Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

Islam, Asiful; Khandker, Shahad Saif; Kotyla, Przemysław; Hassan, Rosline

doi:10.3389/fimmu.2020.01477

Cited by 57 publications

(36 citation statements)

References 181 publications

(179 reference statements)

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“…The contents of different minerals significantly increased in FAME, in accordance with the findings of a previous study [ 55 ]. These micronutrients can regulate the overall disease by modulating immune functions and inflammation [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Aronia melanocarpa Extract Fermented by Lactobacillus plantarum EJ2014 Modulates Immune Response in Mice

Ali

Lee

et al. 2021

Antioxidants

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The present study aimed to assess the immunomodulatory effects of fermented Aronia melanocarpa extract (FAME) on RAW 264.7 cells and BALB/c mice. Aronia melanocarpa fruit was fermented with Lactobacillus plantarum EJ2014 by adding yeast extract and monosodium glutamate for 9 days at 30 °C to produce γ-aminobutyric acid (GABA). After fermentation, significant GABA production was noted, along with minerals, polyphenols, and flavonoids (p < 0.05). The polyphenol content was confirmed by liquid chromatography with tandem mass spectrometry (LC–MS/MS) analysis. RAW 264.7 cells were stimulated with lipopolysaccharide (LPS, 1 μg/mL) in the presence or absence of FAME, and proinflammatory cytokine contents were measured by qPCR. In the in vivo experiment, female BALB/c mice were administered 125, 250, and 500 mg/kg of FAME for 21 days. FAME treatment increased neutrophil migration and phagocytosis (p < 0.05). It also increased splenocyte proliferation, CD4+ and CD8+ T-cell expression, and lymphocyte proliferation. Furthermore, it increased IFN-γ, IL-2, and IL-4 cytokine levels in a dose-dependent manner (p < 0.05). However, it decreased TNF-α and IL-6 levels (p < 0.05). These results indicate that FAME fortified with GABA including bioactive compounds exerts anti-inflammatory effects by inhibiting proinflammatory cytokines in RAW 264.7 cells and modulates immune response in mice. Thus, FAME could be a potential therapeutic agent for inflammatory disorders.

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Section: Discussionmentioning

confidence: 99%

Aronia melanocarpa Extract Fermented by Lactobacillus plantarum EJ2014 Modulates Immune Response in Mice

Ali

Lee

et al. 2021

Antioxidants

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“…Medeiros et al [] published a systematic review investigating the effects of nutritional supplements such as omega-3 and vitamin D, as well as the study by Islam et al who recommends intake of Omega 3 and 6; vitamins A, B, C, D, and E; minerals (calcium, zinc, selenium, iron, and copper) and polyphenol-containing foods to produce an immunomodulatory effect in SLE patients [21], differing from the present study because the objective of the latter was to evaluate the nutritional diet impact, not a specific nutritional supplement. Regarding methodological aspects, the review by Medeiros et al [] restricted the search to the period from 2006 to 2016, and the exclusion criteria evaluated nutrients or diet analyses only.…”

Section: Discussionmentioning

confidence: 99%

The impact of a low-calorie, low-glycemic diet on systemic lupus erythematosus: a systematic review

et al. 2021

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Background Diet plays a critical role in Systemic Lupus Erythematosus (SLE) patients, impacting on the microbiota composition and, consequently, on the immune response. The objective was to analyze and verify the diet effect on SLE patients. Methods This is a systematic review performed at the Evidences-based Health Lab, Escola Superior em Ciências da Saúde, Brasília (DF), Brazil. In March, 2021, five databases, and grey literature, through JSTOR, Open Grey, and Google Scholar were searched. Randomized Clinical Trials in which SLE patients with calorie restricted, low glycemic index or other diet involving the joint adequacy of these aspects, compared with placebo or different types of diet, were included. Results It was identified in the databases 758 articles; 132 were duplicated; 616 references were screened, and 604 were excluded. After reading the title and abstract, 12 articles were included for full-text reading. After the full-text reading, three studies were included for quantitative analysis. The diet improved the quality of life at 6 (MD 16.30; 5.91;26.69) and 12 weeks (MD 14.60; 0.88;28.32). The GRADE was used to evaluate the quality of evidence. Conclusion There is low evidence that the diet has a positive impact on the quality of life of SLE patients. Trial registration PROSPERO—CRD4202012208.

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“…Obesity is defined as a body mass index (BMI) over 30 kg/m 2 and corresponds to excessive body fat in the form of adipose tissue. It is now well known that obesity is characterized by a state of chronic low-grade inflammation; that is, obesity induces pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and IL-6 [17]. The connection between obesity and autoimmunity has been vigorously investigated.…”

Section: The Conceivable Link Between Obesity and Slementioning

confidence: 99%

“…The link between diet and the risk of developing autoimmune disorders was proposed half a century ago [16]. In the last two decades, much research has been undertaken with the aim of clarifying the relationships among diet, SLE development, and disease activity [17].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Obesity and a High-Fat Diet on Clinical and Immunological Features in Systemic Lupus Erythematosus

et al. 2021

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multiple organ involvement predominantly affecting women of childbearing age. Environmental factors, as well as genetic predisposition, can cause immunological disturbances that manifest as SLE. A habitual high-fat diet and obesity have recently been reported to play a role in the pathogenesis of autoimmune diseases. The frequency of obesity is higher in patients with SLE than in general populations. Vitamin D and adipokines, such as leptin and adiponectin, are possible mediators connecting obesity and SLE. Serum leptin and adiponectin levels are elevated in patients with SLE and can impact innate and adaptive immunity. Vitamin D deficiency is commonly observed in SLE. Because vitamin D can modulate the functionality of various immune cells, we review vitamin D supplementation and its effects on the course of clinical disease in this work. We also discuss high-fat diets coinciding with alterations of the gut microbiome, or dysbiosis. Contingent upon dietary habits, microbiota can be conducive to the maintenance of immune homeostasis. A high-fat diet can give rise to dysbiosis, and patients who are affected by obesity and/or have SLE possess less diverse microbiota. Interestingly, a hypothesis about dysbiosis and the development of SLE has been suggested and reviewed here.

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Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

Cited by 57 publications

References 181 publications

Aronia melanocarpa Extract Fermented by Lactobacillus plantarum EJ2014 Modulates Immune Response in Mice

Aronia melanocarpa Extract Fermented by Lactobacillus plantarum EJ2014 Modulates Immune Response in Mice

The impact of a low-calorie, low-glycemic diet on systemic lupus erythematosus: a systematic review

The Impact of Obesity and a High-Fat Diet on Clinical and Immunological Features in Systemic Lupus Erythematosus

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