Vitamin D Level in Patients with Consecutive Acute Coronary Syndrome Is Not Correlated with the Parameters of Platelet Activity

Abstract

Coronary artery disease continues to be the leading cause of death in developed countries. Elevated mean platelet volume (MPV) is associated with an increased incidence of myocardial infarction (MI) and MI-related mortality. Vitamin D concentrations affect the level and function of platelets, which are the crucial mediator of atherothrombosis and plaque rupture. The main aim of this study was to examine the relationship of serum 25-hydroxyvitamin D (25(OH)D) levels with the platelet activity in patients with a history of an acute coronary syndrome (ACS). This prospective study recruited 268 patients with a history of MI who underwent coronary angiography due to the suspicion of another ACS. Serum 25(OH)D concentration was determined by electrochemiluminescence. Platelet activity was assessed using the MPV and platelet-large cell ratio (P-LCR) parameters. There was no significant difference in MPV and P-LCR values between patients diagnosed with subsequent MI and patients with chronic coronary syndrome (CCS). A significantly lower level of 25(OH)D was demonstrated in patients who had another MI compared to those with CCS (p < 0.05). No significant correlation of 25(OH)D concentrations with platelet activity parameters values was found. The subgroup of patients with consecutive MI was characterized by significantly lower serum vitamin D levels, but this was not related to the analyzed parameters of platelet activity.

Neutrophil-to-Lymphocyte Ratio Is Not Associated with Severity of Coronary Artery Disease and Is Not Correlated with Vitamin D Level in Patients with a History of an Acute Coronary Syndrome

“…Statistically significant disproportions between the subgroups of patients were noticed in terms of sex, diabetes, hyperlipidemia, and smoking. Details on factors influencing the cause of hospitalization were presented elsewhere [ 37 ].…”

“…This study analyzed NLR and serum vitamin D concentration in a group of patients with a history of MI as part of a research project aiming to describe the relationship between vitamin D level and CAD severity. In previous studies, we showed significantly decreased serum vitamin D concentration in patients hospitalized for ACS compared to those diagnosed with stable CAD [ 38 ] and no significant differences in platelet activity between these two groups of patients [ 37 ]. Vitamin D concentration did not correlate with MPV and P-LCR [ 37 ].…”

“…In previous studies, we showed significantly decreased serum vitamin D concentration in patients hospitalized for ACS compared to those diagnosed with stable CAD [ 38 ] and no significant differences in platelet activity between these two groups of patients [ 37 ]. Vitamin D concentration did not correlate with MPV and P-LCR [ 37 ]. Results presented in this study suggest that patients with consecutive MI have significantly elevated NLR compared to a group of patients diagnosed with stable CAD.…”

“…The final statistical analysis included 181 men and 87 women, whose ages ranged from 36 to 93 years, with a history of a previous myocardial infarction treated with acetylsalicylic acid and atorvastatin or rosuvastatin. Details on clinical characteristics of the patients were presented in our previous articles [ 37 , 38 , 39 , 40 , 41 , 42 ], as this study is a part of an ongoing project addressing the vitamin D association with the severity of CAD in Polish patients. Exclusion criteria included platelet count <100 or >450 × 10 3 µL, active neoplastic processes or paraneoplastic syndromes, elevated concentrations of inflammatory markers—C-reactive protein concentration >5 mg/L or total white blood count exceeding 10 × 10 3 cells/µL, chronic kidney disease (stages III–V), calcium and phosphorus metabolism disorders as well as vitamin D ingesting as a diet supplement or a medication.…”

“…Details on the study group are presented in Table 1. Table 2, published also in [37], presents a comparison between patients with stable CAD and ACS in measured parameters. ACS and stable CAD were the cause of hospitalization in 60% and 40% of patients, respectively.…”