Jamaica ( 119 ), Brazil ( 120 ), France ( 121 ), Hungary ( 122 ), Denmark ( 123 ), and Spain ( 124 , 125 ). In clinical studies on patients with SLE, significant inverse correlations were observed between serum levels of vitamin D and SLE disease activity index (SLEDAI) score in Malaysian ( 126 ), Taiwanese ( 127 ), Thai ( 128 ), Indian ( 129 ), Egyptian ( 130 , 131 ), Saudi Arabian ( 132 ), Brazilian ( 133 , 134 ), Australian ( 135 ), American ( 136 ), Hungarian ( 122 ), and Chinese ( 137 ) populations with an exception of Serbian SLE subjects ( n = 46) ( 138 ).…”

Section: Micronutrientsmentioning

confidence: 99%

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

et al. 2020

View full text Add to dashboard Cite

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the haematopoietic system, with a large number of complications. Despite years of study, the etiology of SLE remains unclear; thus, safe and specifically targeted therapies are lacking. In the last 20 years, researchers have explored the potential of nutritional factors on SLE and have suggested complementary treatment options through diet. This study systematically reviews and evaluates the clinical and preclinical scientific evidence of diet and dietary supplementation that either alleviate or exacerbate the symptoms of SLE. For this review, a systematic literature search was conducted using PubMed, Scopus and Google Scholar databases only for articles written in the English language. Based on the currently published literature, it was observed that a low-calorie and low-protein diet with high contents of fiber, polyunsaturated fatty acids, vitamins, minerals and polyphenols contain sufficient potential macronutrients and micronutrients to regulate the activity of the overall disease by modulating the inflammation and immune functions of SLE.

show abstract

Vitamin D levels in Jamaican patients with systemic lupus erythematosus

Cited by 18 publications

References 22 publications

Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus

Clinical associations of proinflammatory cytokines, oxidative biomarkers and vitamin D levels in systemic lupus erythematosus

Association of low vitamin D with high disease activity in an Australian systemic lupus erythematosus cohort

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

Contact Info

Product

Resources

About